Abstract: This invention relates to novel compounds according to Formula (I) which are antagonists of MrgX2, to pharmaceutical compositions containing them, and to their use in therapy for the treatment of MrgX2-mediated diseases and disorders.

Abstract: Provided herein modified dehalogenases have extended surface loop regions that provide a location for internal fusion insertions and modulate binding interaction and activation of environmentally-sensitive chemistries.

Abstract: A surgical port includes an end face comprising a channel extending through the end face, the channel having a cross section shaped to receive a surgical instrument cannula, and a lateral wall extending around a perimeter of the end face, the lateral wall and end face enclosing an open volume. An end portion of a wound retractor is received in the open volume of the surgical port and in engagement with an inner surface of the lateral wall, and the surgical port is configured to abut a body wall in an inserted position of the wound retractor through the body wall.

Abstract: A surgical port includes an end face with a channel extending through the end face. The channel has a cross section shaped to receive a surgical instrument cannula. A lateral wall extends around a perimeter of the end face. The lateral wall and end face enclose an open volume. A rim extends radially inward from the lateral wall and projects into the open volume. An apron portion extends radially outward from the lateral wall and in a direction axially away from the end face. Surgical systems may include surgical ports. Methods relate to using surgical ports.

Abstract: A method of electrically grounding a medical instrument includes inserting a medical instrument through a channel of a surgical port extending from a first end of the surgical port to a second end of the surgical port and while the medical instrument is inserted through the channel, contacting the medical instrument with an electrically conductive material portion protruding into an interior of the channel and extending through a sidewall of the surgical port. Contact of the medical instrument with the electrically conductive material portion does not extend around an entire circumference of the medical instrument.

Abstract: A surgical port includes a first end, a second end opposite the first end, and a longitudinal axis extending through the first end and the second end. An outer sidewall extends between the first end and the second end. First and second channels extend through the port from the first end to the second end. A first electrically conductive portion extends from the first channel to the outer sidewall, and a second electrically conductive portion extends from the second channel to the outer sidewall. The first electrically conductive portion provides a first electrically conductive path between the first channel and the outer sidewall and the second electrically conductive portion provides a second electrically conductive path the second channel and the outer sidewall. The second electrically conductive path is separate from the first electrically conductive path. Devices and methods relate to surgical ports.

Abstract: The present disclosure generally provides oral inserts useful for determining forces experienced by a user, such as a human user, to the head, for example, by measuring one or more of acceleration, velocity, displacement, or rotation. In some aspects, the disclosure provides oral inserts that, when worn properly by a human user, calculate the forces experienced by the user's head with high accuracy. In some aspects, the disclosure provides systems for detecting and calculating forces experienced by the user's head and to determine whether such forces are above a certain threshold indicative of increased concussion risk. In some aspects, the disclosure provides methods for calculating forces experienced by the user's head and determining whether such forces are above a certain threshold indicative of concussion.

Abstract: A surgical port includes an end face with a channel extending through the end face. The channel has a cross section shaped to receive a surgical instrument cannula. A lateral wall extends around a perimeter of the end face. The lateral wall and end face enclose an open volume. A rim extends radially inward from the lateral wall and projects into the open volume. An apron portion extends radially outward from the lateral wall and in a direction axially away from the end face. Surgical systems may include surgical ports. Methods relate to using surgical ports.

Abstract: A surgical port includes an end face with a channel extending through the end face. The channel has a cross section shaped to receive a surgical instrument cannula. A lateral wall extends around a perimeter of the end face. The lateral wall and end face enclose an open volume. A rim extends radially inward from the lateral wall and projects into the open volume. An apron portion extends radially outward from the lateral wall and in a direction axially away from the end face. Surgical systems may include surgical ports. Methods relate to using surgical ports.

Abstract: Methods of shaping a glass sheet are described comprising heating the glass sheet to a temperature for shaping; positioning the glass sheet on a shaping support; shaping the glass sheet on the shaping support, wherein during the shaping of the glass sheet at least one portion of the glass sheet is deliberately cooled. In preferred embodiments, the shaping of the glass sheet involves press bending a heat softened glass sheet between a lower shaping support and an upper shaping member, and wherein during the shaping of the glass sheet on the shaping support only a portion of the major surface of the glass sheet facing the lower shaping support is cooled by directing one or more jet of air onto said portion.

Abstract: A surgical port includes a first end, a second end opposite the first end, and a longitudinal axis extending through the first end and the second end. An outer sidewall extends between the first end and the second end. First and second channels extend through the port from the first end to the second end. A first electrically conductive portion extends from the first channel to the outer sidewall, and a second electrically conductive portion extends from the second channel to the outer sidewall. The first electrically conductive portion provides a first electrically conductive path between the first channel and the outer sidewall and the second electrically conductive portion provides a second electrically conductive path the second channel and the outer sidewall. The second electrically conductive path is separate from the first electrically conductive path. Devices and methods relate to surgical ports.

Abstract: A surgical port includes a first end, a second end opposite the first end, and a longitudinal axis extending through the first end and the second end. An outer sidewall extends between the first end and the second end. First and second channels extend through the port from the first end to the second end. A first electrically conductive portion extends from the first channel to the outer sidewall, and a second electrically conductive portion extends from the second channel to the outer sidewall. The first electrically conductive portion provides a first electrically conductive path between the first channel and the outer sidewall and the second electrically conductive portion provides a second electrically conductive path the second channel and the outer sidewall. The second electrically conductive path is separate from the first electrically conductive path. Devices and methods relate to surgical ports.

Abstract: The present disclosure generally provides oral inserts useful for determining forces experienced by a user, such as a human user, to the head, for example, by measuring one or more of acceleration, velocity, displacement, or rotation. In some aspects, the disclosure provides oral inserts that, when worn properly by a human user, calculate the forces experienced by the user's head with high accuracy. In some aspects, the disclosure provides systems for detecting and calculating forces experienced by the user's head and to determine whether such forces are above a certain threshold indicative of increased concussion risk. In some aspects, the disclosure provides methods for calculating forces experienced by the user's head and determining whether such forces are above a certain threshold indicative of concussion.

Abstract: A surgical port includes a first end, a second end opposite the first end, and a longitudinal axis extending through the first end and the second end. An outer sidewall extends between the first end and the second end. First and second channels extend through the port from the first end to the second end. A first electrically conductive portion extends from the first channel to the outer sidewall, and a second electrically conductive portion extends from the second channel to the outer sidewall. The first electrically conductive portion provides a first electrically conductive path between the first channel and the outer sidewall and the second electrically conductive portion provides a second electrically conductive path the second channel and the outer sidewall. The second electrically conductive path is separate from the first electrically conductive path. Devices and methods relate to surgical ports.

Abstract: A surgical port includes an end face with a channel extending through the end face. The channel has a cross section shaped to receive a surgical instrument cannula. A lateral wall extends around a perimeter of the end face. The lateral wall and end face enclose an open volume. A rim extends radially inward from the lateral wall and projects into the open volume. An apron portion extends radially outward from the lateral wall and in a direction axially away from the end face. Surgical systems may include surgical ports. Methods relate to using surgical ports.

Abstract: A method of categorising speed of a terminal (202) in a wireless communications network (116) comprises monitoring a first factor associated with allocation of a radio-frequency (RF) resource that is not related to mobility of the terminal (202). The first factor is then offset against a second factor, the second factor being potentially indicative of mobility of the terminal (202). The speed of the terminal (202) is then approximated using the result of offsetting the first factor against the second factor.

Abstract: In order to discover at least part of a frequency list used by an active wireless device in a cellular communications network for neighbour cell signal measurements, measurement reports are extracted from messages carrying reports of measurements relating to propagation of wireless signals between the network and the device. Additional information (such as identity of sections of the network adjacent to a current serving cell for the device) is extracted from other messages, and the extracted measurement reports and additional information are combined to discover the required frequency list.

Abstract: A method of categorising speed of a terminal (202) in a wireless communications network (116) comprises monitoring a first factor associated with allocation of a radio-frequency (RF) resource that is not related to mobility of the terminal (202). The first factor is then offset against a second factor, the second factor being potentially indicative of mobility of the terminal (202). The speed of the terminal (202) is then approximated using the result of offsetting the first factor against the second factor.

Abstract: Apparatus for determining a protocol of messages traversing a signalling link in a telecommunications network includes a memory for storing one or more predetermined characteristic of a message in the protocol that can be used to distinguish that protocol from other protocols. A protocol auto-discovery module is coupled to the memory and to a module that extracts channels from signalling link timeslots. The protocol auto-discovery module determines whether the predetermined characteristic is present in the sampled message and identifies the signalling link as carrying messages in the particular protocol if the predetermined characteristic is present in the sampled message. The identification may be based on a confidence measure stored in a channel configuration table which is incremented when a message on the signalling link is identified as being in that particular protocol and decremented when a message is identified as being in another protocol.

Abstract: Apparatus and method for testing of a telecommunications network, which uses a passive monitoring system to generate actual customer usage data concerning the telecommunications network. An active test manager uses the actual customer usage data to instantiate a set of test templates from a store of predetermined test templates, the test template describing a sequence of user actions performed in the network. The test templates include at least one test variable, which is updated by the active test manager, using the actual customer usage data, to generate a test, or set of tests. The generated test, or set of tests are then used by an active testing module to actively test the telecommunications network, hence the tests are updated using the latest data on customer usage.