Patents by Inventor Michael J. Mastrangelo

Michael J. Mastrangelo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of inducing an immune response using vaccinia virus recombinants
    Publication number: 20030086906
    Abstract: A method of inducing expression of immune active cytokines in tumors in situ is provided wherein a vaccinia virus vector capable of inducing expression of a selected cytokine is generated and injected into a tumor so that cells of the tumor express the selected cytokine. A method of enhancing immunity in a host by administration of a vaccinia virus vector is also provided. Methods of treating cancer by administration of these vaccinia virus vectors are also provided.
    Type: Application
    Filed: November 4, 2002
    Publication date: May 8, 2003
    Inventors: Michael J. Mastrangelo, Edmund C. Lattime, David Berd, Laurence C. Eisenlohr
  • Method of inducing an immune response using vaccinia virus recombinants
    Patent number: 6475999
    Abstract: A method of inducing expression of immune active cytokines in tumors in situ is provided wherein a vaccinia virus vector capable of inducing expression of a selected cytokine is generated and injected into a tumor so that cells of the tumor express the selected cytokine. A method of enhancing immunity in a host by administration of a vaccinia virus vector is also provided. Methods of treating cancer by administration of these vaccinia virus vectors are also provided.
    Type: Grant
    Filed: June 19, 2000
    Date of Patent: November 5, 2002
    Assignee: Thomas Jefferson University
    Inventors: Michael J. Mastrangelo, Edmund C. Lattime, David Berd, Laurence C. Eisenlohr
  • Method of treating bladder cancer with wild type vaccinia virus
    Patent number: 6177076
    Abstract: Methods of treating bladder cancer in a patient by administration of wildtype vaccinia virus are provided.
    Type: Grant
    Filed: December 7, 1998
    Date of Patent: January 23, 2001
    Assignee: Thomas Jefferson University
    Inventors: Edmund C. Lattime, Michael J. Mastrangelo
  • Method of inducing an immune response using vaccinia virus recombinants encoding GM-CSF
    Patent number: 6093700
    Abstract: A method of inducing expression of immune active cytokines in tumors in situ is provided wherein a vaccinia virus vector capable of inducing expression of a selected cytokine is generated and injected into a tumor so that cells of the tumor express the selected cytokine. A method of enhancing immunity in a host by administration of a vaccinia virus vector is also provided. Methods of treating cancer by administration of these vaccinia virus vectors are also provided.
    Type: Grant
    Filed: February 20, 1997
    Date of Patent: July 25, 2000
    Assignee: Thomas Jefferson University
    Inventors: Michael J. Mastrangelo, Edmund C. Lattime, David Berd, Laurence C. Eisenlohr