Patents by Inventor Michael Humora

Michael Humora has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRIMIDINYL TYROSINE KINASE INHIBITORS
    Publication number: 20230174511
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton’s tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Application
    Filed: August 8, 2022
    Publication date: June 8, 2023
    Applicants: Viracta Therapeutics, Inc., Biogen MA Inc., Biogen MA Inc.
    Inventors: Brian T. HOPKINS, Timothy R. CHAN, Tracy J. JENKINS, Patrick CONLON, Xiongwei CAI, Michael HUMORA, Xianglin SHI, Ross A. MILLER, Andrew THOMPSON
  • METHODS FOR SYNTHESIS OF CHK1 INHIBITORS
    Publication number: 20230150994
    Abstract: The present technology relates to processes, compounds, compositions, and methods useful for coupling reactions. Also, the present disclosure provides for novel intermediates, compositions of matter, and processes relating to the Chk1 inhibitor, SRA737.
    Type: Application
    Filed: April 6, 2021
    Publication date: May 18, 2023
    Inventors: Michael SCHWAEBE, Thorsten ROSNER, Dalian ZHAO, Ross MILLER, Rich DULINA, Michael HUMORA, Stephen E. GOTTSCHLING
  • PYRIMIDINYL TYROSINE KINASE INHIBITORS
    Publication number: 20210017155
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Application
    Filed: February 27, 2020
    Publication date: January 21, 2021
    Inventors: Brian T. HOPKINS, Timothy R. CHAN, Tracy J. JENKINS, Patrick CONLON, Xiongwei CAI, Michael HUMORA, Xianglin SHI, Ross A. MILLER, Andrew THOMPSON
  • Pyrimidinyl tyrosine kinase inhibitors
    Patent number: 10618887
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: April 14, 2020
    Assignees: Sunesis Pharmaceuticals, Inc., Biogen MA Inc.
    Inventors: Brian T. Hopkins, Timothy R. Chan, Tracy J. Jenkins, Patrick Conlon, Xiongwei Cai, Michael Humora, Xianglin Shi, Ross A. Miller, Andrew Thompson
  • Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
    Patent number: 10208003
    Abstract: The present invention is related to an improved process for the preparation of amino-substituted 4,5,6,7-tetrahydrobenzothiazole compounds of formula I, such as the compound 2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention further relates to an improved synthesis of (R)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention also relates to the methods and intermediates associated with the synthetic process.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: February 19, 2019
    Assignee: Knopp Biosciences LLC
    Inventors: Weirong Chen, Michael Humora, Daw-Iong Albert Kwok, William F. Kiesman, Erwin Ayandra Irdam
  • PYRIMIDINYL TYROSINE KINASE INHIBITORS
    Publication number: 20190047986
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Application
    Filed: March 5, 2018
    Publication date: February 14, 2019
    Inventors: Brian T. HOPKINS, Timothy R. CHAN, Tracy J. JENKINS, Patrick CONLON, Xiongwei CAI, Michael HUMORA, Xianglin SHI, Ross A. MILLER, Andrew THOMPSON
  • Inhibitors of Bruton's tyrosine kinase
    Patent number: 10189817
    Abstract: The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: January 29, 2019
    Assignee: BIOGEN MA INC.
    Inventors: Brian T. Hopkins, Xiongwei Cai, Timothy R. Chan, Patrick Conlon, Michael Humora, Tracy J. Jenkins, J. Michael Macphee, Xianglin Shi, Ross A. Miller, Andrew Thompson
  • INHIBITORS OF BRUTON'S TYROSINE KINASE
    Publication number: 20180291001
    Abstract: The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms.
    Type: Application
    Filed: January 19, 2018
    Publication date: October 11, 2018
    Inventors: Brian T. Hopkins, Xiongwei Cai, Timothy R. Chan, Patrick Conlon, Michael Humora, Tracy J. Jenkins, J. Michael Macphee, Xianglin Shi, Ross A. Miller, Andrew Thompson
  • FORMS AND COMPOSITIONS OF BIARYL INHIBITORS OF BRUTON'S TYROSINE KINASE
    Publication number: 20180282310
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Application
    Filed: June 10, 2016
    Publication date: October 4, 2018
    Inventors: J. Michael MacPhee, Michael Humora
  • Pyrimidinyl tyrosine kinase inhibitors
    Patent number: 9944622
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: April 17, 2018
    Assignees: Biogen MA Inc., Sunesis Pharmaceuticals, Inc.
    Inventors: Brian T. Hopkins, Timothy R. Chan, Tracy J. Jenkins, Patrick Conlon, Xiongwei Cai, Michael Humora, Xianglin Shi, Ross A. Miller, Andrew Thompson
  • SYNTHESIS OF AMINE SUBSTITUTED 4,5,6,7-TETRAHYDROBENZOTHIAZOLE COMPOUNDS
    Publication number: 20170158648
    Abstract: The present invention is related to an improved process for the preparation of amino-substituted 4,5,6,7-tetrahydrobenzothiazole compounds of formula I, such as the compound 2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention further relates to an improved synthesis of (R)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention also relates to the methods and intermediates associated with the synthetic process.
    Type: Application
    Filed: October 24, 2016
    Publication date: June 8, 2017
    Inventors: Weirong CHEN, Michael HUMORA, Daw-Iong Albert KWOK, William F. KIESMAN, Erwin Ayandra IRDAM
  • INHIBITORS OF BRUTON'S TYROSINE KINASE
    Publication number: 20170114039
    Abstract: The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms.
    Type: Application
    Filed: May 27, 2016
    Publication date: April 27, 2017
    Inventors: Brian T. Hopkins, Xiongwei Cai, Timothy R. Chan, Patrick Conlon, Michael Humora, Tracy J. Jenkins, J. Michael Macphee, Xianglin Shi, Ross A. Miller, Andrew Thompson
  • Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
    Patent number: 9512096
    Abstract: The present invention is related to an improved process for the preparation of amino-substituted 4,5,6,7-tetrahydrobenzothiazole compounds of formula I, such as the compound 2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention further relates to an improved synthesis of (R)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention also relates to the methods and intermediates associated with the synthetic process.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: December 6, 2016
    Assignee: Knopp Biosciences, LLP
    Inventors: Weirong Chen, Michael Humora, Daw-long Albert Kwok, William F. Kiesman, Erwin Ayandra Irdam
  • PYRIMIDINYL TYROSINE KINASE INHIBITORS
    Publication number: 20160304494
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Application
    Filed: June 29, 2016
    Publication date: October 20, 2016
    Inventors: Brian T. Hopkins, Timothy R. Chan, Tracy J. Jenkins, Patrick Conlon, Xiongwei Cai, Michael Humora, Xianglin Shi, Ross A. Miller, Andrew Thompson
  • Pyrimidinyl tyrosine kinase inhibitors
    Patent number: 9394277
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: July 19, 2016
    Assignees: Biogen MA Inc., Sunesis Pharmaceuticals, Inc.
    Inventors: Brian T. Hopkins, Patrick Conlon, Timothy R. Chan, Tracy J. Jenkins, Xiongwei Cai, Michael Humora, Xianglin Shi, Ross A. Miller, Andrew Thompson
  • Inhibitors of Bruton's tyrosine kinase
    Patent number: 9353087
    Abstract: The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: May 31, 2016
    Assignees: Biogen MA Inc., Sunesis Pharmaceuticals, Inc.
    Inventors: Brian T. Hopkins, Xiongwei Cai, Timothy R. Chan, Patrick Conlon, Michael Humora, Tracy J. Jenkins, Michael J. Macphee, Xianglin Shi, Ross A. Miller, Andrew Thompson
  • PYRIMIDINYL TYROSINE KINASE INHIBITORS
    Publication number: 20150158843
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Application
    Filed: June 7, 2013
    Publication date: June 11, 2015
    Inventors: Brian T. Hopkins, Patrick Conlon, Timothy R. Chan, Tracy J. Jenkins, Xiongwei Cai, Michael Humora, Xianglin Shi, Ross A. Miller, Andrew Thompson
  • INHIBITORS OF BRUTON'S TYROSINE KINASE
    Publication number: 20150126528
    Abstract: The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms.
    Type: Application
    Filed: June 7, 2013
    Publication date: May 7, 2015
    Inventors: Brian T. Hopkins, Xiongwei Cai, Timothy R. Chan, Patrick Conlon, Michael Humora, Tracy J. Jenkins, Michael J. Macphee, Xianglin Shi, Ross A. Miller, Andrew Thompson
  • SYNTHESIS OF AMINE SUBSTITUTED 4,5,6,7-TETRAHYDROBENZOTHIAZOLE COMPOUNDS
    Publication number: 20150126745
    Abstract: The present invention is related to an improved process for the preparation of amino-substituted 4,5,6,7-tetrahydrobenzothiazole compounds of formula I, such as the compound 2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention further relates to an improved synthesis of (R)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention also relates to the methods and intermediates associated with the synthetic process.
    Type: Application
    Filed: December 21, 2012
    Publication date: May 7, 2015
    Inventors: Weirong Chen, Michael Humora, Daw-Iong Albert Kwok, William F. Kiesman, Erwin Ayandra Irdam
  • N-[2-[[(DIAMINOMETHYLENE)AMINO]OXY]ETHYL]-3-[(2,2-DIFLUORO-2-PHENYLETHYL)AMINO]-6-METHYL-2-OXO-1(2H)-PYRAZINEACETAMIDE
    Publication number: 20080021044
    Abstract: The present invention is directed to N-[2-[[(diaminomethylene)amino]oxy]ethyl]-3-[(2,2-difluoro-2-phenylethyl)amino]-6-methyl-s-oxo-1(2H)-pyrazineacetamide, pharmaceutical compositions containing said compound and methods of treatment comprising inhibiting a serine protease using said compound. The present invention is further directed to a process for the preparation of the N-[2-[[(diaminomethylene)amino]oxy]ethyl]-3-[(2,2-difluoro-2-phenylethyl)amino]-6-methyl-2-oxo-1(2H)-pyrazineacetamide as a free base. The present invention is further directed to a process for the preparation of pharmaceutically acceptable salts of N-[2-[[(aminoiminomethyl)amino]oxy]ethyl]-3-[(2,2-difluoro-2-phenylethyl)amino]-6-methyl-2-oxo-1(2H)-pyrazineacetamide.
    Type: Application
    Filed: May 21, 2007
    Publication date: January 24, 2008
    Inventors: Mitul Patel, Christopher Nilsen, Mayra Reyes, Michael Humora, Yun Qian, Fuqiang Liu, Xini Zhang, Kirk Sorgi