Patents by Inventor Michael J. Kozal

Michael J. Kozal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIV and Hepatitis C Microarray to Detect Drug Resistance
    Publication number: 20100173795
    Abstract: The invention provides arrays and probes for resequencing gene sequences of HIV and HCV using an array of probes complementary to a set of reference sequences, and to each possible single nucleotide substitution of the reference sequences, and for identifying known mutations in HIV and HCV gene sequences associated with resistance to antiviral therapy. Methods of identifying mutations in HIV and HCV sequences, methods of characterizing HIV and HCV isolates, and methods of evaluating and optimizing a patient's antiviral therapy regimen are also provided.
    Type: Application
    Filed: November 16, 2007
    Publication date: July 8, 2010
    Applicants: Yale University, The United States Government as Represented by the Department of Veterans Affairs
    Inventor: Michael J. Kozal
  • Polymerase chain reaction assays for monitoring antiviral therapy and making therapeutic decisions in the treatment of acquired immunodeficiency syndrome
    Patent number: 6503705
    Abstract: The present invention relates to methods of monitoring, via polymerase chain reaction, the clinical progression of human immunodeficiency virus infection and its response to antiretroviral therapy. According to the invention, polymerase chain reaction assays may be used to predict immunological decline and to identify, at an early stage, patients whose infection has become resistant to a particular antiretroviral drug regimen.
    Type: Grant
    Filed: February 13, 2001
    Date of Patent: January 7, 2003
    Assignee: Leland Stanford Junior University
    Inventors: Michael J. Kozal, Thomas C. Merigan, David A. Katzenstein, Mark Holodniy
  • Polymerase chain reaction assays for monitoring antiviral therapy and making therapeutic decisions in the treatment of acquired immunodeficiency syndrome
    Publication number: 20010018181
    Abstract: The present invention relates to methods of monitoring, via polymerase chain reaction, the clinical progression of human immunodeficiency virus infection and its response to antiretroviral therapy. According to the invention, polymerase chain reaction assays may be used to predict immunological decline and to identify, at an early stage, patients whose infection has become resistant to a particular antiretroviral drug regimen.
    Type: Application
    Filed: February 13, 2001
    Publication date: August 30, 2001
    Inventors: Michael J. Kozal, Thomas C. Merigan, David A. Katzenstein, Mark Holodniy
  • Polymerase chain reaction assays for monitoring antiviral therapy and making therapeutic decisions in the treatment of acquired immunodeficiency syndrome
    Patent number: 5856086
    Abstract: The present invention relates to methods of monitoring, via polymerase chain reaction, the clinical progression of human immunodeficiency virus infection and its response to antiretroviral therapy. According to the invention, polymerase chain reaction assays may be used to predict immunological decline and to identify, at an early stage, patients whose infection has become resistant to a particular antiretroviral drug regimen.
    Type: Grant
    Filed: January 15, 1997
    Date of Patent: January 5, 1999
    Assignee: Leland Stanford Junior University
    Inventors: Michael J. Kozal, Thomas C.. Merigan
  • Polymerase chain reaction assays for monitoring antiviral therapy and making therapeutic decisions in the treatment of acquired immunodeficiency syndrome
    Patent number: 5650268
    Abstract: The present invention relates to methods of monitoring, via polymerase chain reaction, the clinical progression of human immunodeficiency virus infection and its response to antiretroviral therapy. According to the invention, polymerase chain reaction assays may be used to predict immunological decline and to identify, at an early stage, patients whose infection has become resistant to a particular antiretroviral drug regimen.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 22, 1997
    Assignee: Leland Stanford Junior University
    Inventors: Michael J. Kozal, Thomas C. Merigan
  • Polymerase chain reaction assays for monitoring antiviral therapy and making therapeutic decisions in the treatment of acquired immunodeficiency syndrome
    Patent number: 5631128
    Abstract: The present invention relates to methods of monitoring, via polymerase chain reaction, the clinical progression of human immunodeficiency virus infection and its response to antiretroviral therapy. According to the invention, polymerase chain reaction assays may be used to predict immunological decline and to identify, at an early stage, patients whose infection has become resistant to a particular antiretroviral drug regimen.
    Type: Grant
    Filed: August 15, 1994
    Date of Patent: May 20, 1997
    Assignee: Leland Stanford Junior University
    Inventors: Michael J. Kozal, Thomas C. Merigan
  • Polymerase chain reaction assays for monitoring antiviral therapy and making therapeutic decisions in the treatment of acquired immunodeficiency syndrome
    Patent number: RE38352
    Abstract: The present invention relates to methods of monitoring, via polymerase chain reaction, the clinical progression of human immunodeficiency virus infection and its response to antiretroviral therapy. According to the invention, polymerase chain reaction assays may be used to predict immunological decline and to identify, at an early stage, patients whose infection has become resistant to a particular antiretroviral drug regimen.
    Type: Grant
    Filed: September 5, 2002
    Date of Patent: December 16, 2003
    Assignee: Leland Stanford Junior University
    Inventors: Michael J. Kozal, Thomas C. Merigan