Patents by Inventor Michael Graeber

Michael Graeber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170216235
    Abstract: A regimen for the safe and effective long-term treatment of acne vulgaris entails topically applying onto the affected skin area of a subject afflicted therewith, for a period of time of at least four (4) months, e.g., for at least twelve (12) months and advantageously on a daily basis and preferably once a day, a thus effective amount of a topical medicament containing adapalene and benzoyl peroxide, formulated into a pharmaceutically acceptable medium therefor.
    Type: Application
    Filed: April 21, 2017
    Publication date: August 3, 2017
    Inventors: Michael GRAEBER, Yin LIU, Barbara GORE
  • Publication number: 20170216231
    Abstract: The present invention concerns a pharmaceutical composition comprising 0.3% by weight of adapalene or a pharmaceutically acceptable salt thereof and 2.5% by weight of benzoyl peroxide, as active ingredients, for its use by topical administration in the treatment of inflammatory acne lesions. The present invention further concerns regimen for the therapeutic treatment of acne lesions in subjects afflicted with severe acne. The regimen includes topically applying to a subject's skin, as active ingredients, 0.3% by weight adapalene and 2.5% by weight benzoyl peroxide, combined in a single formula that delivers the active ingredients together. The single formula can for example be applied once or twice daily for a period of 8 to 12 weeks.
    Type: Application
    Filed: July 16, 2015
    Publication date: August 3, 2017
    Inventors: Matthew James LEONI, Michael GRAEBER, Vasant MANNA
  • Publication number: 20170181991
    Abstract: Dermatological disorders having an inflammatory or proliferative component, notably common acne, are treated with topically applicable pharmaceutical compositions containing about 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid (adapalene) or salt thereof, formulated into pharmaceutically acceptable media therefor, advantageously formulated into topically applicable gels, preferably aqueous gels, creams, lotions or solutions.
    Type: Application
    Filed: March 13, 2017
    Publication date: June 29, 2017
    Inventors: Michael GRAEBER, Janusz CZERNIELEWSKI
  • Patent number: 9622994
    Abstract: Dermatological disorders having an inflammatory or proliferative component, notably common acne, are treated with topically applicable pharmaceutical compositions containing about 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid (adapalene) or salt thereof, formulated into pharmaceutically acceptable media therefor, advantageously formulated into topically applicable gels, preferably aqueous gels, creams, lotions or solutions.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: April 18, 2017
    Assignee: GALDERMA RESEARCH & DEVELOPMENT
    Inventors: Michael Graeber, Janusz Czernielewski
  • Publication number: 20170095434
    Abstract: The present invention concerns a pharmaceutical composition comprising 0.3% by weight of adapalene or a pharmaceutically acceptable salt thereof and 2.5% by weight of benzoyl peroxide, as active ingredients, for its use by topical administration in the treatment of inflammatory acne lesions. The present invention further concerns regimen for the therapeutic treatment of acne lesions in subjects afflicted with severe acne. The regimen includes topically applying to a subject's skin, as active ingredients, 0.3% by weight adapalene and 2.5% by weight benzoyl peroxide, combined in a single formula that delivers the active ingredients together. The single formula can for example be applied once or twice daily for a period of 8 to 12 weeks.
    Type: Application
    Filed: December 19, 2016
    Publication date: April 6, 2017
    Inventors: Matthew James LEONI, Michael GRAEBER, Vasant MANNA
  • Publication number: 20170087085
    Abstract: Methods and products for treating or preventing erythema or a symptom associated with erythema in a subject are described. The methods involve topically applying to an affected skin area a topical aqueous gel composition comprising about 0.01% to about 10% by weight of at least one ?-adrenergic receptor agonist and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: December 8, 2016
    Publication date: March 30, 2017
    Inventors: Michael GRAEBER, Christian LOESCHE, Philip FREIDENREICH, Jack A. DEJOVIN, Isabelle Jean DEJOVIN, Yin-sang LIU, Matthew James LEONI
  • Publication number: 20170049732
    Abstract: Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthanoic acid (adapalene) or salt thereof, formulated into pharmaceutically acceptable media therefor, advantageously topically applicable gels, creams or lotions.
    Type: Application
    Filed: June 16, 2016
    Publication date: February 23, 2017
    Inventors: Michael GRAEBER, Janusz CZERNIELEWSKI
  • Patent number: 9554988
    Abstract: Methods, compositions and products for preventing skin tumor formation or inhibiting the development of an existing skin tumor in a subject are described. The methods involve administering to the subject a composition containing an ? adrenergic receptor agonist, such as brimonidine.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: January 31, 2017
    Assignee: Galderma Research & Development
    Inventors: Guy Bouvier, Matthew James Leoni, Michael Graeber
  • Publication number: 20160361282
    Abstract: Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthanoic acid (adapalene) or salt thereof, formulated into pharmaceutically acceptable media therefor, advantageously topically applicable gels, creams or lotions.
    Type: Application
    Filed: June 7, 2016
    Publication date: December 15, 2016
    Inventors: Michael GRAEBER, Janusz CZERNIELEWSKI
  • Patent number: 9387187
    Abstract: Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthanoic acid (adapalene) or salt thereof, formulated into pharmaceutically acceptable media therefor, advantageously topically applicable gels, creams or lotions.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: July 12, 2016
    Assignee: GALDERMA RESEARCH & DEVELOPMENT
    Inventors: Michael Graeber, Janusz Czernielewski
  • Patent number: 9381179
    Abstract: Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthanoic acid (adapalene) or salt thereof, formulated into pharmaceutically acceptable media therefor, advantageously topically applicable gels, creams or lotions.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: July 5, 2016
    Assignee: GALDERMA RESEARCH & DEVELOPMENT
    Inventors: Michael Graeber, Janusz Czernielewski
  • Publication number: 20160184342
    Abstract: Methods for safe and effective treatment of inflammatory lesions of rosacea in a subject are described. The methods involve once daily topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. It has been demonstrated that once daily topical treatment with ivermectin is significantly superior than twice-daily topical treatment with metronidazole in reducing inflammatory lesion counts.
    Type: Application
    Filed: July 8, 2014
    Publication date: June 30, 2016
    Inventors: Jean JACOVELLA, Jean-Paul CHAPPUIS, Nathalie SORDELLO WAGNER, Alexandre KAOUKHOV, Michael GRAEBER, Laurence SALIN, Michel PONCET, Philippe BRIANTAIS, Khaled BENKALI
  • Publication number: 20160175337
    Abstract: Methods and compositions for safe and effective treatment of papulopustular rosacea in a subject are described. The methods involve topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. Treatment with ivermectin represents an innovative therapy that is more robust and effective than the conventional treatments.
    Type: Application
    Filed: December 17, 2015
    Publication date: June 23, 2016
    Inventors: Jean JACOVELLA, Jean-Paul CHAPPUIS, Alexandre KAOUKHOV, Michael GRAEBER, Michel PONCET, Philippe BRIANTAIS, Laurence SALIN
  • Publication number: 20160158263
    Abstract: Methods and compositions for safe and effective treatment of papulopustular rosacea in a subject are described. The methods involve topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. Treatment with ivermectin represents an innovative therapy that is more robust and effective than the conventional treatments.
    Type: Application
    Filed: July 8, 2014
    Publication date: June 9, 2016
    Inventors: Jean JACOVELLA, Jian-Paul CHAPPUIS, Alexandre KAOUKHOV, Michael GRAEBER, Laurence SALIN, Michel PONCET, Philippe BRIANTAIS
  • Publication number: 20160143935
    Abstract: Methods for safe and effective treatment of inflammatory lesions of rosacea in a subject are described. The methods involve once daily topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. It has been demonstrated that once daily topical treatment with ivermectin is significantly superior than twice-daily topical treatment with metronidazole in reducing inflammatory lesion counts.
    Type: Application
    Filed: December 17, 2015
    Publication date: May 26, 2016
    Inventors: Jean JACOVELLA, Jean-Paul CHAPPUIS, Nathalie SORDELLO WAGNER, Michael GRAEBER, Alexandre KAOUKHOV, Laurence SALIN, Michel PONCET, Philippe BRIANTAIS, Khaled BENKALI
  • Publication number: 20160095857
    Abstract: Improved methods and compositions for safe and effective treatment of erythema or a symptom associated with erythema in a subject are described. The methods involve topically applying to an affected skin area a topical composition comprising about 0.3% to about 10% by weight of brimonidine and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: December 14, 2015
    Publication date: April 7, 2016
    Inventors: Michael GRAEBER, Christian LOESCHE, Philip FREIDENREICH, Yin-sang LIU, Matthew James LEONI
  • Publication number: 20160008355
    Abstract: Methods and products for treating or preventing erythema or a symptom associated with erythema in a subject are described. The methods involve topically applying to an affected skin area a topical aqueous gel composition comprising about 0.01% to about 10% by weight of at least one ?-adrenergic receptor agonist and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: September 23, 2015
    Publication date: January 14, 2016
    Inventors: Michael GRAEBER, Christian LOESCHE, Philip FREIDENREICH, Jack A. DEJOVIN, Isabelle Jean DEJOVIN, Yin-sang LIU, Matthew James LEONI
  • Patent number: 9233118
    Abstract: Methods and compositions for safe and effective treatment of papulopustular rosacea in a subject are described. The methods involve topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. Treatment with ivermectin represents an innovative therapy that is more robust and effective than the conventional treatments.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: January 12, 2016
    Assignee: Galderma S.A.
    Inventors: Jean Jacovella, Jean-Paul Chappuis, Alexandre Kaoukhov, Michael Graeber, Michel Poncet, Philippe Briantais, Laurence Salin
  • Patent number: 9233117
    Abstract: Methods for safe and effective treatment of inflammatory lesions of rosacea in a subject are described. The methods involve once daily topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. It has been demonstrated that once daily topical treatment with ivermectin is significantly superior than twice-daily topical treatment with metronidazole in reducing inflammatory lesion counts.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: January 12, 2016
    Assignee: Galderma S. A.
    Inventors: Jean Jacovella, Jean-Paul Chappuis, Nathalie Sordello Wagner, Michael Graeber, Alexandre Kaoukhov, Laurence Salin, Michel Poncet, Philippe Briantais, Khaled Benkali
  • Patent number: D758048
    Type: Grant
    Filed: December 31, 2014
    Date of Patent: June 7, 2016
    Assignee: Gladerma Research & Development SNC
    Inventors: Paul Martinetti, Bernadette Irene Mangione, Jerry Kim Leng Tan, Shannon Louise Moore, Diane Travaglini Rudisill, Valerie Tillier-LeFrancois, Matthew James Leoni, Michael Graeber, Alessandra Beatriz Alio-Saenz, Marie Helene Peirone, Jae Karlo Calandria Lopez, Joyce Lee Hwa