Abstract: The Network For Multi-Media Management enables a reverse path feedback architecture wherein the forward path multicasted content can be dynamically modified as a result of end user interaction or feedback. End users in the Network For Multi-Media Management are grouped via location or region, together with personal attributes such as demographic, socio-graphic, or psychographic interests as it relates to a given multicasted content stream. The pairing of physical location groupings with personal interest attributes enables new and novel telecommunication services with the attendant advantage of extremely efficient delivery. The wireless communication network's capacity utilization, both in terms of assets and spectrum, is very high.

Abstract: The reverse path transaction management system enables the subscriber to receive a multicast on their wireless subscriber device via the forward path of a multicast channel or via a unidirectional broadcast channel concurrently with a plurality of other subscribers on the same multicast channel or broadcast channel. The subscribers can simultaneously initiate a transaction to purchase goods and/or services via the reverse path associated with the shared multicast channel or via a separate cellular communication connection associated with the broadcast channel. Typically, goods and/or services are offered to the subscriber as part of the multicast extant on the shared forward channel.

Abstract: The Forward Path Multi-Media Management System architecture enables end user devices to share a common wireless forward path of a multicast communication architecture in which the forward path delivered content is dynamically changed or modified based on a real-time, near-real-time, or delay-time basis via aggregated reverse path feedback from at least one of a plurality of end user devices. The Forward Path Multi-Media Management System periodically or continuously aggregates the feedback input received via the reverse path (having wired and/or wireless connectivity), modifies the forward path multi-media content, and delivers this dynamically modified multi-media content to the then connected population of end user devices via a wireless forward path multicast in a repetitive closed loop fashion.

Abstract: TruCast is a method for management, by way of gathering, storing, analyzing, tracking, sorting, determining the relevance of, visualizing, and responding to all available consumer generated media. Some examples of consumer generated media include web logs or “blogs”, mobile phone blogs or “mo-blogs”, forums, electronic discussion messages, Usenet, message boards, BBS emulating services, product review and discussion web sites, online retail sites that support customer comments, social networks, media repositories, and digital libraries. Any web hosted system for the persistent public storage of human commentary is a potential target for this method. The system is comprised of a coordinated software and hardware system designed to perform management, collection, storage, analysis, workflow, visualization, and response tasks upon this media.

Abstract: TruCast is a method for management, by way of gathering, storing, analyzing, tracking, sorting, determining the relevance of, visualizing, and responding to all available consumer generated media. Some examples of consumer generated media include web logs or “blogs”, mobile phone blogs or “mo-blogs”, forums, electronic discussion messages, Usenet, message boards, BBS emulating services, product review and discussion web sites, online retail sites that support customer comments, social networks, media repositories, and digital libraries. Any web hosted system for the persistent public storage of human commentary is a potential target for this method. The system is comprised of a coordinated software and hardware system designed to perform management, collection, storage, analysis, workflow, visualization, and response tasks upon this media.

Abstract: The present self-configuring alarm network uses a decentralized (ad hoc or mesh) architecture that does not have a centralized “master” node. In this ad hoc network, any node is capable of behaving as if it were the “master node” by autonomously reporting the alarm event directly to all other nodes in the ad hoc network independent of where the alarm event occurred. The network of alarm devices, therefore, can spread the alarm indication to the entirety of the area covered by the network of alarm devices and can also differentiate between a general alarm indication and the locus of the alarm event.

Abstract: The present self-configuring emergency event alarm network uses a decentralized (ad hoc or mesh) architecture that does not have a centralized “master” node. In this ad hoc network, any node is capable of behaving as if it were the “master node” by autonomously reporting the alarm event directly to all other nodes in the ad hoc network independent of where the alarm event occurred. The network of alarm devices, therefore, can spread the alarm indication to the entirety of the area covered by the network of alarm devices and can also differentiate between a general alarm indication and the locus of the alarm event.

Abstract: A crystalline polymorph of a bislulfate salt of a thrombin receptor antagonist compound, which exhibits a powder x-ray diffraction profile substantially the same as that shown in FIG. 1, or which exhibits a differential scanning calorimtery profile substantially the same as that shown in FIG. 3, and is represented by the formula for Compound 2: and processes for preparing Compound 2 are disclosed. Pharmaceutical compositions comprising the polymorph of the bisulfate salt and at least one excipient or carrier, and methods of using the polymorph of Compound 2 to treat a variety of physiological disorders, such as thrombosis, are also disclosed.

Abstract: The present invention relates to pharmaceutical compositions comprising therapeutic combinations comprising: one or more H3 antagonists/inverse agonists; one or more appetite suppressants selected from the group consisting of CB1 antagonists/inverse agonists, sibutramine, phentermine and topiramate; and optionally one or more HMG-CoA reductase inhibitors. The invention also relates to medicaments and kits comprising the pharmaceutical compositions of the present invention, and methods of treating obesity, obesity related disorders and diabetes using the pharmaceutical compositions of the present invention.

Abstract: The use of azetidinone compounds that are inhibitors of cholesterol absorption as tools for discovering and characterizing proteins involved in trafficking or absorption of cholesterol and/or cholesteryl esters in biological systems is presented These compounds can serve as tools for competitive binding assays to discover and characterize other chemical agents useful as cholesterol absorption inhibitors. New compounds of the present invention are also highly efficacious inhibitors of cholesterol absorption.

Abstract: The present invention provides human, rat and mouse NPC1L1 polypeptides and polynucleotides encoding the polypeptides. Also provided are methods for detecting agonists and antagonists of NPC1L1. Inhibitors of NPC1L1 can be used for inhibiting intestinal cholesterol absorption in a subject.

Abstract: A compound represented by the structural formula and pharmaceutically acceptable salts and solvents thereof is disclosed, wherein: the single-dashed line between the ring carbons to which R10 and R34 are attached represents either a single bond or a double bond; the double-dashed line between X and the carbon to which Y is attached represents either a single bond or an absent bond; X is —O— or —NR6— when the double-dashed line represents a single bond; X is H, —OH or —NHR20 when the double-dashed line represents an absent bond; and other parameters are as defined herein. Also disclosed are pharmaceutical compositions and combinations containing said compounds and their uses as thrombin receptor antagonists and binders to cannabinoid receptors.

Abstract: The use of azetidinone compounds that are inhibitors of cholesterol absorption as tools for discovering and characterizing proteins involved in trafficking or absorption of cholesterol and/or cholesteryl esters in biological systems is presented. These compounds can serve as tools for competitive binding assays to discover and characterize other chemical agents useful as cholesterol absorption inhibitors. New compounds of the present invention are also highly efficacious inhibitors of cholesterol absorption.

Abstract: The present invention provides compositions, therapeutic combinations and methods including: (a) at least one lipid modulating agent; and (b) at least one substituted azetidinone or substituted ?-lactam sterol absorption inhibitor which can be useful for treating vascular conditions, diabetes, obesity and lowering plasma levels of sterols or 5?-stanols.

Abstract: An assembly for automatic background color change of a monochrome liquid crystal display comprising a monochrome liquid display, a dichroic guest-host cell, and a backlight device, emitting light in visible region of the spectrum. The devices are arranged in a sequence of, from top to bottom, liquid crystal display, dichroic cell and backlight device. The dichroic cell comprising a single dye or combination of dye, together with liquid crystal molecules, absorbing characteristic wavelengths from the spectrum of the backlight device and transmitting the remaining wavelengths, on application of suitable voltage to the cell. The assembly is integrated to form a single unit in which the three devices namely, liquid crystal display, dichroic cell and white light emitting backlight share at least one substrate with each other. On application of different amplitude of voltage to the dichroic cell, hues of colors as background colors for monochrome liquid crystal display is generated.

Abstract: A method and system for verifying the intended imaging produced by a printer allow this task to be accomplished in essentially real-time, and utilizing relatively inexpensive, and high speed (e.g. about 200 feet per minute or greater) components. A computer control commands a raster image processor (RIP) to generate electronic print data (e.g. a bitmap) that is sent to an electronic digital printer (such as an inkjet cartridge array) and also to a print monitor. The printer images the bitmap onto a web or sheet, then a linear digital photosensor (e.g. photodiode) array scans essentially every pixel across the width of the web or sheet image area and transmits the scanned data to the print monitor system, which compares it to the bitmap produced by the RIP.

Abstract: A fluid (liquid or water) wash is used to clean the front surface of an ink jet printer cartridge. In addition, a nozzle plate that overlies the nozzle shields the nozzle array from the splatter of ink. In ink jet printers, ink droplets are propelled from an array of orifices in a nozzle plate in the printer head. During the ink droplet ejection, ink is sprayed or deposited around the orifices. The ink droplets are deposited on a paper web adjacent the nozzle and mist from the droplets drifts back to coat the face of the nozzle plate. Some ink seeps behind the nozzle plate onto the array of nozzle orifices. The ink coating attracts particles that tend to clog the nozzle orifices. The ink coating is washed away by fluid streams that flow over the nozzle surface and in some embodiments flow over the nozzle orifices themselves. The fluid may be water, ink or other liquid that is channelled across the nozzle surface, or the fluid may be an air stream that blows across the nozzle surface.

Abstract: Substantially optimum print quality is maintained for an ink jet printer which includes a nozzle plate having a number of orifice openings from which ink droplets for printing are sprayed. It is electronically determined when a particular orifice opening has been inactive for a predetermined period of time, and then an exercise print command is supplied to the orifice causing an ink droplet to dribble out of the orifice, rather than being sprayed out of the orifice, to keep the orifice clear for printing when a print command is supplied to it. The dribbling drops have a smaller size than the sprayed drops, and may be formed by supplying heater elements associated with the openings with pulses of shorter duration than normal. Dribbling ink droplets are automatically removed from the printer cartridge by one or more strands (e.g. continuous filament rayon thread) moving past the nozzle at a speed of between about 1-3 feet per hour while being positively guided.

Abstract: In a printer assembly having a rack of ink-jet print cartridges, a backup cartridge is moved into alignment with a cartridge to be cleaned and the backup cartridge substitutes for printing of the cartridge being cleaned until the cleaned cartridge is moved back to its printing position. The backup cartridge is then moved into alignment with another cartridge and prints for that cartridge which is then cleaned. Ink-jet print cartridges must be periodically cleaned to wipe excess ink and particles from the nozzle array on the front face of the cartridge. Cartridges are cleaned by moving them to a cleaning station that wipes clean the front face of the cartridge. To avoid interruption of printing while cartridges are being cleaned, a backup cartridge is moved into alignment and substitute prints for a cartridge to be cleaned.