Patents by Inventor Michael J. Driver
Michael J. Driver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8753659Abstract: An intravascular stent has a coating comprising a crosslinked amphiphilic polymer and a sparingly water soluble matrix metalloproteinase inhibitor (MMPI). Preferably the polymer is formed from 2-methacryloyloxy-2?-ethyltrimethylammonium phosphate inner salt, C4-18 alkyl methacrylate and reactive and/or crosslinking monomer and the MMPI is a hydroxamic acid, more preferably batimastat. Preclinical and clinical results are reported, showing good luminal areas and reduced intimal thickening.Type: GrantFiled: May 20, 2013Date of Patent: June 17, 2014Assignee: Abbott LaboratoriesInventors: Andrew L. Lewis, Peter W. Stratford, Michael J. Driver
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Publication number: 20130309289Abstract: An intravascular stent has a coating comprising a crosslinked amphiphilic polymer and a sparingly water soluble matrix metalloproteinase inhibitor (MMPI). Preferably the polymer is formed from 2-methacryloyloxy-2?-ethyltrimethylammonium phosphate inner salt, C4-18 alkyl methacrylate and reactive and/or crosslinking monomer and the MMPI is a hydroxamic acid, more preferably batimastat. Preclinical and clinical results are reported, showing good luminal areas and reduced intimal thickening.Type: ApplicationFiled: May 20, 2013Publication date: November 21, 2013Applicant: Abbott LaboratoriesInventors: Andrew E. Lewis, Peter W. Stratford, Michael J. Driver
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Patent number: 8465758Abstract: A method of producing an intravascular stent has a coat comprising a crosslinked amphiphilic polymer and a sparingly water soluble matrix metalloproteinase inhibitor (MMPI). Preferably the polymer is formed from 2-methacryloyloxy-2?-ethyltrimethylammonium phosphate inner salt, C4-18 alkyl methacrylate and reactive and/or crosslinking monomer and the MMPI is a hydroxamic acid, more preferably batimastat. Preclinical and clinical results are reported, showing good luminal areas and reduced intimal thickening.Type: GrantFiled: May 4, 2010Date of Patent: June 18, 2013Assignee: Abbott LaboratoriesInventors: Andrew L. Lewis, Peter W. Stratford, Michael J. Driver
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Patent number: 8057814Abstract: An intravascular stent has a coat comprising a crosslinked amphiphilic polymer and a sparingly water soluble matrix metalloproteinase inhibitor (MMPI). Preferably the polymer is formed from 2-methacryloyloxy-2?-ethyltrimethylammonium phosphate inner salt, C4-18 alkyl methacrylate and reactive and/or crosslinking monomer and the MMPI is a hydroxamic acid, more preferably batimastat. Preclinical and clinical results are reported, showing good luminal areas and reduced intimal thickening.Type: GrantFiled: May 4, 2010Date of Patent: November 15, 2011Assignee: Abbott LaboratoriesInventors: Andrew L. Lewis, Peter W. Stratford, Michael J. Driver
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Publication number: 20100275431Abstract: A method of producing an intravascular stent has a coat comprising a crosslinked amphiphilic polymer and a sparingly water soluble matrix metalloproteinase inhibitor (MMPI). Preferably the polymer is formed from 2-methacryloyloxy-2?-ethyltrimethylammonium phosphate inner salt, C4-18 alkyl methacrylate and reactive and/or crosslinking monomer and the MMPI is a hydroxamic acid, more preferably batimastat. Preclinical and clinical results are reported, showing good luminal areas and reduced intimal thickening.Type: ApplicationFiled: May 4, 2010Publication date: November 4, 2010Inventors: ANDREW L. LEWIS, Peter W. Stratford, Michael J. Driver
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Publication number: 20100222867Abstract: An intravascular stent has a coat comprising a crosslinked amphiphilic polymer and a sparingly water soluble matrix metalloproteinase inhibitor (MMPI). Preferably the polymer is formed from 2-methacryloyloxy-2?-ethyltrimethylammonium phosphate inner salt, C4-18 alkyl methacrylate and reactive and/or crosslinking monomer and the MMPI is a hydroxamic acid, more preferably batimastat. Preclinical and clinical results are reported, showing good luminal areas and reduced intimal thickening.Type: ApplicationFiled: May 4, 2010Publication date: September 2, 2010Inventors: ANDREW L. LEWIS, Peter W. Stratford, Michael J. Driver
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Patent number: 7713538Abstract: An intravascular stent has a coat comprising a crosslinked amphiphilic polymer and a sparingly water soluble matrix metalloproteinase inhibitor (MMPI). Preferably the polymer is formed from 2-methacryloyloxy-2?-ethyltrimethylammonium phosphate inner salt, C4-18 alkyl methacrylate and reactive and/or crosslinking monomer and the MMPI is a hydroxamic acid, more preferably batimastat. Preclinical and clinical results are reported, showing good luminal areas and reduced intimal thickening.Type: GrantFiled: January 11, 2002Date of Patent: May 11, 2010Assignee: Abbott LaboratoriesInventors: Andrew L. Lewis, Peter W. Stratford, Michael J. Driver
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Publication number: 20040117006Abstract: An intravascular stent has a coat comprising a crosslinked amphiphilic polymer and a sparingly water soluble matrix metalloproteinase inhibitor (MMPI). Preferably the polymer is formed from 2-methacryloyloxy-2′-ethyltrimethylammonium phosphate inner salt, C4-18 alkyl methacrylate and reactive and/or crosslinking monomer and the MMPI is a hydroxamic acid, more preferably batimastat. Preclinical and clinical results are reported, showing good luminal areas and reduced intimal thickening.Type: ApplicationFiled: January 7, 2004Publication date: June 17, 2004Inventors: Andrew L. Lewis, Peter W. Stratford, Michael J. Driver
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Patent number: 5599587Abstract: A process for the preparation of compounds of formula (I) in which Z is hydrogen or --NHZ is an activated amine group capable of reacting with a surface, the groups R are the same or different and each is a straight or branched C.sub.1 -C.sub.4 alkyl group, preferably methyl, n is from 2 to 6, and X is a straight or branched C.sub.1-20 alkylene group, or X is a group of formula --(CH.sub.2 CH.sub.2 O).sub.b --, or --(CH.sub.2).sub.c --Ar--(CH.sub.2).sub.d -- where b is from 1 to 20, c and d are the same or different and each is from 0 to 5, and Ar is a para- or meta- disubstituted phenyl group (preferably a para-disubstituted phenyl group) which is optionally further substituted by one or more C.sub.1 -C.sub.4 alkyl groups, or an acid addition salt thereof or a hydrate thereof, new compounds of formula (I) and salts and hydrates thereof and the use of compounds of formula (I) and salts and hydrates thereof in treating surfaces to render them more biocompatible.Type: GrantFiled: April 30, 1993Date of Patent: February 4, 1997Assignee: Biocompatibles LimitedInventors: Roderick W. J. Bowers, Peter W. Stratford, Stephen A. Jones, Jeremy C. Russell, Michael J. Driver
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Patent number: 5591882Type: GrantFiled: April 18, 1995Date of Patent: January 7, 1997Assignee: Biocompatibles LimitedInventors: Peter W. Straford, Michael J. Driver
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Patent number: 5422402Abstract: A process of treating suitable synthetic polymers comprising the steps of (a) where appropriate, activating the surface to be treated, and, if necessary, providing spacer groups thereon; and (b) treating the surface with a compound of Formula (I), ##STR1## wherein Y' is an alkylene group optionally containing an aryl group, a poly(ethylene glycol) or a glycerol group; R may be the same or different and each is a straight or branched C.sub.1-4 alkyl group, n is from 1 to 4 and X is a group which reacts with functional groups of the polymer. Polymeric surfaces and materials thus produced and shaped articles containing such surfaces and materials.Type: GrantFiled: September 23, 1992Date of Patent: June 6, 1995Assignee: Biocompatibles LimitedInventors: Roderick W. J. Bowers, Stephen A. Jones, Peter W. Straford, Michael J. Driver
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Patent number: 5418295Abstract: A process for treating polymeric contact lenses comprising the steps of: (a) where necessary, activating the polymeric surface to be treated and (b) treating the surface with a compound of formula (I), wherein X is a group which reacts with the polymer surface; Y is straight or branched C.sub.1-6 alkylene; the groups R are the same or different and each is straight or branched C.sub.1-4 alkyl, and A.sup.- is a counterion.X--Y--CH.sub.2 N.sup..sym. R.sub.3 A.sup..crclbar.Type: GrantFiled: April 13, 1992Date of Patent: May 23, 1995Assignee: Biocompatibles LimitedInventors: Roderick W. J. Bowers, Stephen A. Jones, Peter W. Straford, Michael J. Driver
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Patent number: 5204330Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein: R.sub.1 is a group --CH.sub.2 --X where X is hydrogen, halogen, --CN, --N.sub.3, --OC(O)R.sub.5, --S(O).sub.n R.sub.5, --SH, --OC(O)NHR.sub.5, --NHCONHR.sub.5 or --NR.sub.6 R.sub.7, where R.sub.5 is hydrogen optionally substituted C.sub.1-8 alkyl, or aryl, heteroaryl, aryl C.sub.1-4 alkyl or heteroaryl C.sub.1-4 alkyl in each of which the aromatic moiety is optionally substituted with the proviso that when X is --S(O).sub.n R.sub.5, R.sub.5 does not represent hydrogen, R.sub.6 and R.sub.7 are independently hydrogen or C.sub.116 alkyl, or one of R.sub.6 and R.sub.7 is hydrogen and the other is --formyl, C.sub.2-8 alkanoyl, dialkoxyphosphoryl, aroyl, heteroaroyl, aryl C.sub.1-4 alkanoyl, heteroaryl C.sub.1-4 alkanoyl, C.sub.1-8 alkylsulphonyl, arylsulphonyl, heteroarylsulphonyl, aryl C.sub.1-4 alkylsulphonyl or heteroaryl C.sub.1-4 alkylsulphonyl, where any aromatic moiety in R.sub.6 or R.sub.Type: GrantFiled: December 6, 1990Date of Patent: April 20, 1993Assignee: Beecham Group p.l.c.Inventors: Michael J. Driver, Alexander R. Greenlees, David T. MacPherson
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Patent number: 5116960Abstract: Compounds of formula (I) or salts thereof: ##STR1## wherein: each R.sub.1 is independently hydrogen or a silyl protecting group; R.sub.2 is a carboxylic acid or derivative thereof; a ketone or aldehyde function; hydroxymethyl in which the hydroxyl function is optionally silylated, or substituted by hydroxy C.sub.1-4 alkyl, alkoxy C.sub.1-4 alkyl, alkoxycarbonyl C.sub.1-4 alkyl, hydroxycarbonyl C.sub.1-4 alkyl, alkyl, alkanoyl, or optionally substituted aryl or aroyl; one of X and Y is hydrogen, and the other is a sugar residue; hydroxy; optionally substituted C.sub.1-6 alkoxy or C.sub.3-8 cycloalkoxy; alkanoyloxy; thioalkanoyloxy; sulphonyloxy; halogen; or optionally substituted aryloxy, aralkyloxy or aroyloxy; or X and Y together with the carbon atom to which they are bonded are a carbonyl group or derivative thereof, are provided; their use as chemical intermediates and in the treatment of fungal infections is described.Type: GrantFiled: June 9, 1989Date of Patent: May 26, 1992Assignee: Beecham Group p.l.c.Inventors: Michael J. Driver, David T. MacPherson, William S. MacLachlan
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Patent number: 5100876Abstract: Compounds of the formula (I), or pharmaceutically acceptable salts thereof: ##STR1## wherein R.sub.1 is --CH.sub.2 OH; R.sub.2 is hydrogen or C.sub.1-8 alkyl; R.sub.3 is hydrogen or an amine protection group; and each R.sub.4 is hydrogen; their preparation, compositions containing them and their use in the treatment of fungal infections are described.Type: GrantFiled: December 11, 1989Date of Patent: March 31, 1992Assignee: Beecham Group p.l.c.Inventors: Michael J. Driver, William S. MacLachlan, Andrew W. Taylor
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Patent number: 5066646Abstract: compounds of formula (I) or pharmaceutically acceptable salts thereof; ##STR1## wherein R.sub.1 is a gorup -X-Y where X is a carbonyl group and Y is hydrogen, C.sub.1-8 alkyl, C.sub.2-8 alkenyl, or optionally substituted aryl or heteroaryl; R.sub.2 is hydroxy or C.sub.1-8 alkoxy; R.sub.3 is hydrogen or an amine protection group; and each R.sub.4 is hydrogen; their preparation, compositions containing them and their use as antifungal agents are described.Type: GrantFiled: December 11, 1989Date of Patent: November 19, 1991Assignee: Beecham Group p.l.c.Inventors: Michael J. Driver, Alexander R. Greenlees, David T. MacPherson
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Patent number: 4540688Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof have antibacterial activity: ##STR1## wherein R is hydrogen, C.sub.1-6 alkylcarbonyl or C.sub.1-6 alkyl; R.sup.1 is hydrogen or hydrocarbon; R.sup.2 is hydrogen, or optionally substituted hydrocarbon or optionally substituted heterocyclyl or CXR.sup.d, where X is O or S and R.sup.d is hydrogen or optionally substituted hydrocarbon or optionally substituted heterocyclyl; or R.sup.1 and R.sup.2 together with the nitrogen to which they are attached, form an optionally substituted heterocyclyl group. A process for the preparation of such compounds and compositions comprising them, are also described.Type: GrantFiled: April 27, 1983Date of Patent: September 10, 1985Assignee: Beecham Group p.l.c.Inventor: Michael J. Driver