Abstract: Device data is obtained from one or more devices for an individual. The one or more devices include one or more medical monitoring devices. Data is also obtained from one or more exogenous sources, and the data includes current data relating to one or more medical resources. The device data obtained from the one or more devices and the data from the one or more exogenous sources are analyzed using an artificial intelligence agent. Based on the analyzing, one or more recommendations are provided. The one or more recommendations include an indication of a device to use that is different from the one or more devices to obtain different device data for the individual.

Abstract: The disclosure relates to methods and compositions for regulating expression of DUX4. In some aspects, methods described by the disclosure are useful for treating a disease associated with aberrant DUX4 expression (e.g., facioscapulohumeral muscular dystrophy).

Abstract: A stent delivery catheter assembly for delivering and implanting a self-expanding stent in a body lumen includes a handle assembly for one handed use. The handle assembly has a mode selection for advancing, reversing and locking the stent delivery components. Rotation of a thumbwheel allows the physician to deploy and implant the self-expanding stent in the body lumen with control and precision by simultaneously pulling a sheath proximally and pushing a pusher member distally.

Abstract: The present application describes various features for a catheter pump that prevents or inhibits unwanted fluids from entering a cavity or opening of a catheter pump. If unwanted fluids enter a cavity or opening of the catheter pump, the examples described herein cause the unwanted fluid to be expelled from the catheter pump.

Abstract: A septum for use in a catheter pump is provided herein. The septum includes a first elastomeric septa disc. The first elastomeric septa disc is punctured. The puncture forms an aperture in the first elastomeric septa disc. The aperture is passable by a guidewire.

Abstract: The present application describes various features for a catheter pump that prevents or inhibits unwanted fluids from entering a cavity or opening of a catheter pump. If unwanted fluids enter a cavity or opening of the catheter pump, the examples described herein cause the unwanted fluid to be expelled from the catheter pump.

Abstract: Various embodiments of a system for priming a catheter assembly are disclosed herein. For example, the system can include a catheter assembly including an elongate body and an operative device coupled thereto. The system can also include a priming vessel configured to receive insertion of the operative device therein. The priming vessel can include a proximal portion secured to the distal portion of the elongate body such that the elongate body is in fluid communication with the priming vessel. The priming vessel can also include a distal end through which air is expelled when a fluid is channeled through the elongate body and into the priming vessel to expel air from within the catheter assembly.

Abstract: A system and method for simulating an anatomical access site includes a model assembly selectively disposed within a carrying structure, the model assembly configured to present an anatomical simulant. The model assembly includes a liquid storage container configured to selectively hold a liquid, a pump configured to move the liquid at least around the anatomical simulant, and a model support assembly configured to support the anatomical simulant.

Abstract: A system for coupling a motor assembly to a control console is disclosed. The motor assembly is configured to drive a percutaneous heart pump. The system includes a motor coupling comprising a first end having an electrical connection and a fluid connection coupled to a respective electrical conduit and fluid conduit of the motor assembly, and a second end spaced apart from the first end including an interface coupling coupled to the electrical conduit and fluid conduit. An interface member is configured to be removably coupled to the control console, the interface member comprising a corresponding connector coupleable to the interface coupling of the second end of the motor coupling, wherein the interface member is configured to provide a sterile attachment of the fluid conduit to the control console.

Abstract: A motor system for a percutaneous heart pump includes a drive assembly that includes a motor and a housing having a proximal end and a distal end. The distal end of the housing is configured for coupling to a driven assembly. A first conduit is coupled to the proximal end of the drive assembly housing. The first conduit comprises an elongate tubular member including a communication interconnection line for transmitting communications from a remote console to the motor assembly. A second conduit is coupled to the proximal end of the drive assembly housing. The second conduit is configured for carrying a fluid between the remote console and the motor assembly.

Abstract: Various embodiments of a system for priming a catheter assembly are disclosed herein. For example, the system can include a catheter assembly including an elongate body and an operative device coupled thereto. The system can also include a priming vessel configured to receive insertion of the operative device therein. The priming vessel can include a proximal portion secured to the distal portion of the elongate body such that the elongate body is in fluid communication with the priming vessel. The priming vessel can also include a distal end through which air is expelled when a fluid is channeled through the elongate body and into the priming vessel to expel air from within the catheter assembly.

Abstract: Methods and devices for securing soft tissue to a rigid material such as bone are disclosed herein. A bone anchor is described that comprises a base and a top such that suture material may be compressed between surfaces on the base and top to secure the suture to the anchor. Also described is an inserter that can be used to insert the bone anchor into bone and move the anchor top relative to the anchor base to clamp suture material there between. Also described is a soft-tissue and bone piercing anchor and associated inserter. Methods are described that allow use of the bone anchors to provide multiple lengths of suture material to compress a large area of soft tissue against bone.

Abstract: Catheter comprising an inner tubular member defining a fluid lumen and inflation lumen therein. An exterior surface of the inner tubular member defines a fluid flow port in fluid communication with the fluid lumen and located along a region of the inner tubular member. Catheter further includes an outer member having a distal section movable relative to the inner tubular member and having an interior surface. A piston balloon is coupled to the inner tubular member distal to the fluid flow port and is in fluid communication with the inflation lumen. A pressure chamber is in fluid communication with the fluid flow port. Fluid introduced through the inflation lumen inflates the piston balloon to seal against the interior surface and fluid introduced through the fluid flow port and into the pressure chamber applies a force to urge at least the distal section of the outer member in a proximal direction.

Abstract: A system for delivering an implant including a handle, a trigger, an actuation assembly, and a catheter assembly. The actuation assembly is configured to displace the outer tubular member in the proximal direction and to separately move the inner shaft member distally upon deployment of the trigger from the first position to the second position, and move the inner shaft member proximally with no displacement of the outer tubular member upon return of the trigger from the second position to the first position. The catheter assembly includes an outer tubular member, an inner shaft member, and a pusher assembly.

Abstract: Various embodiments of a fluid handling system are disclosed herein. For example, the fluid handling system can include a catheter assembly and a console configured to control the operation of the catheter assembly. A removable interface member can be configured to provide fluid and electrical communication between the catheter assembly and the console.

Abstract: Methods and devices for securing soft tissue to a rigid material such as bone are disclosed herein. A bone anchor is described that comprises a base and a top such that suture material may be compressed between surfaces on the base and top to secure the suture to the anchor. Also described is an inserter that can be used to insert the bone anchor into bone and move the anchor top relative to the anchor base to clamp suture material there between. Also described is a soft-tissue and bone piercing anchor and associated inserter. Methods are described that allow use of the bone anchors to provide multiple lengths of suture material to compress a large area of soft tissue against bone.