Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: A component formed of a refractory metal has a surface that is at least partially coated with a layer of titanium diboride. There is also described a method of manufacturing the component and the application of TiB2 as a release agent in high-temperature applications.

Abstract: A component formed of a refractory metal has a surface that is at least partially coated with a layer of yttria. There is also described a method of manufacturing a coated component, and the application of Y2O3 as a release agent in high temperature applications.

Abstract: A roof module for forming a vehicle roof on a motor vehicle has a panel component whose outer surface at least partially forms the roof skin of the vehicle roof, the roof module has at least one environment sensor, and the environment sensor being configured to send and/or receive electromagnetic signals for detecting the vehicle environment, and the panel component being made of a material which is impermeable to the electromagnetic signals of the environment sensor. The panel component has at least one cutout through which the electromagnetic signals of the environment sensor can pass.

Abstract: A system includes a processor in communication with one or more sensors. The processor is programmed to receiving, from the one or more sensors, vibrational information and sound information associated with the vibrational information from a test device, generating a training data set utilizing at least the vibrational data and the sound information associated with the vibrational data, wherein the training data set is sent to a machine learning model configured to output sound predictions, receiving real-time vibrational data from a run-time device running an actuator or electric dive emitting the real-time vibrational data, and based on the machine learning model and the real-time vibrational data, output a sound prediction indicating a purported sound emitted from the run-time device.

Abstract: A system includes a processor, wherein the processor is programmed to receive sound information and vibrational information from a device in a first environment, generate a training data set utilizing at least the vibrational information and a sound perception score associated with the corresponding sound of the vibrational information, wherein the training data set is fed into an un-trained machine learning model, in response to meeting a convergence threshold of the un-trained machine learning model, outputting a trained machine learning model, receive real-time vibrational information from the device in a second environment, and based on the real-time vibrational information as an input to the trained machine learning model, output a real-time sound perception score indicating characteristics associated with sound emitted from the device.

Abstract: An antenna structure for a contactless wearable structure having a plurality of antenna tracks on the substrate, the opposite ends of which are connectable to form an antenna when the substrate is bent, a plurality of capacitor elements on the substrate that are couplable to the antenna for adjusting the resonance frequency of the antenna, and at least one predefined separation region, by means of which it is possible to adjust which of the plurality of capacitor elements are electrically conductively connectable to the antenna when the substrate is bent, in order to form at least one capacitor with a predetermined total capacitance that is electrically conductively coupled to the antenna.

Abstract: The invention relates to a battery device (10) for a motor vehicle, having a plurality of battery cells (12) which are accommodated in a housing and rest at least against a heat-conducting potting compound (20) or a heat-conducting pad, which potting compound or pad rests against at least one structural component (22) of the battery device (10), as a result of which heat (14) can be dissipated from the battery cells (12) to the structural component (22) via the heat-conducting potting compound (20) or the heat-conducting pad.

Abstract: Disclosed is an assembly for granulating polymer material, having a housing; a gas feed conduit having a rectangular cross-section and leading into the housing; a gas discharge conduit located downstream of the housing and having a rectangular cross-section; a granulating unit disposed in the housing and having a perforated plate feeding into the housing and a scraper, which comminutes the material emerging through openings of the perforated plate. In a plane running parallel to the plane of the perforated plate, the two lateral wall faces of the gas discharge conduit arranged perpendicularly to said plane enclose an angle ?2 with one another, and the two lateral wall faces of the gas feed conduit arranged perpendicularly to said plane or plane of section enclose an angle ?1, the two angles ?1 and ?2 being open towards the housing, and the angle ?1 being larger than the angle ?2.

Abstract: A powder-metallurgical sintered molybdenum part which is present as a solid body has the following composition: a molybdenum content of ?99.93% by weight, a boron content “B” of ?3 ppmw and a carbon content “C” of ?3 ppmw, with a total content “BaC” of carbon and boron being in a range of 15 ppmw?“BaC”?50 ppmw, an oxygen content “O” in a range of 3 ppmw?“O”?20 ppmw, a maximum tungsten content of ?330 ppmw and a maximum proportion of other impurities of ?300 ppmw. A powder-metallurgical process for producing such a sintered molybdenum part is also provided.

Abstract: A chip arrangement including a chip module which includes a chip, a contact-based interface in accordance with ISO 7816 which is electrically conductively connected to the chip, and an antenna structure which is electrically conductively connected to the chip and provides a contactless interface, and a carrier which comprises a chip module receptacle and a booster antenna structure which, when the chip module is arranged in the chip module receptacle of the carrier, inductively couples to the antenna structure of the chip module, wherein the chip module is arranged releasably in the chip module receptacle.

Abstract: Raw sensor data from a device of a user is collected. The raw data does not include location data for the device. The data is preprocessed to identify driving trips in which the user had the device. The trip data is provided to machine-learning models (MLMs) as input and the MLMs provide as output predictions for each trip's estimated speeds, estimated number of hard brakes and a degree of each hard brake, and estimated degrees of distracted driving. A duration, time of day, and calendar date of each trip is identified. The predictions, duration, time of day, and calendar date are modified into four factor values. The four modified factor values are combined into an overall driver characteristic value and provided to a network service associated with the user for purposes of providing or modifying services provided to the user through the network service based on the overall characteristic value.

Abstract: At least one example embodiment provides a method including obtaining a first image, the first image including a light field on a patient, the light field being generated by a treatment system; obtaining a treatment plan outline, the treatment plan outline including an area of the patient for a treatment; determining positioning information based on the first image and the treatment plan outline, the positioning information including an indicator of a position of the treatment system with respect to the patient; and controlling the treatment system based on the positioning information.

Abstract: At least one example embodiment provides a method including obtaining a surface of a patient, obtaining first treatment information for the patient, the first treatment information associated with a treatment for the patient, the first treatment information corresponding to at least one of a treatment intent for the patient, a treatment plan for the patient or a structure of the patient, obtaining at least one model based on the first treatment information for the patient and determining a region of interest of the patient based on the surface of the patient and the at least one model.

Abstract: At least one example embodiment provides a method including obtaining surface information of a patient using a camera; determining a motion of the patient based on the surface information; and providing an indicator of a region of interest (ROI) of the patient based on the motion.

Abstract: Device (10) for spraying or applying of media by means of compressed air, in particular at insides or inner sides of medical products or vessels, with a two-substance nozzle (1) formed from at least two cannulas (2, 3) inserted one in the other with substantially constant diameter along their longitudinal extension, with a nozzle body (4) formed as a holding means for the two-substance nozzle (1), which has at least in each case an inlet for the medium (11) and for the compressed air (12), wherein at the nozzle body (4), clamping inserts (5, 6) respectively adapted in shape to receiving means (7, 8) are arranged for a sealingly holding and fixedly holding of an inner cannula (2) for media and of an outer cannula (3) for compressed air in the form of hollow needles, which are provided in the correspondingly shaped receiving means (7, 8) for attaching the cannulas (2, 3) inserted one in the other with the formation of a predefined gap (14) between inner cannula (2) and outer cannula (3).

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: The invention relates to a method for determining an access right to a service, the method comprises: receiving a service request, generating at least one token, the at least one token being broadcast by at least one beacon device; receiving a message comprising at least data interpretable as a token, data from which the at least one beacon device is identifiable and data from which a position of the terminal device is derivable. By applying the received pieces of data it is possible to determine if an access to the service may be granted to the terminal device. The invention also relates to a network controller, a communication system and a computer program product.

Abstract: A delivery vehicle with a vehicle body comprising a cab portion and a rear cargo portion. The cab portion includes a driver's side and a passenger's side. There is a passenger's door for entering and exiting the passenger's side by climbing one or more steps adjacent the passenger's door. In some embodiments, there is an inside passenger door handle is provided that extends within the cab portion and is configured to actuate a latch assembly between its latched and unlatched positions. In some embodiments, at least a portion of the inside passenger door handle extends into the cab area to be reachable without stooping down the one or more steps adjacent the passenger's door.

Abstract: A semiconductor component may include a first compressive strain layer on top of a semiconductor body. A material for the first compressive strain layer may include Ta, Mo, Nb, compounds thereof, and combinations thereof.