Abstract: The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate, 1,4-butanediol, or other product pathway and being capable of producing 4-hydroxybutyrate, 1,4-butanediol, or other product, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate, 1,4-butanediol, or other product or related products using the microbial organisms.

Abstract: A system, method and computer program product are disclosed for governing a supply chain consortium utilizing a network where an algorithm that is acceptable to each of a plurality of distributors/suppliers is determined. A contract is then established that requires a supply chain manager to manage the distributors/suppliers utilizing the algorithm. The distributors/suppliers are then selected for operating in the supply chain utilizing the algorithm and supply chain data gathered utilizing a network. The supply chain manager is allowed to manage the supply chain utilizing the supply chain data. In such an embodiment, the contract may allow the supply chain manager to deviate from the algorithm a predetermined amount.