Abstract: The invention provides a respiratory mask comprising a mask body including a base and walls upstanding from the base and converging towards an apical region and a forehead engagement member extending from the apical region of the mask body. The forehead engagement member coupled to the mask body so as to be movable relative to the mask body in a sagittal plane when the mask body is worn by a patient. An adjustment mechanism is provided for adjusting the relative positions of the forehead engagement member and the mask body. In another aspect, the invention also provides a respiratory mask including a mask body including a base and walls upstanding from the base and converging towards an apical region. The body includes a pair of transversely opposite headgear anchors adapted for attachment to headgear that a patient wears during use to secure the mask to the face of a patient.

Abstract: The invention provides a respiratory mask comprising a mask body including a base and walls upstanding from the base and converging towards an apical region and a forehead engagement member extending from the apical region of the mask body. The forehead engagement member coupled to the mask body so as to be movable relative to the mask body in a sagittal plane when the mask body is worn by a patient. An adjustment mechanism is provided for adjusting the relative positions of the forehead engagement member and the mask body. In another aspect, the invention also provides a respiratory mask including a mask body including a base and walls upstanding from the base and converging towards an apical region. The body includes a pair of transversely opposite headgear anchors adapted for attachment to headgear that a patient wears during use to secure the mask to the face of a patient.

Abstract: The invention provides methods and compositions for use in the diagnosis and management of cancer, particularly breast cancer. The invention utilizes differential gene expression profiles in tumor associated stroma and normal stroma to compile a stroma derived prognostic predictor that classifies breast cancer patients according to clinical outcome. The application provides nucleic acids, antibodies, microarray chips and kits for use with the methods described in the application.

Abstract: The invention prevents dynamic airway compression during ventilatory support of a patient. The respiratory airflow is determined by measurement or calculation, and a measure of the degree of dynamic airway compression is derived from the determined airflow. This measure is servo-controlled to be zero by increasing expiratory pressure if the measure of the degree of dynamic airway compression is large or increasing, and by reducing expiratory pressure if the measure of the degree of dynamic airway compression is small or zero.

Abstract: The invention prevents dynamic airway compression during ventilatory support of a patient. The respiratory airflow is determined by measurement or calculation, and a measure of the degree of dynamic airway compression is derived from the determined airflow. This measure is servo-controlled to be zero by increasing expiratory pressure if the measure of the degree of dynamic airway compression is large or increasing, and by reducing expiratory pressure if the measure of the degree of dynamic airway compression is small or zero.