Patents by Inventor Michael J. Martinelli

Michael J. Martinelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED PICTET-SPENGLER REACTION AND PRODUCTS PREPARED THEREFROM
    Publication number: 20090312548
    Abstract: A method of introducing a second stereogenic center into a tetrahydro-?-carboline have two stereogenic centers using a modified Pictet-Spengler reaction is disclosed. The method provides a desired cis- or trans-isomer in high yield and purity, and in short processes times.
    Type: Application
    Filed: June 18, 2009
    Publication date: December 17, 2009
    Inventors: Mark W. Orme, Michael J. Martinelli, Christopher W. Doecke, Joseph M. Pawlak, Erik C. Chelius
  • Modified Pictet-Spengler reaction and products prepared therefrom
    Patent number: 7550479
    Abstract: A method of introducing a second stereogenic center into a tetrahydro-?-carboline have two stereogenic centers using a modified Pictet-Spengler reaction is disclosed. The method provides a desired cis- or trans-isomer in high yield and purity, and in short processes times.
    Type: Grant
    Filed: July 14, 2003
    Date of Patent: June 23, 2009
    Assignee: Lilly ICOS LLC
    Inventors: Mark W. Orme, Michael J. Martinelli, Christopher W. Doecke, Joseph M. Pawlak, Erik C. Chelius
  • Cryptophycin compounds
    Patent number: 6680311
    Abstract: The present invention provides cryptophycin compounds of Formula I that are useful in the treatment of neoplasms.
    Type: Grant
    Filed: February 25, 1998
    Date of Patent: January 20, 2004
    Assignees: Eli Lilly and Company, Wayne State University, University of Hawaii
    Inventors: Rima S Al-Awar, William J Ehlhardt, Subbaraju V Gottumukkala, Michael J Martinelli, Eric D Moher, Richard E Moore, John E Munroe, Bryan H Norman, Vinod F Patel, James E Ray, Chuan Shih, John E Toth, Venkatraghavan Vasudevan
  • Selective sulphonation of the primary alcohol of a diol containing both primary and secondary alcohols
    Patent number: 6194586
    Abstract: This invention discloses an efficient process for selectively sulfonating the primary alcohol of a diol containing both primary and secondary alcohols.
    Type: Grant
    Filed: February 25, 1998
    Date of Patent: February 27, 2001
    Assignees: Eli Lilly and Company, Wayne State University, University of Hawaii
    Inventors: Michael J. Martinelli, Eric D Moher
  • Process and novel intermediates
    Patent number: 6020512
    Abstract: Novel processes and intermediates useful in the preparation of Cryptophycin compounds are disclosed.
    Type: Grant
    Filed: February 25, 1998
    Date of Patent: February 1, 2000
    Assignees: Eli Lilly and Company, Wayne State University, University of Hawaii
    Inventors: Michael J. Martinelli, Eric D Moher, Naresh K Nayyar, Joseph M Pawlak, David W Hoard, Vien V Khau, John E Toth, David L Varie
  • Indazolecarboxamides
    Patent number: 5798367
    Abstract: Indazolecarboxamides are used as antagonists and partial agonists for the serotonin receptor 5-HT.sub.4 and provide therapeutic methods for treatment of disorders caused by or affected by dysfunction of the 5-HT.sub.4 receptor.
    Type: Grant
    Filed: January 10, 1997
    Date of Patent: August 25, 1998
    Assignee: Eli Lilly and Company
    Inventors: John T. Catlow, Marlene L. Cohen, Michael J. Martinelli, John M. Schaus, Steven Swanson, Dennis C. Thompson, Thomas M. Wilson
  • 6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenz?CD!indoles
    Patent number: 5783590
    Abstract: 6-Heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz?cd!indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: June 20, 1994
    Date of Patent: July 21, 1998
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, Michael E. Flaugh, David E. Lawhorn, Michael J. Martinelli, Charles J. Paget, Jr., John M. Schaus
  • Excitatory amino acid receptor antagonists
    Patent number: 5675008
    Abstract: This invention provides novel decahydroisoquinoline compounds which are useful as excitatory amino acid receptor antagonists and in the treatment of neurological disorders. This invention also provides synthetic methods for preparing decahydroisoquinolines, as well as, novel intermediates in the synthesis thereof.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: October 7, 1997
    Assignee: Eli Lilly and Company
    Inventors: Carl F. Bertsch, Bret Huff, Michael J. Martinelli, Paul L. Ornstein
  • 6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenzn [cd] indoles
    Patent number: 5665744
    Abstract: 6-Thiadiazole-4-1-amino-1,2,2a,3,4,5-hexahydrobenz[c-d]indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: September 9, 1997
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, David E. Lawhorn, Michael J. Martinelli, Charles J. Paget, Jr., John M. Schaus
  • 6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenz[cd]indoles
    Patent number: 5656653
    Abstract: 6-Heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: August 12, 1997
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, David E. Lawhorn, Michael J. Martinelli, Charles J. Paget, Jr., John M. Schaus
  • 6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenz[cd]indoles
    Patent number: 5654324
    Abstract: 6-Heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz-[cd]indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: August 5, 1997
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, David E. Lawhorn, Michael J. Martinelli, Charles J. Paget, Jr., John M. Schaus
  • Indazolecarboxamides
    Patent number: 5654320
    Abstract: Indazolecarboxamides are used as antagonists and partial agonists for the serotonin receptor 5-HT.sub.4 and provide therapeutic methods for treatment of disorders caused by or affected by dysfunction of the 5-HT.sub.4 receptor.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 5, 1997
    Assignee: Eli Lilly and Company
    Inventors: John T. Catlow, Michael J. Martinelli, John M. Schaus, Steven Swanson, Dennis C. Thompson
  • 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[CD]indoles
    Patent number: 5648356
    Abstract: 6-Heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 15, 1997
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, David E. Lawhorn, Michael J. Martinelli, Charles J. Paget, Jr., John M. Schaus
  • Process for preparing isoquinoline compounds
    Patent number: 5648492
    Abstract: This invention provides novel decahydroisoquinoline compounds which are useful as excitatory amino acid receptor antagonists and in the treatment of neurological disorders. This invention also provides synthetic methods for preparing decahydroisoquinolines, as well as, novel intermediates in the synthesis thereof.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: July 15, 1997
    Assignee: Eli Lilly and Company
    Inventors: M. Brian Arnold, Carl F. Bertsch, Marvin M. Hansen, Allen R. Harkness, Bret Huff, Michael J. Martinelli, Paul L. Ornstein
  • 6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenz[CD]indoles
    Patent number: 5643910
    Abstract: 6-Heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz-[cd]indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 1, 1997
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, David E. Lawhorn, Michael J. Martinelli, Charles J. Paget, Jr., John M. Schaus
  • 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz [CD]indoles
    Patent number: 5643934
    Abstract: 6-Heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 1, 1997
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, David E. Lawhorn, Michael J. Martinelli, Charles J. Paget, Jr., John M. Schaus
  • 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles
    Patent number: 5641794
    Abstract: 6-Heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz-[cd]indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: June 24, 1997
    Assignee: Eli Lilly Company
    Inventors: Richard N. Booher, David E. Lawhorn, Michael J. Martinelli, Charles J. Paget, Jr., John M. Schaus
  • Process of preparing isoquinoline compounds
    Patent number: 5637712
    Abstract: This invention provides novel decahydroisoquinoline compounds which are useful as excitatory amino acid receptor antagonists and in the treatment of neurological disorders. This invention also provides synthetic methods for preparing decahydroisoquinolines, as well as, novel intermediates in the synthesis thereof.
    Type: Grant
    Filed: November 21, 1994
    Date of Patent: June 10, 1997
    Assignee: Eli Lilly and Company
    Inventors: Carl F. Bertsch, Bret Huff, Michael J. Martinelli
  • 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd] indoles
    Patent number: 5633273
    Abstract: 6-Heterocyclic-4-amino-l,2,2a,3,4,5-hexahydrobenz-[cd]indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: May 27, 1997
    Assignee: Eli Lilly and Company
    Inventors: Richard N. Booher, David E. Lawhorn, Michael J. Martinelli, Charles J. Paget, Jr., John M. Schaus
  • 6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenz [CD] indoles
    Patent number: 5627199
    Abstract: 6-Heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles are provided which are useful in modifying the function of serotonin in mammals.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: May 6, 1997
    Assignee: ELi Lilly and Company
    Inventors: Richard N. Booher, David E. Lawhorn, Michael J. Martinelli, Charles J. Paget, Jr., John M. Schaus