Abstract: A FabI inhibitor called fabimycin that has impressive activity against >200 clinical isolates of E. coli, K. pneumoniae, and A. baumannii. Fabimycin has activity in multiple mouse models of infection caused by Gram-negative bacteria, including a model of urinary tract infection. Fabimycin has translational promise, and its discovery provides data indicating that antibiotics whose spectrum of activity is restricted to Gram-positive bacteria can be systematically modified to accumulate in Gram-negative bacteria and be effective against these problematic pathogens.

Abstract: An electric transport device included an outer casing including a top, a bottom, a front, a back, and an interior space. A rear wheel assembly is mounted to the outer casing. The rear wheel assembly extends rearward of the back of the outer casing when the electric transport device is in a riding configuration. A locking mechanism is configurable in a first configuration to engage the rear wheel assembly to lock the rear wheel assembly in a riding position. The locking mechanism is configurable in a second configuration to disengage the locking mechanism from the rear wheel assembly permitting the rear wheel assembly to be moved relative to the outer casing to move the rear wheel assembly from the riding position to a stowed position.

Abstract: A method for training a fault probability model using warranty claim data includes obtaining, by a processing circuit, a first data set for failed building devices based on warranty claim data associated with the building devices; receiving, by the processing circuit, design change data associated with the building devices and determining a design change date based on the design change data; comparing, by the processing circuit, a manufacturing date for each of the failed building devices with the design change date; removing, by the processing circuit, any building devices from the first data set in response to the manufacturing date preceding the design change date to create an updated first data set; generating, by the processing circuit, a training data set comprising the updated first data set; and training, by the processing circuit, a fault probability model using the training data set to produce a trained model.

Abstract: Apparatus and method for efficient graphics processing including ray tracing. For example, one embodiment of a graphics processor comprises: execution hardware logic to execute graphics commands and render images; an interface to couple functional units of the execution hardware logic to a tiled resource; and a tiled resource manager to manage access by the functional units to the tiled resource, a functional unit of the execution hardware logic to generate a request with a hash identifier (ID) to request access to a portion of the tiled resource, wherein the tiled resource manager is to determine whether a portion of the tiled resource identified by the hash ID exists, and if not, to allocate a new portion of the tiled resource and associate the new portion with the hash ID.

Abstract: A spring assembly for a non-rail wheeled or tracked vehicle is provided. The spring assembly includes a piston, and a sleeve with variable thickness. The sleeve is made from an unreinforced synthetic elastomeric material and being free of reinforcing fibers. The sleeve is coupled with a plurality of end components and defines a deformable pressure vessel, and the deformable pressure vessel supplies a support force.

Abstract: A vehicle includes a transmission that performs a method of operating a clutch of a vehicle. The vehicle includes the clutch, an actuator device and a processor. The actuator device includes a piston movable to operate the clutch. The processor is configured to receive a pressure signal indicative of a selected fluid pressure for operating the clutch, determine a position for the piston in the actuator device from the pressure signal, and move the piston to the position to operate the clutch at the selected fluid pressure.

Abstract: A respiratory disease analytics system provides respiratory disease risk reports to a patient, provider, or third-party entity describing a patient's risk of experiencing a medication usage event given data in a geographic region. Regional data, including air pollutant conditions, weather conditions, demographic information, built environment factors, and regional health conditions for a geographic region are accessed from other sources and assigned based on event data recorded during a medicament usage event, as collected by sensors associated with the patient's medicament device/s. The regional data is assigned to medicament usage events occurring within a period of time. The assigned regional data is analyzed to determine an expected number of medication usage events for the geographic region occurring over the period of time.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a direct-lit backlight unit. The backlight unit may include an array of light-emitting diodes (LEDs) on a printed circuit board. The display may have a notch to accommodate an input-output component. Reflective layers may be included in the notch. The backlight may include a color conversion layer with a property that varies as a function of position. The light-emitting diodes may be covered by a slab of encapsulant with recesses in an upper surface.

Abstract: Apparatus, for use at a valve of a heart of a subject, includes a first catheter, a second catheter, and a translation element. The translation element is connected to, and operatively joins, the distal ends of the first catheter and the second catheter. The translation element is operable to translate the distal ends laterally with respect to each other to transition the apparatus between (i) a first state in which the distal ends are held next to each other for transluminal advancement to the heart, and (ii) a second state in which the distal ends are spaced apart from each other for positioning at a first location on the annulus and a second location on the annulus, respectively. The apparatus is configured to, while in the second state, from the distal ends, anchor a first tissue anchor at the first location, and a second tissue anchor at the second location.

Abstract: An in-situ fenestration device. The device includes a sheath including a proximal end and a distal end. The device also includes an expandable cone including a proximal end, a distal end, and a body extending between the proximal end and the distal end. The expandable cone includes a heating element. The expandable cone is configured to expand from a crimped state within the sheath into an expanded state extending from the distal end of the sheath. The heating element of the expandable cone is configured to be energized with an energy source to form a fenestration in a graft material at a fenestration site of a stent graft.

Abstract: The present application is directed to a polymer comprising a moiety of formula: wherein X, Y, i, j, s, and k are as described herein and salts thereof and to a process of preparing such a polymer.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a direct-lit backlight unit. The backlight unit may include an array of light-emitting diodes (LEDs) on a printed circuit board. The display may have a notch to accommodate an input-output component. Reflective layers may be included in the notch. The backlight may include a color conversion layer with a property that varies as a function of position. The light-emitting diodes may be covered by a slab of encapsulant with recesses in an upper surface.

Abstract: A wound closure device includes multiple base elements arranged in a repeating pattern and a first anchor extending from a first side of each base element of the multiple base elements in a first direction for securing itself to a first layer of tissue along a wound within a body. The wound closure device further includes a second anchor extending from a second side of each base element of the multiple base elements in a second direction that is opposite to the first direction for securing itself within a second layer of tissue along the wound, such that the wound closure device is configured to hold the first and second layers of tissue against each other to close the wound.

Abstract: An exemplary embodiment providing one or more improvements includes apparatus and methods for sensing electrical activity in tissue of a person in a manner which is substantially limits or eliminates interference from noise in a surrounding environment.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a direct-lit backlight unit. The backlight unit may include an array of light-emitting diodes (LEDs) on a printed circuit board. The display may have a notch to accommodate an input-output component. Reflective layers may be included in the notch. The backlight may include a color conversion layer with a property that varies as a function of position. The light-emitting diodes may be covered by a slab of encapsulant with recesses in an upper surface.

Abstract: Features for a restraint to facilitate delivery and deployment of an implantable cardiac device are described. The restraint may include a series of circumferential engagements for securing inwardly corresponding portions of the implant. The restraint may be located inside the implant and provide a radially inward force on the implant. The restraint may include a center shaft having a series of grooves configured to cooperate with corresponding splines of the implant. Distal or proximal advance of the restraint disengages the restraint from the implant. The implant may include a tubular frame configured to contract and be secured by the restraint in a contracted configuration and to expand upon disengagement from the restraint. The restraint may provide for a smaller overall cross-sectional profile of a transcatheter delivery system, for instance by negating the need for a distal delivery sheath.

Abstract: Features for a restraint, such as a cap, are described. The restraint secures a cardiac device in a collapsed, delivery configuration for transcatheter delivery to a heart. The restraint may have a tubular sidewall extending from a proximal end to a distal end, a proximal opening defined by the sidewall at the proximal end and a channel defined by the sidewall and extending distally from the proximal opening. The restraint is configured to receive the implant in the collapsed configuration through the proximal opening to radially restrain the implant within the channel. The restraint eliminates the need for a surrounding sheath, reducing the delivery profile and size of the overall delivery system, among other advantages. The restraint may have an atraumatic leading edge to reduce the risk of injury to the patient.

Abstract: A biopsy device configured to engage target tissue within a patient and to remove a sample of the target tissue from the patient. The biopsy device comprises an elongate catheter configured to be inserted into a patient. A sampling component is disposed at the distal end of the catheter to sample the target tissue.

Abstract: Systems, devices and methods related to various heart valve implants and for delivery of those implants are described. The implants may be used to re-size a native valve annulus or to replace a native heart valve. The implants include a re-sizable frame having angled struts. The implant is secured to tissue with anchors that can rotate without axial advancement to engage tissue while drawing the implant closer to the tissue. Collars are used to decrease the angle between struts of a frame to contract the implant. The implants can include a rotatable shaft, such as a threaded shaft, located internally to an axially translatable collar. Rotation of the shaft transmits force to the collar to cause the collar to translate axially, closing the angle of adjacent struts and decreasing the width of the implant and thus of the annulus. The implants can be delivered, secured and contracted via a catheter. The implants are repositionable and retrievable via catheter.

Abstract: An implantable stent includes multiple circumferential segments that surround a bore and are connected in series along a length to form a tubular wall. Multiple adjacent alternating opposite facing crowns arranged along each segment's circumference are bridged by struts. The struts include a series of staggered arcuate edges with limited flats to provide a limited region of maximum width between significantly extended reducing diameter tapers at either end where they transition into the crowns. Connections between adjacent segments are wider and stiffer than the struts and strut-crown transitions in the segments. The crowns include inner and outer radii with off-set centers along a common axis to provide medial crown peaks along the axis that are wider than the narrowed crown shoulders on either side of the axis and from which the tapered struts extend. Material strain and flexure along the stent during lateral bending is distributed mainly within the segments, e.g.