Abstract: Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed.

Abstract: Provided herein are RET kinase inhibitors according to the formula: pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods for their use in the treatment of diseases that can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders. A, R1, n, X1, X2, X3, X4, and R2 have the meanings given in the specification.

Abstract: A macroporous-structured polymeric aerogel, and methods for making and using the same, having a polymeric matrix that includes macropores is disclosed.

Abstract: A vehicle infant safety seat characterized by an infant receiving cavity which is concealed in a non-use condition, and conversely. The aforesaid cavity includes cushioning, for infant comfort, and a retaining cover for positive cushioning placement in a non-use condition, such also serving protective purposes during a use condition. The instant infant safety seat is typically positioned in the mid-region of the back seat of the vehicle, as in the customary location of an arm rest. Belting and/or webbing, and a safety bar, are provided to selectively assure and limit infant movement.