Patents by Inventor Michael J. Yost
Michael J. Yost has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10092624Abstract: Provided are peptides that can inhibit collagen synthesis, processing and/or secretion. In some aspects, the therapeutic peptides may be used to treat a cancer such as, e.g., a pancreatic cancer or a glioblastoma.Type: GrantFiled: April 22, 2016Date of Patent: October 9, 2018Assignees: MUSC Foundation for Research Development, University of South CarolinaInventors: Robert G. Gourdie, Edie C. Goldsmith, L. Jane Jourdan, Joshua Matthew Rhett, Michael J. Yost
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Patent number: 9764515Abstract: Disclosed are systems, compositions, and methods for three-dimensional (3D) printing. An example system includes a plurality dispensers configured to deposit materials from their tips and a printing surface for receiving the materials. The system includes a position sensing detector configured to detect positions of the tips of the dispensers and the location and dimensions of the printing surface. The system includes a robotic positioning device configured to drive the dispensers. The system also includes a control unit configured to receive and map in a 3D space the positions of the tips of the dispensers and the position and dimensions of the printing surface. The control unit is further configured to control the robotic positioning device to drive the dispensers relative to the printing surface in the 3D space, and to independently deposit materials on the printing surface, or on material deposited on the printing surface.Type: GrantFiled: May 1, 2015Date of Patent: September 19, 2017Assignees: MUSC Foundation for Research Development, Izumi International, Inc., Clemson UniversityInventors: Michael J. Yost, Thomas Trusk, Ying Mei, Michael Chappell, Walter Boylan
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Publication number: 20160287663Abstract: Provided are peptides that can inhibit collagen synthesis, processing and/or secretion from scar forming cells or fibroblasts. Also provided are methods for using the peptides to produce an anti-fibrotic, anti-scarring, anti-inflammatory, and/or pro-regenerative effect, e.g., on an injured or diseased tissue.Type: ApplicationFiled: April 22, 2016Publication date: October 6, 2016Applicants: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT, UNIVERSITY OF SOUTH CAROLINAInventors: Robert G. GOURDIE, Edie C. GOLDSMITH, L. Jane JOURDAN, Joshua Matthew RHETT, Michael J. YOST
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Patent number: 9345744Abstract: Provided are peptides that can inhibit collagen synthesis, processing and/or secretion from scar forming cells or fibroblasts. Also provided are methods for using the peptides to produce an anti-fibrotic, anti-scarring, anti-inflammatory, and/or pro-regenerative effect, e.g., on an injured or diseased tissue.Type: GrantFiled: April 25, 2013Date of Patent: May 24, 2016Assignees: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT, UNIVERSITY OF SOUTH CAROLINAInventors: Robert G. Gourdie, Edie C. Goldsmith, L. Jane Jourdan, Joshua Matthew Rhett, Michael J. Yost
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Publication number: 20150375453Abstract: Disclosed are systems, compositions, and methods for three-dimensional (3D) printing. An example system includes a plurality dispensers configured to deposit materials from their tips and a printing surface for receiving the materials. The system includes a position sensing detector configured to detect positions of the tips of the dispensers and the location and dimensions of the printing surface. The system includes a robotic positioning device configured to drive the dispensers. The system also includes a control unit configured to receive and map in a 3D space the positions of the tips of the dispensers and the position and dimensions of the printing surface. The control unit is further configured to control the robotic positioning device to drive the dispensers relative to the printing surface in the 3D space, and to independently deposit materials on the printing surface, or on material deposited on the printing surface.Type: ApplicationFiled: May 1, 2015Publication date: December 31, 2015Inventors: Michael J. Yost, Thomas Trusk, Ying Mei, Michael Chappell, Walter Boylan
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Publication number: 20150174196Abstract: Provided are peptides that can inhibit collagen synthesis, processing and/or secretion from scar forming cells or fibroblasts. Also provided are methods for using the peptides to produce an anti-fibrotic, anti-scarring, anti-inflammatory, and/or pro-regenerative effect, e.g., on an injured or diseased tissue.Type: ApplicationFiled: April 25, 2013Publication date: June 25, 2015Applicants: UNIVERSITY OF SOUTH CAROLINA, MUSC FOUNDATION FOR RESEARCH DEVELOPMENTInventors: Robert G. Gourdie, Edie C. Goldsmith, L. Jane Jourdan, Joshua Matthew Rhett, Michael J. Yost
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Patent number: 7878786Abstract: An apparatus for producing a tubular tissue scaffold having aligned biopolymer fibrils including a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device.Type: GrantFiled: February 25, 2008Date of Patent: February 1, 2011Assignee: University of South CarolinaInventors: Michael J. Yost, C. Michael Gore, Louis Terracio, Richard L. Goodwin, Edie C. Goldsmith
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Patent number: 7754247Abstract: The present invention relates to a resuscitation fluid which includes an ionic salt at a concentration above about 0.9%, at least one soluble protein, at least one intermediate energy substrate, and optionally an agent to mitigate intracellular acidosis. Methods of making and using the fluid are also described.Type: GrantFiled: May 29, 2007Date of Patent: July 13, 2010Inventors: Stephan Fann, Michael J. Yost
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Publication number: 20100166885Abstract: The present invention relates to a resuscitation fluid which includes an ionic salt at a concentration above about 0.9%, at least one soluble protein, at least one intermediate energy substrate, and optionally an agent to mitigate intracellular acidosis. Methods of making and using the fluid are also described.Type: ApplicationFiled: March 12, 2010Publication date: July 1, 2010Applicant: University of South CarolinaInventors: Stephan Fann, Michael J. Yost
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Patent number: 7727441Abstract: A tubular tissue scaffold is described which comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube where the pitch of the helical pattern changes with the radial position in the tube wall. The scaffold is capable of directing the morphological pattern of attached and growing cells to form a helical pattern around the tube walls. Additionally, an apparatus for producing such a tubular tissue scaffold is disclosed, the apparatus comprising a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device. A method for producing the tubular tissue scaffolds is also disclosed.Type: GrantFiled: February 25, 2008Date of Patent: June 1, 2010Inventors: Michael J. Yost, C. Michael Gore, Louis Terracio, Richard L. Goodwin, Edie C. Goldsmith
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Publication number: 20080299224Abstract: The present invention relates to a resuscitation fluid which includes an ionic salt at a concentration above about 0.9%, at least one soluble protein, at least one intermediate energy substrate, and optionally an agent to mitigate intracellular acidosis. Methods of making and using the fluid are also described.Type: ApplicationFiled: May 29, 2007Publication date: December 4, 2008Applicant: University of South Carolina Research FoundationInventors: Stephan Fann, Michael J. Yost
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Publication number: 20080217820Abstract: A tubular tissue scaffold is described which comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube where the pitch of the helical pattern changes with the radial position in the tube wall. The scaffold is capable of directing the morphological pattern of attached and growing cells to form a helical pattern around the tube walls. Additionally, an apparatus for producing such a tubular tissue scaffold is disclosed, the apparatus comprising a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device. A method for producing the tubular tissue scaffolds is also disclosed.Type: ApplicationFiled: February 25, 2008Publication date: September 11, 2008Applicant: University of South CarolinaInventors: Michael J. Yost, C. Michael Gore, Louis Terracio, Richard L. Goodwin, Edie C. Goldsmith
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Publication number: 20080220506Abstract: A tubular tissue scaffold is described which comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube where the pitch of the helical pattern changes with the radial position in the tube wall. The scaffold is capable of directing the morphological pattern of attached and growing cells to form a helical pattern around the tube walls. Additionally, an apparatus for producing such a tubular tissue scaffold is disclosed, the apparatus comprising a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device. A method for producing the tubular tissue scaffolds is also disclosed.Type: ApplicationFiled: February 25, 2008Publication date: September 11, 2008Applicant: University of South CarolinaInventors: Michael J. Yost, C. Michael Gore, Louis Terracio, Richard L. Goodwin, Edie C. Goldsmith
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Publication number: 20080147199Abstract: A tubular tissue scaffold is described which comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube where the pitch of the helical pattern changes with the radial position in the tube wall. The scaffold is capable of directing the morphological pattern of attached and growing cells to form a helical pattern around the tube walls. Additionally, an apparatus for producing such a tubular tissue scaffold is disclosed, the apparatus comprising a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device. A method for producing the tubular tissue scaffolds is also disclosed.Type: ApplicationFiled: February 25, 2008Publication date: June 19, 2008Applicant: University of South CarolinaInventors: Michael J. Yost, C. Michael Gore, Louis Terracio, Richard L. Goodwin, Edie C. Goldsmith
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Patent number: 7338517Abstract: A tubular tissue scaffold is described which comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube where the pitch of the helical pattern changes with the radial position in the tube wall. The scaffold is capable of directing the morphological pattern of attached and growing cells to form a helical pattern around the tube walls. Additionally, an apparatus for producing such a tubular tissue scaffold is disclosed, the apparatus comprising a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device. A method for producing the tubular tissue scaffolds is also disclosed.Type: GrantFiled: June 4, 2004Date of Patent: March 4, 2008Assignee: University of South CarolinaInventors: Michael J. Yost, C. Michael Gore, Louis Terracio, Richard L. Goodwin, Edie C. Goldsmith