Abstract: A method by which a freeze-drying process may be developed from a single freeze-drying experiment. The method uses in-process manometric temperature measurement (MTM) data to optimize the primary drying conditions. Manometric temperature measurement is a procedure by which the product temperature at the sublimation interface and the resistance of the previously dried product to vapor flow may be determined. The inventive method can be used in an inventive freeze-drying system. The system comprises a freeze-dryer, a measurement system including hardware and software necessary for generation of MTM data and a control system including hardware and software for interpretation of the generated MTM data and control of the freeze-dryer. The measurement system and control system may be combined into a single device.

Abstract: Parenteral pharmaceutical formulations of human growth hormone, which are stabilized against aggregation, comprising biosynthetic human growth hormone, glycine, and mannitol. Methods of reducing aggregation of human growth hormone in parenteral formulations are also provided.

Abstract: Ceftazidime pentahydrate is formulated with a pharmaceutically acceptable base and amorphous lactose to provide stabilized pharmaceutically acceptable formulations.