Abstract: A seal is provided for a well plate having a plurality of wells with each well having an opening in one end therein for influxing a fluid and another end thereof for effluxing the fluid. The seal includes a planar member having a top and bottom and a plurality of recess formed in the top and a plurality of cups formed in the bottom. A plurality of recesses are uniformly spaced apart from one another and each recess is sized for sealably engaging a corresponding well tip. The plurality of cups are uniformly spaced apart from another and sized for sealably engaging a corresponding well opening in order to enable the member to effect a sealed engagement with all of the well openings or all of the well tips.