Abstract: A transdermal drug delivery device includes a backing and an adhesive composition disposed on the backing. The adhesive composition includes a copolymer having at least 50 percent by weight C4 to C10 alkyl acrylate units, based on the total weight of the copolymer, and one or more second monomer units selected from the group consisting of vinyl acetate, acrylamide, ethyl acrylate, methyl acrylate, and N-vinyl-2-pyrrolidone. The C4 to C10 alkyl acrylate and the one or more second monomer units together make up at least 98 percent by weight of the copolymer. The adhesive composition further includes a skin permeation enhancer in a range from 5 percent to 25 percent by weight, based on the total weight of the adhesion composition, and fentanyl. The adhesive composition is substantially free of undissolved fentanyl. A method of treating a mammal including placing the transdermal drug delivery device on the mammal's skin is also disclosed.

Abstract: A system for measuring diffusion of a compound across a membrane generally comprises a membrane held between a first base having a plurality of outwardly extending hollow projections and a second base fastened to the first base and having a plurality of recessed tapered openings therein adapted to engage the plurality of hollow projections. Methods for measuring membrane diffusion using such systems are included. The system components are also provided in kit form.

Abstract: A transdermal delivery device including an adhesive layer that contains a therapeutically effective amount of testosterone and a delivery enhancing adjuvant comprising a terpene.