Patents by Inventor Michael J. Grusby

Michael J. Grusby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR TREATING AND PREVENTING FIBROSIS
    Publication number: 20110142833
    Abstract: The present invention provides methods of screening for compositions useful for treating, ameliorating, or preventing fibrosis and/or fibrosis-associated conditions by measuring changes in the level(s) of IL-21 and/or IL-21 receptor (IL-21R) (e.g., the level of expression of IL-21 and/or IL-21R protein and/or mRNA, the level of activity of IL-21 and/or IL-21R, the level of interaction of IL-21 with IL-21R). The invention further provides antagonists of IL-21 or IL-21R for the treatment of fibrosis and/or fibrosis-associated conditions. Further provided herein are methods of diagnosing, prognosing, and monitoring the progress (e.g., the course of treatment) of fibrosis and/or fibrosis-associated conditions by measuring the level of IL-21 and/or IL-21R (i.e., the level of activity of IL-21 and/or IL-21R, the level of expression of IL-21 and/or IL-21R (e.g., the level of IL-21 and/or IL-21R gene products), and/or the level of interaction of IL-21 with IL-21R).
    Type: Application
    Filed: February 18, 2011
    Publication date: June 16, 2011
    Inventors: Deborah A. YOUNG, Thomas A. Wynn, Mary Collins, Michael J. Grusby
  • Methods for treating and preventing fibrosis
    Patent number: 7910105
    Abstract: The present invention provides methods of screening for compositions useful for treating, ameliorating, or preventing fibrosis and/or fibrosis-associated conditions by measuring changes in the level(s) of IL-21 and/or IL-21 receptor (IL-21R) (e.g., the level of expression of IL-21 and/or IL-21R protein and/or mRNA, the level of activity of IL-21 and/or IL-21R, the level of interaction of IL-21 with IL-21R). The invention further provides antagonists of IL-21 or IL-21R for the treatment of fibrosis and/or fibrosis-associated conditions. Further provided herein are methods of diagnosing, prognosing, and monitoring the progress (e.g., the course of treatment) of fibrosis and/or fibrosis-associated conditions by measuring the level of IL-21 and/or IL-21R (i.e., the level of activity of IL-21 and/or IL-21R, the level of expression of IL-21 and/or IL-21R (e.g., the level of IL-21 and/or IL-21R gene products), and/or the level of interaction of IL-21 with IL-21R).
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: March 22, 2011
    Assignees: Wyeth LLC, The United States of America as represented by the Department of Health and Human Services, President and Fellows of Harvard College
    Inventors: Deborah A. Young, Thomas A. Wynn, Mary Collins, Michael J. Grusby
  • Methods and compositions for modulating T helper (T) cell development and function
    Patent number: 7731946
    Abstract: Methods and compositions for modulating T helper (Th) cell development and function using modulators of IL-21, e.g., human IL-21, activity or level.
    Type: Grant
    Filed: November 12, 2007
    Date of Patent: June 8, 2010
    Assignees: Wyeth LLC, The President and Fellows of Harvard College
    Inventors: Michael J. Grusby, Andrea Wurster, Deborah Young, Mary Collins, Matthew Whitters
  • METHODS AND COMPOSITIONS FOR MODULATING T HELPER (Th) CELL DEVELOPMENT AND FUNCTION
    Publication number: 20090197803
    Abstract: Methods and compositions for modulating T helper (Th) cell development and function using modulators of IL-21, e.g., human IL-21, activity or level.
    Type: Application
    Filed: November 12, 2007
    Publication date: August 6, 2009
    Inventors: MICHAEL J. GRUSBY, ANDREA WURSTER, DEBORAH YOUNG, MARY COLLINS, MATTHEW WHITTERS
  • Methods and compositions for modulating T helper (Th) cell development and function
    Patent number: 7314623
    Abstract: Methods and compositions for modulating T helper (Th) cell development and function using modulators of IL-21, e.g., human IL-21, activity or level.
    Type: Grant
    Filed: July 15, 2003
    Date of Patent: January 1, 2008
    Assignee: Wyeth
    Inventors: Michael J. Grusby, Andrea Wurster, Deborah Young, Mary Collins, Matthew Whitters
  • Methods and compositions for modulating T helper (Th) cell development and function
    Publication number: 20040136954
    Abstract: Methods and compositions for modulating T helper (Th) cell development and function using modulators of IL-21, e.g., human IL-21, activity or level.
    Type: Application
    Filed: July 15, 2003
    Publication date: July 15, 2004
    Inventors: Michael J. Grusby, Andrea Wurster, Deborah Young, Mary Collins, Matthew Whitters
  • Stat6 deficient transgenic mice
    Patent number: 5866760
    Abstract: The invention provides methods and compositions for evaluating modulators of the Stat6 signaling pathway; in a particular, transgenic mice comprising a transgene within a Stat6 allele locus, encoding a selectable marker and displacing the SH2-encoding domain of the Stat6 allele. More particularly, the transgene may comprise 3' and 5' regions with sufficient complementarity to the natural Stat6 allele at the locus to effect homologous recombination of the transgene with the Stat6 allele. Such mice provide useful animal models for determining the effect of candidate drugs on a host deficient in Stat6 function. The invention provides a variety of methods for making and using the subject compositions; in particular, methods for determining the effect of a candidate drug on a mouse deficient in Stat6 function and methods of evaluating the side effects of a Stat6 function inhibitor.
    Type: Grant
    Filed: March 21, 1997
    Date of Patent: February 2, 1999
    Assignee: President and Fellows of Harvard College
    Inventors: Michael J. Grusby, Mark H. Kaplan