Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

Abstract: Devices, systems, and methods for making and using highly sustainable circuit assemblies are disclosed herein. In various aspects, the highly sustainable circuit assembly includes a substrate layer; and a pattern of contact points supported by the substrate layer. The pattern of contact points can be configured to correspond to at least one terminal of an electrical component. The pattern of contact points can include a deformable conductive material. The deformable conductive material can be a non-hazardous, readily reclaimable, readily recyclable material.

Abstract: A frame system for a vehicle including a high-voltage component that includes a pair of spaced apart primary rails that extend from a front of the vehicle toward a rear of the vehicle and a pair of longitudinally extending sills. An impact support rail extends outward from each of the primary rails, and connects each respective primary rail to one of the sills. A cross-member extends outward from each of the primary rails, and connects each respective primary rail to one of the sills, and a laterally extending frame support member extends between the sills at a location between the impact support rails and the cross-members. A pocket is collectively formed between each primary rail, the respective impact support rail, the respective sill, the respective cross-member, and the laterally extending frame support member, and the pocket is configured for receipt and protection of the high-voltage component.

Abstract: A frame system for a vehicle including a high-voltage component that includes a pair of spaced apart primary rails that extend from a front of the vehicle toward a rear of the vehicle and a pair of longitudinally extending sills. An impact support rail extends outward from each of the primary rails, and connects each respective primary rail to one of the sills. A cross-member extends outward from each of the primary rails, and connects each respective primary rail to one of the sills, and a laterally extending frame support member extends between the sills at a location between the impact support rails and the cross-members. A pocket is collectively formed between each primary rail, the respective impact support rail, the respective sill, the respective cross-member, and the laterally extending frame support member, and the pocket is configured for receipt and protection of the high-voltage component.

Abstract: A mount to couple a transmission to a vehicle body includes a first body with at least one first body connector, and a second body with at least one coupler connected to the first body and which includes a damping material arranged to damp vibrations between the first body and second body. A retainer is carried by the first body and has a portion that overlaps part of the second body to prevent separation of the second body from the first body in a first state of the retainer. The retainer is broken or removed from the first body in a second state to permit separation of the second body from the first body, and the retainer breaks or is removed from the first body under a force less than the force needed to break or remove the at least one first body connector from the vehicle body.

Abstract: A mount to couple a transmission to a vehicle body includes a first body with at least one first body connector, and a second body with at least one coupler connected to the first body and which includes a damping material arranged to damp vibrations between the first body and second body. A retainer is carried by the first body and has a portion that overlaps part of the second body to prevent separation of the second body from the first body in a first state of the retainer. The retainer is broken or removed from the first body in a second state to permit separation of the second body from the first body, and the retainer breaks or is removed from the first body under a force less than the force needed to break or remove the at least one first body connector from the vehicle body.

Abstract: A galvanic cell and methods of using the galvanic cell is described for the recovery of uranium from used nuclear fuel according to an electrofluorination process. The galvanic cell requires no input energy and can utilize relatively benign gaseous fluorinating agents. Uranium can be recovered from used nuclear fuel in the form of gaseous uranium compound such as uranium hexafluoride, which can then be converted to metallic uranium or UO2 and processed according to known methodology to form a useful product, e.g., fuel pellets for use in a commercial energy production system.

Abstract: A galvanic cell and methods of using the galvanic cell is described for the recovery of uranium from used nuclear fuel according to an electrofluorination process. The galvanic cell requires no input energy and can utilize relatively benign gaseous fluorinating agents. Uranium can be recovered from used nuclear fuel in the form of gaseous uranium compound such as uranium hexafluoride, which can then be converted to metallic uranium or UO2 and processed according to known methodology to form a useful product, e.g., fuel pellets for use in a commercial energy production system.

Abstract: A galvanic cell and methods of using the galvanic cell is described for the recovery of uranium from used nuclear fuel according to an electrofluorination process. The galvanic cell requires no input energy and can utilize relatively benign gaseous fluorinating agents. Uranium can be recovered from used nuclear fuel in the form of gaseous uranium compound such as uranium hexafluoride, which can then be converted to metallic uranium or UO2 and processed according to known methodology to form a useful product, e.g., fuel pellets for use in a commercial energy production system.

Abstract: A galvanic cell and methods of using the galvanic cell is described for the recovery of uranium from used nuclear fuel according to an electrofluorination process. The galvanic cell requires no input energy and can utilize relatively benign gaseous fluorinating agents. Uranium can be recovered from used nuclear fuel in the form of gaseous uranium compound such as uranium hexafluoride, which can then be converted to metallic uranium or UO2 and processed according to known methodology to form a useful product, e.g., fuel pellets for use in a commercial energy production system.

Abstract: A concrete floor system used in a building structure and a method of making floor components used with the floor system. The concrete floor system, if installed on grade, provides for expansion and contraction due to expansive soils and eliminates cracks, which heretofore occurred in poured concrete slab floors. The concrete floor system includes a plurality of parallel concrete beams. The beams can be made up of hollow concrete blocks for reduced weight and receiving a tension cable therethrough. Also, the beams can be either solid pre-cast beams, solid pre-cast, pre-tension beams or solid pre-cast, post-tension beams. Opposite ends of the cable are held on end plates inside recessed ends of each hollow beam. The ends of the beams are adapted for mounting next to the inside of the sides of a building foundation wall. The beams can be in a range of 5 to 20 feet and greater in length depending on the dimensions of the concrete floor.

Abstract: A foundation haunch assembly used for attachment to a foundation wall and a method of making the haunch assembly using a concrete block machine. The haunch assembly includes a concrete haunch having an upper portion, a center portion and a lower portion. The upper portion of the haunch includes a flat top surface adapted for receiving a portion of a pre-cast concrete slab, stairs, stoops, poured in place concrete slab or other building structure thereon. Also, the upper portion includes an internal horizontal metal support rod along the length thereof. One end of the support rod is threaded to one end of a threaded coupling. The foundation haunch assembly also includes a variable length foundation bolt with a threaded end threaded into an opposite end of the threaded coupling. The foundation bolt is adapted for receipt through a hole in a portion of a vertical foundation wall. An opposite threaded end of the foundation bolt is attached to a nut.

Abstract: A plurality of solid core concrete blocks used in forming a retaining wall. The retaining wall can be used in building construction, road construction, landscaping, hillside erosion control, gardens, and like applications. Also, the retaining wall can be a straight wall, an angled wall or a curved wall depending on the application. Each of the blocks includes a vertical front face and rear face, a horizontal top and bottom and a vertical first side and second side. The first side includes a first ear and two sides of an angular first notch next to the first ear. One side of the first notch is parallel to a length of the front and rear faces and forms a side of the first ear. A second side of the first notch is disposed inwardly into the block and at an angle of 10 to 45 degrees from a horizontal line perpendicular to a length of the front and rear faces.

Abstract: A tire chain device includes a backing plate mountable between the wheel and brake drum of a vehicle and having a continuous circular anchor rod as part thereof. A plurality of cross chains are connected at one end to a main chain member extending around the outer face of the vehicle tire with the opposite or inner ends of the cross chains having a hook thereon adapted to be releasably anchored to the circular rod on the backing plate. The main chain includes a tensioning hook adapted to tighten the main chain to draw the cross chains tightly across the periphery of the tire.