Abstract: Disclosed are Cathepsin-S reversible inhibitor compounds of the formula (I) which are useful in the treatment of autoimmune and other diseases. Also disclosed are pharmaceutical compositions containing the same, and methods of making and using the same.

Abstract: Compositions for use as cable coverings, e.g. insulation or jacket, are described. The compositions contain a base polymer having (a) a thermoplastic polyurethane (TPU); (b) a chlorinated flame retardant; and (c) an antimony flame retardant.

Abstract: A system and method for providing navigation for visitors to casinos allows the visitors to select a game, amenity, attraction, or facility as a desired destination, and then have a route provided them to that destination. The route can be drawn on a touch screen display. As an avatar proceeds along the route, it passes landmarks that are highlighted through animation. They may grow as the avatar approaches, then shrink back as it continues beyond the landmark. This is typically repeated several times, allowing the customer to easily remember the series of landmarks, and, thus, the route to the desired destination. He can then follow the route by moving from landmark to landmark across the casino floor. A customized map with the route may also be printed.

Abstract: The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

Abstract: The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

Abstract: The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

Abstract: The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

Abstract: Disclosed are Cathepsin-S reversible inhibitor compounds of the formula (I) which are useful in the treatment of autoimmune and other diseases. Also disclosed are pharmaceutical compositions containing the same, and methods of making and using the same.

Abstract: The present invention relates to compositions for use as cable coverings, e.g. insulation or jacket, that meets industry requirements (especially Mil-PRF-85045F) for low water absorption, and high tensile strength and elongation retention properties upon fluid immersion. The compositions contain a base polymer having (a) a thermoplastic polyurethane (TPU); (b) a chlorinated flame retardant; and (c) an antimony flame retardant.

Abstract: A system and method for providing navigation for visitors to casinos allows the visitors to select a game, amenity, attraction, or facility as a desired destination, and then have a route provided them to that destination. The route can be drawn on a touch screen display. As an avatar proceeds along the route, it passes landmarks that are highlighted through animation. They may grow as the avatar approaches, then shrink back as it continues beyond the landmark. This is typically repeated several times, allowing the customer to easily remember the series of landmarks, and, thus, the route to the desired destination. He can then follow the route by moving from landmark to landmark across the casino floor. A customized map with the route may also be printed.

Abstract: This invention relates to novel benzofuran and benzothiophene derivatives of the general formula and their use for the treatment of hyper-proliferative disorders.

Abstract: This invention relates to a compound of Formula I wherein Y is CH or N; Ar1 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents each selected independently from (C1-C3)alkoxy, halo, OH, CF3, CN, NO2 and (C1-C3)alkyl, said alkyl being optionally substituted with CF3; Ar2 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents each independently selected from halo, OH, CN, NO2, CF3, (C1-C6)alkoxy, NR1R1, S(O)2R2, C(O)R3, and (C1-C6)alkyl optionally substituted with R4, and its use in treating hyper-proliferative disorder.

Abstract: This invention relates to a compound of Formula (I) wherein Y is CH or N; Ar1 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents each selected independently from (C1-C3)alkoxy halo, OH, CF3, CN, NO2 and (C1-C3)alkyl, said alkyl being optionally substituted with CF3; Ar2 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents each independently selected from halo, OH, CN, NO2, CF3, (C1-C6)alkoxy, NR1R1, S(O)2R2, C(O)R3, and (C1-C6)alkyl optionally substituted with R4, and its use in treating hyper-proliferative disorders.

Abstract: A dual electrospray ionization source for use in connection with a mass spectrometer having an inlet port. The source includes a polymer nozzle holder having a drive axis and a pair of continuously spraying nozzles mounted to the nozzle holder at spaced-apart positions. An adjustment mechanism allows positional adjustment of one nozzle with respect to the other nozzle on the nozzle holder. A programmable motor is connected to the nozzle holder at the drive axis. The motor rotationally and reciprocally drives the nozzle holder to sequentially position each of the nozzles in alignment with an inlet port of mass spectrometer.

Abstract: This invention relates to novel benzofuran and dihydrobenzofuran compounds, pharmaceutical compositions containing such compounds, and methods of treating beta-3 adrenoreceptor-mediated conditions with such compositions.

Abstract: This invention relates to novel benzofuran and dihydrobenzofuran compounds, pharmaceutical compositions containing such compounds, and methods of treating beta-3 adrenoreceptor-mediated conditions with such compositions.

Abstract: This invention relates to the various features of a headset design that utilizes active noise cancellation. This particular design has been developed to work with radio communication systems, but many features are applicable to headsets designed solely for ear protection. The unique design features of the invention allow for uninterrupted communication capability with active noise cancellation. The design also provides it own built in rechargeable power supply that is easily removed for recharging.

Abstract: An elliptically shaped flow modulator in a duct with a circular cross section is used to produce a time varying head loss in a steady fluid flow in the duct, which results in an unsteady volume velocity at the end of the duct which radiates an acoustic field; the flow modulator can be used in place of a conventional acoustic source in an active noise control system.

Abstract: An actively controlled mount system to control vibration which permits static forces from a machine while decoupling the transmission of dynamic vibrational forces. The mount system provides a reduction of force losses from a first generating area to a second force applying area to actively control vibrations of a vibrating element. These force losses are minimized due to minimization of the mass and velocity of fluid pumped by pumping the fluid through short large cross-sectional area passageways. The device provides for channeling of the forces to the vibrating element in a uniaxial direction and constrains the application of forces in non-working directions.

Abstract: An actively controlled mount system to control vibration which permits static forces from a machine while decoupling transmission of dynamic vibration forces. The mount system includes opposed force chamber (156, 160) with pistons which control movement of an engine connected bushing (3) to allow compensatory force generated by the opposed chambers to transfer thereto to attenuate vibration from the engine.