Abstract: Disclosed are dendrimers of formula (I): and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising the dendrimer of formula (I) and methods of using the same for treating cancer.

Abstract: A method for distributed allocation of data paths in an optical network (100) including optical switches (30, 32, 130) connected by optical links (44, 140), includes receiving a request for a data path for connecting a source node (10) and a destination node (20). In in response to the request, one or more queries are sent, the queries corresponding to one or more candidate optical circuits that connect the source node and the destination node, the queries requesting one or more processors (230) to configure the optical switches along the candidate optical circuits to reserve optical channels on the optical links of the candidate optical circuits for the requested data path. An optical circuit is identified from among the candidate optical circuits, in which all the optical channels for the requested data path have been reserved successfully. The requested data path is established over the identified optical circuit.

Abstract: Disclosed are dendrimers of formula (I): and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising the dendrimer of formula (I) and methods of using the same for treating cancer.

Abstract: Disclosed are dendrimers of formula (I): and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising the dendrimer of formula (I) and methods of using the same for treating cancer.

Abstract: Disclosed are dendrimers of formula (I): and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising the dendrimer of formula (I) and methods of using the same for treating cancer.

Abstract: The present invention generally relates to macromolecules of dendrimer-drug conjugates. In particular, the invention relates to macromolecules comprising a pharmaceutically active agent, such as a protein or peptide, attached to a core of a dendrimer derived from branched building units, such as lysine or lysine analogues. The invention also relates to the synthesis of the dendrimers and macromolecules, and the use of such macromolecules, particularly in therapeutic applications, and pharmaceutical compositions comprising them.

Abstract: Disclosed are dendrimers of formula (I): and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising the dendrimer of formula (I) and methods of using the same for treating cancer.

Abstract: Disclosed are dendrimers of formula (I): and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising the dendrimer of formula (I) and methods of using the same for treating cancer.

Abstract: Disclosed are dendrimers of formula (I): and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising the dendrimer of formula (I) and methods of using the same for treating cancer.

Abstract: The present invention generally relates to macromolecules of dendrimer-drug conjugates. In particular, the invention relates to macromolecules comprising a pharmaceutically active agent, such as a protein or peptide, attached to a core of a dendrimer derived from branched building units, such as lysine or lysine analogues. The invention also relates to the synthesis of the dendrimers and macromolecules, and the use of such macromolecules, particularly in therapeutic applications, and pharmaceutical compositions comprising them.

Abstract: A jewelry item includes a chain, which has decorative items attached to it and which has a first fastening device to hang the item from an object such as a belt loop. A second fastening device is used to adjust the length of the object. Decorative items may be attached to the chain for providing an aesthetically pleasing appearance and for gathering together into a conglomeration to conceal the chain and providing a singular compact appearance for the jewelry item. A swivel coupled to the first fastening device permits the jewelry item to be rotated to an alternate viewing position.