Patents by Inventor Michael Ka Kit Leung
Michael Ka Kit Leung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220336049Abstract: The present disclosure provides systems and methods for determining effects of genetic variants on selection of polyadenylation sites (PAS) during polyadenylation processes. In an aspect, the present disclosure provides a polyadenylation code, a computational model that can predict alternative polyadenylation patterns from transcript sequences. A score can be calculated that describes or corresponds to the strength of a PAS, or the efficiency in which it is recognized by the 3?-end processing machinery. The polyadenylation model may be used, for example, to assess the effects of anti-sense oligonucleotides to alter transcript abundance. As another example, the polyadenylation model may be used to scan the 3?-UTR of a human genome to find potential PAS.Type: ApplicationFiled: March 28, 2022Publication date: October 20, 2022Inventors: Brendan Frey, Michael Ka Kit Leung
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Publication number: 20220331017Abstract: Systems and methods are provided for optical topology detection and illumination. Embodiments provide an integrated system, and methods of operation thereof, where the integrated system includes an illumination system and an optical topology detection system, and where at least a portion of the spectral content of illumination light from the illumination system is within an optical detection bandwidth of the optical topology detection system, and where the operation of the optical topology detection system and the illumination system are interleaved to avoid crosstalk, such that the optical topology detection system detects the optical topology detection light when the illumination system is not emitting illumination light. The system may include, and control the operation of, an optical navigation system. The components of the system may be mounted to a rigid frame to maintain calibration.Type: ApplicationFiled: July 1, 2022Publication date: October 20, 2022Inventors: Victor X.D. YANG, Adrian Linus Dinesh MARIAMPILLAI, Beau Anthony STANDISH, Michael Ka Kit LEUNG
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Patent number: 11376080Abstract: Systems and methods are provided for optical topology detection and illumination. Embodiments provide an integrated system, and methods of operation thereof, where the integrated system includes an illumination system and an optical topology detection system, and where at least a portion of the spectral content of illumination light from the illumination system is within an optical detection bandwidth of the optical topology detection system, and where the operation of the optical topology detection system and the illumination system are interleaved to avoid crosstalk, such that the optical topology detection system detects the optical topology detection light when the illumination system is not emitting illumination light. The system may include, and control the operation of, an optical navigation system. The components of the system may be mounted to a rigid frame to maintain calibration.Type: GrantFiled: February 3, 2020Date of Patent: July 5, 2022Assignee: 7D SURGICAL ULCInventors: Victor X. D. Yang, Adrian Linus Dinesh Mariampillai, Beau Anthony Standish, Michael Ka Kit Leung
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Patent number: 11322225Abstract: The present disclosure provides systems and methods for determining effects of genetic variants on selection of polyadenylation sites (PAS) during polyadenylation processes. In an aspect, the present disclosure provides a polyadenylation code, a computational model that can predict alternative polyadenylation patterns from transcript sequences. A score can be calculated that describes or corresponds to the strength of a PAS, or the efficiency in which it is recognized by the 3?-end processing machinery. The polyadenylation model may be used, for example, to assess the effects of anti-sense oligonucleotides to alter transcript abundance. As another example, the polyadenylation model may be used to scan the 3?-UTR of a human genome to find potential PAS.Type: GrantFiled: January 29, 2021Date of Patent: May 3, 2022Assignee: Deep Genomics IncorporatedInventors: Brendan Frey, Michael Ka Kit Leung
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Publication number: 20210241852Abstract: The present disclosure provides systems and methods for determining effects of genetic variants on selection of polyadenylation sites (PAS) during polyadenylation processes. In an aspect, the present disclosure provides a polyadenylation code, a computational model that can predict alternative polyadenylation patterns from transcript sequences. A score can be calculated that describes or corresponds to the strength of a PAS, or the efficiency in which it is recognized by the 3?-end processing machinery. The polyadenylation model may be used, for example, to assess the effects of anti-sense oligonucleotides to alter transcript abundance. As another example, the polyadenylation model may be used to scan the 3?-UTR of a human genome to find potential PAS.Type: ApplicationFiled: January 29, 2021Publication date: August 5, 2021Inventors: Brendan Frey, Michael Ka Kit Leung
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Publication number: 20210212772Abstract: Systems and methods for surgical guidance and image registration are provided, in which three-dimensional image data associated with an object or patient is registered to topological image data obtained using a surface topology imaging device. The surface topology imaging device may be rigidly attached to an optical position measurement system that also tracks fiducial markers on a movable instrument. The instrument may be registered to the topological image data, such that the topological image data and the movable instrument are registered to the three-dimensional image data. The three-dimensional image data may be CT or MRI data associated with a patient. The system may also co-register images pertaining to a surgical plan with the three-dimensional image data. In another aspect, the surface topology imaging device may be configured to directly track fiducial markers on a movable instrument. The fiducial markers may be tracked according to surface texture.Type: ApplicationFiled: March 31, 2021Publication date: July 15, 2021Inventors: Victor Xiao Dong YANG, Beau Anthony Standish, Adrian Linus Dinesh Mariampillai, Michael Ka Kit Leung
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Patent number: 10980601Abstract: Systems and methods for surgical guidance and image registration are provided, in which three-dimensional image data associated with an object or patient is registered to topological image data obtained using a surface topology imaging device. The surface topology imaging device may be rigidly attached to an optical position measurement system that also tracks fiducial markers on a movable instrument. The instrument may be registered to the topological image data, such that the topological image data and the movable instrument are registered to the three-dimensional image data. The three-dimensional image data may be CT or MRI data associated with a patient. The system may also co-register images pertaining to a surgical plan with the three-dimensional image data. In another aspect, the surface topology imaging device may be configured to directly track fiducial markers on a movable instrument. The fiducial markers may be tracked according to surface texture.Type: GrantFiled: January 30, 2018Date of Patent: April 20, 2021Assignee: RYERSON UNIVERSITYInventors: Victor Xiao Dong Yang, Beau Anthony Standish, Adrian Linus Dinesh Mariampillai, Michael Ka Kit Leung
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Publication number: 20200246080Abstract: Systems and methods are provided for optical topology detection and illumination. Embodiments provide an integrated system, and methods of operation thereof, where the integrated system includes an illumination system and an optical topology detection system, and where at least a portion of the spectral content of illumination light from the illumination system is within an optical detection bandwidth of the optical topology detection system, and where the operation of the optical topology detection system and the illumination system are interleaved to avoid crosstalk, such that the optical topology detection system detects the optical topology detection light when the illumination system is not emitting illumination light. The system may include, and control the operation of, an optical navigation system. The components of the system may be mounted to a rigid frame to maintain calibration.Type: ApplicationFiled: February 3, 2020Publication date: August 6, 2020Inventors: Victor X.D. YANG, Adrian Linus Dinesh MARIAMPILLAI, Beau Anthony STANDISH, Michael Ka Kit LEUNG
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Patent number: 10548672Abstract: Systems and methods are provided for optical topology detection and illumination. Embodiments provide an integrated system, and methods of operation thereof, where the integrated system includes an illumination system and an optical topology detection system, and where at least a portion of the spectral content of illumination light from the illumination system is within an optical detection bandwidth of the optical topology detection system, and where the operation of the optical topology detection system and the illumination system are interleaved to avoid crosstalk, such that the optical topology detection system detects the optical topology detection light when the illumination system is not emitting illumination light. The system may include, and control the operation of, an optical navigation system. The components of the system may be mounted to a rigid frame to maintain calibration.Type: GrantFiled: September 20, 2016Date of Patent: February 4, 2020Assignee: 7D SURGICAL INC.Inventors: Victor X. D. Yang, Adrian Linus Dinesh Mariampillai, Beau Anthony Standish, Michael Ka Kit Leung
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Publication number: 20180153626Abstract: Systems and methods for surgical guidance and image registration are provided, in which three-dimensional image data associated with an object or patient is registered to topological image data obtained using a surface topology imaging device. The surface topology imaging device may be rigidly attached to an optical position measurement system that also tracks fiducial markers on a movable instrument. The instrument may be registered to the topological image data, such that the topological image data and the movable instrument are registered to the three-dimensional image data. The three-dimensional image data may be CT or MRI data associated with a patient. The system may also co-register images pertaining to a surgical plan with the three-dimensional image data. In another aspect, the surface topology imaging device may be configured to directly track fiducial markers on a movable instrument. The fiducial markers may be tracked according to surface texture.Type: ApplicationFiled: January 30, 2018Publication date: June 7, 2018Inventors: Victor Xiao Dong YANG, Beau Anthony Standish, Adrian Linus Dinesh Mariampillai, Michael Ka Kit Leung
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Patent number: 9901409Abstract: Systems and methods for surgical guidance and image registration are provided, in which three-dimensional image data associated with an object or patient is registered to topological image data obtained using a surface topology imaging device. The surface topology imaging device may be rigidly attached to an optical position measurement system that also tracks fiducial markers on a movable instrument. The instrument may be registered to the topological image data, such that the topological image data and the movable instrument are registered to the three-dimensional image data. The three-dimensional image data may be CT or MRI data associated with a patient. The system may also co-register images pertaining to a surgical plan with the three-dimensional image data. In another aspect, the surface topology imaging device may be configured to directly track fiducial markers on a movable instrument. The fiducial markers may be tracked according to surface texture.Type: GrantFiled: November 1, 2016Date of Patent: February 27, 2018Assignee: RYERSON UNIVERSITYInventors: Victor Xiao Dong Yang, Beau Anthony Standish, Adrian Linus Dinesh Mariampillai, Michael Ka Kit Leung
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Publication number: 20170079724Abstract: Systems and methods are provided for optical topology detection and illumination. Embodiments provide an integrated system, and methods of operation thereof, where the integrated system includes an illumination system and an optical topology detection system, and where at least a portion of the spectral content of illumination light from the illumination system is within an optical detection bandwidth of the optical topology detection system, and where the operation of the optical topology detection system and the illumination system are interleaved to avoid crosstalk, such that the optical topology detection system detects the optical topology detection light when the illumination system is not emitting illumination light. The system may include, and control the operation of, an optical navigation system. The components of the system may be mounted to a rigid frame to maintain calibration.Type: ApplicationFiled: September 20, 2016Publication date: March 23, 2017Inventors: Victor X.D. YANG, Adrian Linus Dinesh MARIAMPILLAI, Beau Anthony STANDISH, Michael Ka Kit LEUNG
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Publication number: 20170042622Abstract: Systems and methods for surgical guidance and image registration are provided, in which three-dimensional image data associated with an object or patient is registered to topological image data obtained using a surface topology imaging device. The surface topology imaging device may be rigidly attached to an optical position measurement system that also tracks fiducial markers on a movable instrument. The instrument may be registered to the topological image data, such that the topological image data and the movable instrument are registered to the three-dimensional image data. The three-dimensional image data may be CT or MRI data associated with a patient. The system may also co-register images pertaining to a surgical plan with the three-dimensional image data. In another aspect, the surface topology imaging device may be configured to directly track fiducial markers on a movable instrument. The fiducial markers may be tracked according to surface texture.Type: ApplicationFiled: November 1, 2016Publication date: February 16, 2017Inventors: Victor Xiao Dong YANG, Beau Anthony Standish, Adrian Linus Dinesh Mariampillai, Michael Ka Kit LEUNG
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Patent number: 9513113Abstract: Systems and methods are provided for optical topology detection and illumination. Embodiments provide an integrated system, and methods of operation thereof, where the integrated system includes an illumination system and an optical topology detection system, and where at least a portion of the spectral content of illumination light from the illumination system is within an optical detection bandwidth of the optical topology detection system, and where the operation of the optical topology detection system and the illumination system are interleaved to avoid crosstalk, such that the optical topology detection system detects the optical topology detection light when the illumination system is not emitting illumination light. The system may include, and control the operation of, an optical navigation system. The components of the system may be mounted to a rigid frame to maintain calibration.Type: GrantFiled: October 29, 2013Date of Patent: December 6, 2016Assignee: 7D SURGICAL, INC.Inventors: Victor Yang, Adrian Linus Dinesh Mariampillai, Beau Anthony Standish, Michael Ka Kit Leung
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Patent number: 9510914Abstract: Systems and methods for surgical guidance and image registration are provided, in which three-dimensional image data associated with an object or patient is registered to topological image data obtained using a surface topology imaging device. The surface topology imaging device may be rigidly attached to an optical position measurement system that also tracks fiducial markers on a movable instrument. The instrument may be registered to the topological image data, such that the topological image data and the movable instrument are registered to the three-dimensional image data. The three-dimensional image data may be CT or MRI data associated with a patient. The system may also co-register images pertaining to a surgical plan with the three-dimensional image data. In another aspect, the surface topology imaging device may be configured to directly track fiducial markers on a movable instrument. The fiducial markers may be tracked according to surface texture.Type: GrantFiled: August 3, 2015Date of Patent: December 6, 2016Assignee: Ryerson UniversityInventors: Victor Xiao Dong Yang, Beau Anthony Standish, Adrian Linus Dinesh Mariampillai, Michael Ka Kit Leung
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Publication number: 20160030131Abstract: Systems and methods for surgical guidance and image registration are provided, in which three-dimensional image data associated with an object or patient is registered to topological image data obtained using a surface topology imaging device. The surface topology imaging device may be rigidly attached to an optical position measurement system that also tracks fiducial markers on a movable instrument. The instrument may be registered to the topological image data, such that the topological image data and the movable instrument are registered to the three-dimensional image data. The three-dimensional image data may be CT or MRI data associated with a patient. The system may also co-register images pertaining to a surgical plan with the three-dimensional image data. In another aspect, the surface topology imaging device may be configured to directly track fiducial markers on a movable instrument. The fiducial markers may be tracked according to surface texture.Type: ApplicationFiled: August 3, 2015Publication date: February 4, 2016Inventors: Victor Xiao Dong Yang, Beau Anthony Standish, Adrian Linus Dinesh Mariampillai, Michael Ka Kit Leung
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Patent number: 9119670Abstract: Systems and methods for surgical guidance and image registration are provided, in which three-dimensional image data associated with an object or patient is registered to topological image data obtained using a surface topology imaging device. The surface topology imaging device may be rigidly attached to an optical position measurement system that also tracks fiducial markers on a movable instrument. The instrument may be registered to the topological image data, such that the topological image data and the movable instrument are registered to the three-dimensional image data. The three-dimensional image data may be CT or MRI data associated with a patient. The system may also co-register images pertaining to a surgical plan with the three-dimensional image data. In another aspect, the surface topology imaging device may be configured to directly track fiducial markers on a movable instrument. The fiducial markers may be tracked according to surface texture.Type: GrantFiled: October 31, 2012Date of Patent: September 1, 2015Assignee: RYERSON UNIVERSITYInventors: Victor Xiao Dong Yang, Beau Anthony Standish, Adrian Linus Dinesh Mariampillai, Michael Ka Kit Leung
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Patent number: D727497Type: GrantFiled: July 3, 2013Date of Patent: April 21, 2015Assignee: 7D Surgical Inc.Inventors: Victor Yang, Peter Siegler, Adrian Linus Dinesh Mariampillai, Michael Ka Kit Leung, Beau Anthony Standish
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Patent number: D768296Type: GrantFiled: September 10, 2015Date of Patent: October 4, 2016Assignee: 7D SURGICAL, INC.Inventors: Ernest N. Corrao, Jr., Ronald G. Litke, Jr., Glenn Paul DiCostanzo, Peter Siegler, Kathleen Chancellor-Maddison, Adrian Linus Dinesh Mariampillai, Michael Ka Kit Leung, Beau Anthony Standish, Victor X. D. Yang
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Patent number: D778441Type: GrantFiled: September 10, 2015Date of Patent: February 7, 2017Assignee: 7D SURGICAL INC.Inventors: Ernest N. Corrao, Jr., Ronald G. Litke, Jr., Glenn Paul DiCostanzo, Peter Siegler, Kathleen Chancellor-Maddison, Adrian Linus Dinesh Mariampillai, Michael Ka Kit Leung, Beau Anthony Standish, Victor X. D. Yang