Abstract: Systems and apparatus related to adaptive support garments including adaptive support structures, lacing systems, and an adaptive engine are discussed. In an example, an adaptive support garment includes a support structure, a plurality of lace guides, a lace cable, and an adaptive engine. The support structure is configured to wrap around a portion of anatomy of a wearer and apply a compression on the portion of anatomy. The plurality of lace guides are disposed on the support structure. The lace cable extends through the lace guides to form a lacing pattern over a lacing region of the support structure. The adaptive engine is coupled to the support structure and engages with the lace cable. The adaptive engine is also configured to increase or decrease tension on the lace cable to increase or decrease compression of the support structure on the portion of anatomy, respectively.

Abstract: The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.

Abstract: A device includes: a first portion configured to be grasped by the hand of the user, and a second portion defining a reservoir containing a control material, wherein the control material contains a target analyte in a known or predetermined concentration. A method of verifying the accuracy of an analyte monitoring device includes receiving a fluid sample, identifying the fluid sample as a control solution, and analyzing the fluid sample.

Abstract: The present disclosure provides an acoustical substrate including nonwoven material which includes a two component adhesive system which may be treated with a fluid repelling compound. The two component adhesive system may comprise two adhesive components having different melting points to allow for flexible industrial post processing and laminating. The adhesives may be applied by a variety of methods and may exist in the substrate in, e.g., either discrete or continuous web forms.

Abstract: A plurality of self-supporting first and second panels are disposed in alternating arrangement along the length of an open tank. A seal is provided around the perimeter of the cover and along the joint between each of the first and second panels. Each of the first and second panels is provided with a handle at the end of each of the panels that, when in a stored position, lies flush with a walking surface provided on the top of the cover.

Abstract: A filter system for removing a material from a layer of water of selected depth beginning at the surface of a body of water. The system is designed to be mounted to a surface vessel specially adapted to receive the system. The surface vessel has an intake area at its bow. A water intake gate acts as a closure to the intake area. The inlet gate can be lowered to admit water to the intake area as the vessel is propelled through the body of water. An endless conveyer type filter screen is supported by rollers in the intake area. Water passing through the filter screen is discharged through ducts passing through the sides of the vessel. Material separated from the water is conveyed by the filter screen to other equipment for further processing.