Abstract: An example implantable medical device includes a stimulating lead includes receive one or more signals indicative of one or more physiologic parameters; deliver electrical therapy to stimulate a muscle wrapped around a heart via one or more electrodes of a stimulating lead; and adjust an amount of the electrical therapy delivered, via the stimulating electrodes, based on the one or more physiologic parameters.

Abstract: A simulation application simulates a fluid flow. The simulation application divides a fluid into coarse volumetric elements (voxels) at a first resolution, and simulates the fluid flow at the first resolution. The simulation application defines a three-dimensional window that includes a portion of the coarse voxels. The simulation application divides each coarse voxel in the portion of the coarse voxels that lie within the three-dimensional window into a plurality of fine voxels at a second resolution. The simulation application simulates the fluid flow associated with each fine voxel in the plurality of fine voxels at the second resolution based at least in part on the simulation at the coarse resolution.

Abstract: A simulation application models a surface of a fluid in motion. The simulation application selects a mesh point from a plurality of mesh points that is associated with the surface of the fluid. The simulation application retrieves a first texture element from a set of uv texture maps, and attaches a first displacement value to the mesh point based on the first texture element. The simulation application advects the first displacement value over a first duration represented by a first quantity of image frames such that the first displacement value remains attached to the mesh point as the plurality of mesh points moves in response to a motion of the fluid.

Abstract: A simulation application simulates a fluid flow. The simulation application divides a fluid into coarse volumetric elements (voxels) at a first resolution, and simulates the fluid flow at the first resolution. The simulation application defines a three-dimensional window that includes a portion of the coarse voxels. The simulation application divides each coarse voxel in the portion of the coarse voxels that lie within the three-dimensional window into a plurality of fine voxels at a second resolution. The simulation application simulates the fluid flow associated with each fine voxel in the plurality of fine voxels at the second resolution based at least in part on the simulation at the coarse resolution.

Abstract: A simulation application models a surface of a fluid in motion. The simulation application selects a mesh point from a plurality of mesh points that is associated with the surface of the fluid. The simulation application retrieves a first texture element from a set of uv texture maps, and attaches a first displacement value to the mesh point based on the first texture element. The simulation application advects the first displacement value over a first duration represented by a first quantity of image frames such that the first displacement value remains attached to the mesh point as the plurality of mesh points moves in response to a motion of the fluid.

Abstract: Novel processes for the preparation of adenosine compounds and intermediates thereto. The adenosine compounds prepared by the present processes may be useful as cardiovascular agents, more particularly as antihypertensive and anti-ischemic agents, as cardioprotective agents which ameliorate ischemic injury or myocardial infarct size consequent to myocardial ischemia, and as an antilipolytic agents which reduce plasma lipid levels, serum triglyceride levels, and plasma cholesterol levels. The present processes may offer improved yields, purity, ease of preparation and/or isolation of intermediates and final product, and more industrially useful reaction conditions and workability.

Abstract: This invention is directed to methods for stereospecifically preparing [(1-optionally substituted aryl)- or (1-optionally substituted heteroaryl)]-2-substituted ethyl-2-amines, having chirality at the 2-position, and to intermediates to the substituted ethyl-2-amines.

Abstract: Methods for stereoselective substitution in which a (mono or un)-&agr;-substituted unprotected &bgr;-amino ester compound or salt thereof is reacted with an aliphatic electrophile in the presence of a base selected from alkyl lithium compounds, lithium hydride, lithium amide, lithium dialkyl amides and alkali hexamethyldisilylamines.

Abstract: This invention is directed to a process for preparing N6-substituted adenosine derivatives, to intermediates useful therefor and to methods of preparing these intermediates.

Abstract: The invention is directed to improved methods for preparing N6-substituted adenosine derivatives, to intermediates useful therefor and to methods of preparing these intermediates.

Abstract: This invention is directed to methods for the preparation of [1S-[1a,2b,3b,4a(S*)]]-4-[7-[[1-(3-chloro-2-thienyl) methyl]propyl]amino]-3H-imidazo[4,5-b]pyridin-3-yl]-N-ethyl-2,3-dihydroxyc yclopentanecarboxamide, methods for the preparation of intermediates thereto, and to said intermediates themselves.

Abstract: This invention is directed to methods for stereospecifically preparing [(1-optionally substituted aryl)- or (1-optionally substituted heteroaryl)]-2-substituted ethyl-2-amines, having chirality at the 2-position, and to intermediates to the substituted ethyl-2-amines.

Abstract: Organosilicon polymers, including crosslinked polymers and crosslinkable prepolymers, of cyclic polysiloxanes, organic dyes, and, optionally, polyenes. The dyes include those with delocalized Pi electron systems linking electron donor groups and electron acceptor groups, and with at least two carbon-carbon double bond-containing pendant groups attached to at least two different sites from among the indicated delocalized Pi electron systems, donor groups, and acceptor groups. Also disclosed are optical substrates coated with the organosilicon crosslinked polymers exhibiting second order non-linear optical susceptibility.

Abstract: Arylazo and poly(arylazo) dyes having at least one core radical selected from naphthyl or anthracyl and having at least one 2,3-dihydro-1,3-dialkyl perimidine substituent, a guest-host composition comprising a liquid crystal host solvent and the arylazo or poly(arylazo) dichroic dye, and a liquid crystal display comprising the guest-host composition, are disclosed.

Abstract: Arylazo and poly(arylazo) dyes having at least one core radical selected from naphthyl or anthracyl and having at least one 2,3-dihydro-1,3-dialkyl perimidine substituent, a guest-host composition comprising a liquid crystal host solvent and the arylazo or poly(arylazo) dichroic dye, and a liquid crystal display comprising the guest-host composition, are disclosed.

Abstract: Organosilicon polymers, including crosslinked polymers and crosslinkable prepolymers, of cyclic polysiloxanes, organic dyes, and, optionally, polyenes. The dyes include those with delocalized Pi electron systems linking electron donor groups and electron acceptor groups, and with at least two carbon-carbon double bond-containing pendant groups attached to at least two different sites from among the indicated delocalized Pi electron systems, donor groups, and acceptor groups.

Abstract: Organosilicon polymers, including crosslinked polymers and crosslinkable prepolymers, of cyclic polysiloxanes, organic dyes, and, optionally, polyenes. The dyes include those with delocalized Pi electron systems linking electron donor groups and electron acceptor groups, and with at least two carbon-carbon double bond-containing pendant groups attached to at least two different sites from among the indicated delocalized Pi electron systems, donor groups, and acceptor groups.

Abstract: A snap-on unitary, one piece photo-optical item position sensor fabricated as a clothes-pin-like plastic member from a material which is substantially transparent to infra-red radiation obviating lenses. The sensor member is bifurcated at one end to form two parallel leg portions the outboard end of each one of which carries one element of the photo-optical sensing apparatus. The opposite end of the sensor member is rectangularly shaped and slotted on opposite parallel sides forming a polarized receptacle for a mating polarized plug as well as a handle for griping. Compression of the handle portion contacts the slotted end slightly while opening or spreading the two parallel leg portions enabling the sensor to be snapped over an orthogonally disposed item guide or track. Oppositely disposed parallel members on the lower portion of the track automatically position the sensor over the track.