Patents by Inventor Michael Gottfried

Michael Gottfried has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of 4-(4-amino-3-fluorophenoxy)-N-methylpyyridine-2-carboxamide
    Patent number: 10822305
    Abstract: The present invention relates to a process for preparing 4-{4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide, its salts and monohydrate.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: November 3, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Juergen Stiehl, Werner Heilmann, Michael Lögers, Joachim Rehse, Michael Gottfried, Saskia Wichmann
  • Process for the Preparation of 4-(4-amino-3-fluorophenoxy)-N-methylpyyridine-2-carboxamide
    Publication number: 20190144391
    Abstract: The present invention relates to a process for preparing 4-(4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide, its salts and monohydrate.
    Type: Application
    Filed: January 9, 2019
    Publication date: May 16, 2019
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Juergen STIEHL, Werner HEILMANN, Michael LÖGERS, Joachim REHSE, Michael GOTTFRIED, Saskia WICHMANN
  • Method for the phosgenation of compounds comprising hydroxyl, thiol, amino and/or formamide groups
    Patent number: 10118145
    Abstract: A method of reacting phosgene with a second compound containing one or more of hydroxyl, thil, amino and/or formamide groups, wherein phosgene has a GHS hazard identification of GHS06 and is obtainable from the reaction of carbon monoxide and chlorine and wherein the second compound is capable of a chemical reaction with phosgene is provided.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: November 6, 2018
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Jens Stefan Roggan, Leslaw Mleczko, Konstantinos Metaxas, Michael Gottfried, Ilja Peckermann, Stephan Schubert, Ekkehard Barth
  • Method of Purifying and using 4-chloro-n-methy1-2-pyridinecarboxamide
    Publication number: 20170334857
    Abstract: The present invention relates to a process for preparing 4-(4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy)-N-methylpyridine-2-carboxamide, its salts and monohydrate.
    Type: Application
    Filed: August 3, 2017
    Publication date: November 23, 2017
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Juergen STIEHL, Werner HEILMANN, Michael LOGERS, Joachim REHSE, Michael GOTTFRIED, Saskia WICHMANN
  • METHOD FOR THE PHOSGENATION OF COMPOUNDS COMPRISING HYDROXYL, THIOL, AMINO AND/OR FORMAMIDE GROUPS
    Publication number: 20170274341
    Abstract: A method of reacting a first compound with a second compound, wherein the first compound has a GHS hazard identification of GHS06 and is obtainable from the reaction of at least one first fluid precursor compound and one second fluid precursor compound and wherein the second compound is capable of a chemical reaction with the first compound is provided
    Type: Application
    Filed: August 18, 2015
    Publication date: September 28, 2017
    Inventors: JENS STEFAN ROGGAN, LESLAW MLECZKO, KONSTANTINOS METAXAS, MICHAEL GOTTFRIED, IIJA PECKERMANN, STEPHAN SCHUBERT, EKKEHARD BARTH
  • PROCESS FOR THE PREPARATION OF 4-CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-ETHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE
    Publication number: 20170057918
    Abstract: The present invention relates to a process for preparing 4-{4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide, its salts and monohydrate.
    Type: Application
    Filed: September 8, 2016
    Publication date: March 2, 2017
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Juergen STIEHL, Werner HEILMANN, Michael LÖGERS, Joachim REHSE, Michael GOTTFRIED, Saskia WICHMANN
  • Process for the preparation of 4-{4-[({[4 chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorphenoxy--ethylpyridie-carboxamide, its salts and monohydrate
    Patent number: 9458107
    Abstract: The present invention relates to a process for preparing 4-(4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy)-N-methylpyridine-2-carboxamide, its salts and monohydrate.
    Type: Grant
    Filed: April 15, 2014
    Date of Patent: October 4, 2016
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Juergen Stiehl, Werner Heilmann, Michael Lögers, Joachim Rehse, Michael Gottfried, Saskia Wichmann
  • PROCESS FOR THE PREPARATION OF 4-CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-ETHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE
    Publication number: 20140221661
    Abstract: The present invention relates to a process for preparing 4-(4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy)-N-methylpyridine-2-carboxamide, its salts and monohydrate.
    Type: Application
    Filed: April 15, 2014
    Publication date: August 7, 2014
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Juergen STIEHL, Werner HEILMANN, Michael L.GERS, Joachim REHSE, Michael GOTTFRIED, Saskia WICHMANN
  • Process for the preparation of 4-{4[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy}--methylpyridine-2-carboxamide, its salts and monohydrate
    Patent number: 8748622
    Abstract: The present invention relates to a process for preparing 4-{4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide, its salts and monohydrate.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: June 10, 2014
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Juergen Stiehl, Werner Heilmann, Michael Lögers, Joachim Rehse, Michael Gottfried, Saskia Wichmann
  • PROCESS FOR THE PREPARATION OF 4-CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE
    Publication number: 20130116442
    Abstract: The present invention relates to a process for preparing 4-{4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide, its salts and monohydrate.
    Type: Application
    Filed: April 8, 2011
    Publication date: May 9, 2013
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Juergen Stiehl, Werner Heilmann, Michael Lögers, Joachim Rehse, Michael Gottfried, Saskia Wichmann
  • N-(2-aminophenyl)-4-[N-(pyridine-3-yl)-methoxycarbonyl-aminomethyl]-benzamide (MS-275) polymorph B
    Patent number: 7973166
    Abstract: The crystalline Polymorph B of N-(2-aminophenyl)-4-[N-(pyridine-3-yl)methoxy-carbonyaminomethyl]benzamide (MS-275) of formula I is described, as well as the process for the production of said compound, and its use as a medicament for the treatment of selected diseases.
    Type: Grant
    Filed: August 28, 2009
    Date of Patent: July 5, 2011
    Assignee: Bayer Schering Pharma AG
    Inventors: Matthias Schneider, Michael Gottfried, Jens Geisler, Gabriele Winter
  • N-(2-Aminophenyl)-4-[N-(Pyridine-3-yl)-Methoxycarbonyl-Aminomethyl]-Benzamide (MS-275) Polymorph B
    Publication number: 20100056585
    Abstract: The crystalline Polymorph B of N-(2-aminophenyl)-4-[N-(pyridine-3-yl)methoxy-carbonyaminomethyl]benzamide (MS-275) of formula I is described, as well as the process for the production of said compound, and its use as a medicament for the treatment of selected diseases.
    Type: Application
    Filed: August 28, 2009
    Publication date: March 4, 2010
    Applicant: BAYER SCHERING PHARMA AG
    Inventors: Matthias Schneider, Michael Gottfried, Jens Geisler, Gabriele Winter
  • Process for the production of high-purity rac-1-{4-[2-hydroxy-3-(5-quinolyloxy)propyl]-piperazin-1-yl}-2,2-diphenylethan-1-one fumarate and high-purity rac-1-{4-[2-hydroxy-3-(5-quinolyloxy)propyl]piperazin-1-yl}-2,2-diphenylethan-1-one fumarate
    Patent number: 7462718
    Abstract: A process for the production of high-purity rac-1-{4-[2-hydroxy-3-(5-quinolyloxy)propyl]-piperazin-1-yl}-2,2-diphenylethan-1-one fumarate as well as rac-1-{4-[2-hydroxy-3-(5-quinolyloxy)propyl]piperazin-1-yl}-2,2-diphenylethan-1-one fumarate at a purity of at least 98.55% is described.
    Type: Grant
    Filed: May 6, 2004
    Date of Patent: December 9, 2008
    Assignee: Schering AG
    Inventors: Hilmar Weinmann, Matthias Schneider, Michael Gottfried
  • Process for the production of high-purity rac-1-{4-[2-hydroxy-3-(5-quinolyloxy)propyl]-piperazin-1-yl}-2,2-diphenylethan-1-one fumarate and high-purity rac-1-{4-[2-hydroxy-3-(5-quinolyloxy)propyl]piperazin-1-yl}-2,2-diphenylethan-1-one fumarate
    Publication number: 20050014945
    Abstract: A process for the production of high-purity rac-1-{4-[2-hydroxy-3-(5-quinolyloxy)propyl]-piperazin-1-yl}-2,2-diphenylethan-1-one fumarate as well as rac-1-{4-[2-hydroxy-3-(5 -quinolyloxy)propyl]piperazin-1-yl}-2,2-diphenylethan-1-one fumarate at a purity of at least 98.55% is described.
    Type: Application
    Filed: May 6, 2004
    Publication date: January 20, 2005
    Inventors: Hilmar Weinmann, Matthias Schneider, Michael Gottfried
  • Multi-stage method for producing gas-filled microcapsules
    Patent number: 6652782
    Abstract: The invention relates to a multi-stage method for producing gas-filled microcapsules. In one stage of the method, the substance that forms the coat is polymerized. The microcapsules are formed in a physically and/or temporally separate stage, by means of a structuring process. The polymerization is carried out with moderate stirring, while the microcapsules are structured in dispersing conditions.
    Type: Grant
    Filed: March 27, 2002
    Date of Patent: November 25, 2003
    Assignee: Schering Aktiengesellschaft
    Inventors: Uwe Budde, Andreas Briel, Georg Rossling, Kai Lovis, Wolfgang Schmidt, Hans-Ulrich Moritz, Michael Gottfried, Jan-Peter Ingwersen
  • Method of producing amino acids and amino-acid derivatives
    Patent number: 6121487
    Abstract: The present invention is relative to a chemical method of producing compounds of the general formula (I) ##STR1## starting from compounds of the general formula (II) and (III) ##STR2## under radical conditions. Products I are used as intermediates in the synthesis of bioactive substances.
    Type: Grant
    Filed: July 28, 1999
    Date of Patent: September 19, 2000
    Assignee: Degussa-Huls Aktiengesellschaft
    Inventors: Annegret Vogt, Hans-Josef Altenbach, Michael Kirschbaum, Michael-Gottfried Hahn, Mike Siegfried Paul Matthaus, Andreas Rainer Hermann
  • N-(2-aminophenyl)-4-[N-(pyridine-3-yl)-methoxycarbonyl-aminomethyl]-benzamide (MS-275) polymorph B
    Patent number: RE45499
    Abstract: The crystalline Polymorph B of N-(2-aminophenyl)-4-[N-(pyridine-3-yl)methoxy-carbonyaminomethyl]benzamide (MS-275) of formula I is described, as well as the process for the production of said compound, and its use as a medicament for the treatment of selected diseases.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: April 28, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Matthias Schneider, Michael Gottfried, Jens Geisler, Gabriele Winter, Joji Suzuki, Tomoyuki Ando, Masaru Honjo