Patents by Inventor Michael J. Marek

Michael J. Marek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Post-labeling stabilization of radiolabeled proteins and peptides
    Publication number: 20040120892
    Abstract: The subject invention relates to the use of ascorbic acid and derivatives thereof in stabilizing radiolabeled proteins and peptides against oxidation loss of radiolabel and autoradiolysis. Ascorbic acid is added after radiolabeling, including any required incubation period, but prior to patient administration.
    Type: Application
    Filed: December 10, 2003
    Publication date: June 24, 2004
    Inventors: Paul O. Zamora, Michael J. Marek
  • Post-labeling stabilization of radiolabeled proteins and peptides
    Patent number: 6685912
    Abstract: The subject invention relates to the use of ascorbic acid and derivatives thereof in stabilizing radiolabeled proteins and peptides against oxidation loss of radiolabel and autoradiolysis. Ascorbic acid is added after radiolabeling, including any required incubation period, but prior to patient administration.
    Type: Grant
    Filed: April 30, 2002
    Date of Patent: February 3, 2004
    Assignee: Rhomed Incorporated
    Inventors: Paul O. Zamora, Michael J. Marek
  • Post-labeling stabilization of radiolabeled proteins and peptides
    Publication number: 20030017108
    Abstract: The subject invention relates to the use of ascorbic acid and derivatives thereof in stabilizing radiolabeled proteins and peptides against oxidation loss of radiolabel and autoradiolysis. Ascorbic acid is added after radiolabeling, including any required incubation period, but prior to patient administration.
    Type: Application
    Filed: April 30, 2002
    Publication date: January 23, 2003
    Applicant: Rhomed Incorporated
    Inventors: Paul O. Zamora, Michael J. Marek
  • Post-labeling stabilization of radiolabeled proteins and peptides
    Publication number: 20010055563
    Abstract: The subject invention relates to the use of ascorbic acid and derivatives thereof in stabilizing radiolabeled proteins and peptides against oxidation loss of radiolabel and autoradiolysis. Ascorbic acid is added after radiolabeling, including any required incubation period, but prior to patient administration.
    Type: Application
    Filed: July 6, 2001
    Publication date: December 27, 2001
    Applicant: Rhomed Incorporated
    Inventors: Paul O. Zamora, Michael J. Marek
  • Post labeling stabilization of radiolabeled proteins and peptides
    Patent number: 6261536
    Abstract: The subject invention relates to the use of ascorbic acid and derivatives thereof in stabilizing radiolabeled proteins and peptides against oxidation loss of radiolabel and autoradiolysis. Ascorbic acid is added after radiolabeling, including any required incubation period, but prior to patient administration.
    Type: Grant
    Filed: September 9, 1999
    Date of Patent: July 17, 2001
    Assignee: RhoMed Incorporated
    Inventors: Paul O. Zamora, Michael J. Marek
  • Peptide radiopharmaceutical applications
    Patent number: 5985240
    Abstract: The invention relates to radiotherapy with somatostatin-derived peptides labeled with medically useful metal ions. The invention in particular provides for methods and reagents for labeling somatostatin-derived peptides with perrhenate, in which a solution including somatostatin-derived peptide analogue containing at least one disulfide bond is provided, the solution is reacted with stannous ions and with a radioisotope, wherein the stannous ions are sufficient to substantially reduce the disulfide bonds of the peptide and the radioisotope, and the radiolabeled somatostatin-derived peptide analogue recovered. Also provided are methods for regional administration of radiolabeled somatostatin-derived peptides, methods for enhanced regional retention of radiolabeled somatostatin-derived peptides, methods for treatment of arthritis using radiolabeled somatostatin derived peptides, and methods for stabilizing radiolabeled somatostatin derived peptides.
    Type: Grant
    Filed: May 21, 1996
    Date of Patent: November 16, 1999
    Assignee: RhoMed Incorporated
    Inventors: Paul O. Zamora, Buck A. Rhodes, Michael J. Marek
  • Method for lyophilizing ifosfamide
    Patent number: 5972912
    Abstract: A method of lyophilizing an oxazaphosphorin and a preparation produced thereby including dissolving an oxazaphosphorin in water, adding an amino acid to a molar ratio of between 1 to 10 amino acid to 1 oxazaphosphorin to produce a mixture and lyophilizing said mixture to remove said water, is disclosed.
    Type: Grant
    Filed: December 17, 1998
    Date of Patent: October 26, 1999
    Assignee: S.P. Pharmaceuticals
    Inventors: Michael J. Marek, Garnet G. Smith, Thomas R. Kovalcik