Abstract: The present invention relates to a polypeptide binding to a chymase (EC 3.4.21.

Abstract: The present invention relates to a polypeptide binding to a chymase (EC 3, 4, 21,39), wherein the polypeptide comprises or consists of an amino acid sequence selected from the group consisting of: (a) GVTLFVALYDY(X1)A(X2)(X3)(X4)(X5) (X6)LSFHKGEKFQIL(X7 (X8)(X9)(X10) (X11)(X12)G(X13)(X14)WEARSLTTGETGYIPSNYVAPVDSIQ (SEQ ID NO: 1), wherein (X1) is R, N, Q, E, K, H, S, T, C, or D; (X2) is E, T, D, Q, L, P, A, S, C, M, N, E, G, A, V or I; (X3) is R, T, H, N, K, S, C, N or Q; (X4) is S, W, T, C, N, Q, For Y; (X5) is T, H, L, F, C, S, M, N, Q, R, K, G, A, V, I, P, Y or W; (X6) is D, Q, H, E, S, T, C, N, R or K; (X7) is D, N, R, E, Q, S, T, C, K or D; (X8) is M, W, G, F, A, S, T, C, S, N, Q, Y, V, L, I or P; (X9) is T, H, S, D, C, N, Q, R, K, E or absent; (X10) is V, T, Q, G, A, L, I, P, S, C, M, N or absent; (X11) is P, A, D, G, K, V, L, I, E, R, M, H or absent; (X12) is N, V, P, I, E, T, S, A, G, L, C, M, Q or D; (X13) is D, E, T, P, G, A, V, L, I, S, C, M, N or Q, and (X14) is W, Y, L, G, A, V, I, P, M, or F; (b)

Abstract: A method for producing thermally tempered glass. This type of surface treatment is applied in particular where mechanical properties, in particular strengths, are required, for example in the automotive industry, in architecture and in the utilisation of solar energy. The method produces thermally tempered glass with thicknesses less than 2.8 mm. The method can be advantageously performed such that thermally tempered glass can be produced with less energy input by utilising controlled quenching.

Abstract: Methods for transmission mode X-ray diffraction analysis of a sample by means of apparatuses comprising an X-ray radiation source that provides X-ray radiation for irradiating the sample and a detector for detecting X-ray radiation transmitted through and diffracted by the sample. The methods include: (a) placing a sample to be analyzed on a substrate, (b) generating X-ray radiation by means of an X-ray radiation source, (c) positioning the substrate and the sample in an initial position, (d) rotating the substrate and the sample with respect to the initial position around a rotation axis over a predetermined rotation angle, (e) tilting the substrate and the sample with respect to the initial position around a tilting axis over a tilting angle, (f) detecting with a detector the X-ray radiation transmitted through and diffracted by the sample during a time interval, and (g) analyzing the X-ray radiation that is detected.

Abstract: The present invention provides a crystal of the extracellular domain of mammalian DPP-IV, wherein the crystal has an orthorhombic space group of P212121 and one homodimer of DPP-IV in the asymmetric unit. Also provided is a co-crystal which includes a ligand bound to the active site of mammalian DPP-IV. The invention permits the identification or design of inhibitor compounds of DPP-IV activity, for use in treatment of type II diabetes.

Abstract: The present invention provides crystals of carnitine palmitoyltransferase (CPT) and co-crystals of CPT with an inhibitor compounds that allow screening for novel inhibitors of CPT-2 by determining the structure of co-crystals based on the coordinates of the crystals disclosed herein.

Abstract: The present invention provides a crystal of the extracellular domain of mammalian DPP-IV, wherein the crystal has an orthorhombic space group of P212121 and one homodimer of DPP-IV in the asymmetric unit. Also provided is a co-crystal which includes a ligand bound to the active site of mammalian DPP-IV. The invention permits the identification or design of inhibitor compounds of DPP-IV activity, for use in treatment of type II diabetes.

Abstract: The invention is concerned with a novel polymorph of [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride. This polymorph exhibits superior properties compared to the previously known forms of [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride. The [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride is an inhibitor of tyrosine kinase enzymes, and are useful in the treatment of cancer. Also disclosed are methods of making and using the novel polymorph, as well as pharmaceutical compositions containing the novel polymorph.

Abstract: Methods for transmission mode X-ray diffraction analysis of a sample by means of apparatuses comprising an X-ray radiation source that provides X-ray radiation for irradiating the sample and a detector for detecting X-ray radiation transmitted through and diffracted by the sample. The methods include: (a) placing a sample to be analyzed on a substrate, (b) generating X-ray radiation by means of an X-ray radiation source, (c) positioning the substrate and the sample in an initial position, (d) rotating the substrate and the sample with respect to the initial position around a rotation axis over a predetermined rotation angle, (e) tilting the substrate and the sample with respect to the initial position around a tilting axis over a tilting angle, (f) detecting with a detector the X-ray radiation transmitted through and diffracted by the sample during a time interval, and (g) analyzing the X-ray radiation that is detected.

Abstract: The present invention is concerned with pseudopolymorphic forms of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole (carvedilol) or of optically active forms or pharmaceutically acceptable salts thereof, processes for the preparation thereof and pharmaceutical compositions containing them.

Abstract: This invention relates to a coextruded biaxially stretched tubular film for the durable and crease-free covering of goods packaged in the liquid or pasty state, in particular foodstuffs such as sausage-meat for boiling or cooking or soft cheese, which are heated during and/or after they are packaged.

Abstract: The present invention is concerned with pseudopolymorphic forms of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole (carvedilol) or of optically active forms or pharmaceutically acceptable salts thereof, processes for the preparation thereof and pharmaceutical compositions containing them.

Abstract: The invention is concerned with a novel polymorph of [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride. This polymorph exhibits superior properties compared to the previously known forms of [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride. The [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride is an inhibitor of tyrosine kinase enzymes, and are useful in the treatment of cancer. Also disclosed are methods of making and using the novel polymorph, as well as pharmaceutical compositions containing the novel polymorph.

Abstract: The present invention is concerned with pseudopolymorphic forms of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole (carvedilol) or of optically active forms or pharmaceutically acceptable salts thereof, processes for the preparation thereof and pharmaceutical compositions containing them.

Abstract: The invention relates to a multi-layer, coextruded, biaxially oriented tubular sausage casing with improved oxygen barrier properties especially for wrapping sausages, which are heat treated after filling.

Abstract: The invention relates to a coextruded, biaxially stretched, tubular film, with at least two adjacent layers made from aliphatic polyamide, for wrapping goods packaged in liquid or paste form, especially foodstuffs, which are subjected to heat-treatment during and/or after being wrapped, such as for example, various types of German sausage, cheese, butter, etc.

Abstract: An at least 4-layer co-extruded, biaxially stretched, tubular seamless casing for sausages to be heated in water and cooking-sausages, having improved tearing properties in the filled state associated with a decreased tendency to burst open when the sausage product is first cut, containing at least two layers composed predominantly of aliphatic polyamide, which form the inner and outer surfaces of the tube, and at least two additional layers, which are enclosed by the inner and outer polyamide layers, with at least one of the enclosed layers acting as a water vapor barrier and having the structure of a polyolefin and at least one other of the enclosed layers acting as an oxygen barrier and consisting mainly of ethylene vinyl alcohol copolymers, the quotient of the tear resistance in the transverse direction to the tear resistance in the longitudinal direction lying between about 0.65 and 0.85, with the degree of surface stretching of the film product being between 8 and 11.

Abstract: A sound generator consists of a housing defining open first and second ends and an internal passage extending therebetween. A speaker is positioned within the housing, and a control arrangement including a circuit board is interconnected with the speaker. The circuit board is preferably located within the internal cavity, and a manually actuable switching arrangement is accessible from the exterior of the housing and interconnected with the circuit board for controlling the output therefrom to the speaker to control the sound generated by the speaker. In one form, the switches are accessible via a control portion formed on a wall of the housing, and in another form the switches are accessible through a movable shield member or sleeve mounted to the housing having an opening providing access to certain of the switches.

Abstract: A game which simulates the sights and sounds of vehicles such as automobiles racing on one or more tracks, in which a vehicle is steered to avoid simulated crashing into the oncoming vehicles on the tracks, thus completing one or more laps of the race within a fixed time interval. The game includes an enclosure and a transparent panel which is an inclined front part of the enclosure and is both light transmissive and light reflective. Light is admitted into the enclosure from above. A plurality of movable belts having a horizontal reach are mounted within the enclosure, together with means to move the belts along their reaches. At least one toy vehicle is mounted on each belt, so that the motion of the toy vehicles as the belts move is visible through the inclined transparent panel. Another toy vehicle is disposed below the inclined transparent panel so that its image is reflected from the panel in juxtaposition with the toy vehicles on the belts.

Abstract: A doll with a simulated identity or plurality of identities. The simulation is attained by providing a transparent panel which is both light transmissive and light reflective and which is viewed by the child playing with the doll, which doll is mounted in front of the transparent panel. The transparent panel defines the front of an enclosure so that the movable panel, when in position, is generally parallel to and spaced from the transparent panel. The movable panel bears a recognizable portion of the identity desired. The balance of the surface of the movable panel is light absorptive, and the balance of the interior of the enclosure is also light absorptive. The doll is placed in front of the transparent panel and spaced therefrom by a distance generally equal to the distance between the two panels, so that the image of the doll reflected from the transparent panel appears to be coincident with the identity portion of the movable panel within the enclosure.