Patents by Inventor Michael L. Schmidt
Michael L. Schmidt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11999791Abstract: The invention concerns methods for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.Type: GrantFiled: May 1, 2023Date of Patent: June 4, 2024Assignee: Genentech, Inc.Inventors: Yung-Hsiang Kao, Michael W. Laird, Melody Trexler Schmidt, Rita L. Wong, Daniel P. Hewitt
-
Patent number: 11987637Abstract: The invention concerns methods for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.Type: GrantFiled: January 11, 2024Date of Patent: May 21, 2024Assignee: Genentech, Inc.Inventors: Yung-Hsiang Kao, Michael W. Laird, Melody Trexler Schmidt, Rita L. Wong, Daniel P. Hewitt
-
Patent number: 11987638Abstract: The invention concerns methods for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.Type: GrantFiled: January 11, 2024Date of Patent: May 21, 2024Assignee: Genentech, Inc.Inventors: Yung-Hsiang Kao, Michael W. Laird, Melody Trexler Schmidt, Rita L. Wong, Daniel P. Hewitt
-
Publication number: 20240157130Abstract: Embodiments herein relate to implantable systems for cancer treatment and related methods. In an embodiment, an implantable system for cancer treatment can be included having a therapy output circuit configured to generate an electrical output for one or more electrodes to create one or more electric fields. The implantable system can include control circuitry that causes the therapy output circuit to generate the one or more electric fields at frequencies between 10 kHz and 1 MHz within a bodily tissue. The one or more electric fields can be effective to prevent and./or disrupt cellular mitosis in a cell. The implantable system can further include a therapy zone temperature sensor. The implantable system can be configured to measure the temperature and/or record the temperature data of a patient over time. The temperature data can include tissue temperature and time stamps of the same. Other embodiments are also included herein.Type: ApplicationFiled: November 3, 2023Publication date: May 16, 2024Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: Devon N. Arnholt, Michael J. Kane, Brian L. Schmidt
-
Publication number: 20240158527Abstract: The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.Type: ApplicationFiled: January 11, 2024Publication date: May 16, 2024Applicant: Genentech, Inc.Inventors: Yung-Hsiang KAO, Michael W. LAIRD, Melody Trexler SCHMIDT, Rita L. WONG, Daniel P. HEWITT
-
Publication number: 20240158368Abstract: Pyrrolidine main protease inhibitors are described that are effective as antiviral compounds.Type: ApplicationFiled: October 12, 2023Publication date: May 16, 2024Applicant: AbbVie Inc.Inventors: David A. Degoey, Michael R. Schrimpf, David J. Hardee, Jacob Ludwig, Eric R. Miller, Timothy R. Hodges, Alberto Munoz, Sarah J. Perlmutter, Huan-Qiu X. Li, Alvin Jang, Elizabeth L. Noey, Gregory A. Gfesser, Edgars Jecs, Robert G. Schmidt, Justin D. Dietrich, Xenia B. Searle, Boguslaw P. Nocek, Andrew Bogdan
-
Publication number: 20240150486Abstract: The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.Type: ApplicationFiled: January 11, 2024Publication date: May 9, 2024Applicant: Genentech, Inc.Inventors: Yung-Hsiang KAO, Michael W. LAIRD, Melody Trexler SCHMIDT, Rita L. WONG, Daniel P. HEWITT
-
Patent number: 11976127Abstract: The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.Type: GrantFiled: April 20, 2023Date of Patent: May 7, 2024Assignee: Genentech, Inc.Inventors: Yung-Hsiang Kao, Michael W. Laird, Melody Trexler Schmidt, Rita L. Wong, Daniel P. Hewitt
-
Publication number: 20240132612Abstract: The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.Type: ApplicationFiled: April 20, 2023Publication date: April 25, 2024Applicant: Genentech, Inc.Inventors: Yung-Hsiang Kao, Michael W. Laird, Melody Trexler Schmidt, Rita L. Wong, Daniel P. Hewitt
-
Patent number: 11957894Abstract: A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes.Type: GrantFiled: August 25, 2020Date of Patent: April 16, 2024Assignee: Medtronic, Inc.Inventors: Anthony M. Chasensky, Bernard Q. Li, Brad C. Tischendorf, Chris J. Paidosh, Christian S. Nielsen, Craig L. Schmidt, David A. Dinsmoor, Duane L. Bourget, Eric H. Bonde, Erik R. Scott, Forrest C M Pape, Gabriela C. Molnar, Gordon O. Munns, Joel A. Anderson, John E. Kast, Joseph J. Viavattine, Markus W. Reiterer, Michael J. Ebert, Phillip C. Falkner, Prabhakar A. Tamirisa, Randy S. Roles, Reginald D. Robinson, Richard T. Stone, Shawn C. Kelley, Stephen J. Roddy, Thomas P. Miltich, Timothy J. Denison, Todd V. Smith, Xuan K. Wei
-
Patent number: 11957893Abstract: A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes.Type: GrantFiled: August 25, 2020Date of Patent: April 16, 2024Assignee: Medtronic, Inc.Inventors: Brad C. Tischendorf, John E. Kast, Thomas P. Miltich, Gordon O. Munns, Randy S. Roles, Craig L. Schmidt, Joseph J. Viavattine, Christian S. Nielsen, Prabhakar A. Tamirisa, Anthony M. Chasensky, Markus W. Reiterer, Chris J. Paidosh, Reginald D. Robinson, Bernard Q. Li, Erik R. Scott, Phillip C. Falkner, Xuan K. Wei, Eric H. Bonde, David A. Dinsmoor, Duane L. Bourget, Forrest C M Pape, Gabriela C. Molnar, Joel A. Anderson, Michael J. Ebert, Richard T. Stone, Shawn C. Kelley, Stephen J. Roddy, Timothy J. Denison, Todd V. Smith
-
Patent number: 11949554Abstract: A CPE device may include a plurality of CPE modules implemented in hardware. The plurality of CPE modules may include a first module and a second module. The first module and the second module may be arrangeable in a stacked configuration. The first module may include a first interconnection interface component disposed on a top surface of the first module. The second module may include a second interconnection interface component disposed on a bottom surface of the second module. The second interconnection interface component may be configured to complementarily couple to the first interconnection interface component when the first module and the second module are arranged in the stacked configuration.Type: GrantFiled: March 15, 2021Date of Patent: April 2, 2024Assignee: Verizon Patent and Licensing Inc.Inventors: Michael Talbert, Meaghan Leong, Christina L. Fyock, Aldrich Gamboa, Christopher M. Schmidt
-
Publication number: 20180363105Abstract: A method of manufacturing a ferrous alloy article is disclosed and includes the steps of melting a ferrous alloy composition into a liquid, atomizing and solidifying the liquid into powder particles, removing oxygen from surfaces of the powder particles to reduce a bulk oxygen content to approximately ?20 ppm, and consolidating the powder particles into a monolithic article.Type: ApplicationFiled: August 23, 2018Publication date: December 20, 2018Applicant: CRS Holdings Inc.Inventors: David E. Wert, Timothy R. Armstrong, David A. Helmick, Michael L. Schmidt
-
Publication number: 20180320256Abstract: A precipitation hardenable, martensitic stainless steel alloy is disclosed. The alloy has the following composition in weight percent, about C 0.03 max Mn 1.0 max Si 0.75 max P 0.040 max S 0.020 max Cr 10-13 Ni 10.5-11.6 Mo 0.25-1.5? Co 0.5-1.5 Cu 0.75 max Ti 1.5-1.8 Al 0.3-0.8 Nb 0.3-0.8 B 0.010 max N 0.030 max The balance is iron and usual impurities. The disclosed alloy provides a unique combination of corrosion resistance, strength, and toughness.Type: ApplicationFiled: July 12, 2018Publication date: November 8, 2018Inventors: David E. Wert, Michael L. Schmidt
-
Patent number: 10094007Abstract: A method of manufacturing a ferrous alloy article is disclosed and includes the steps of melting a ferrous alloy composition into a liquid, atomizing and solidifying of the liquid into powder particles, outgassing to remove oxygen from the surface of the powder particles, and consolidating the powder particles into a monolithic article.Type: GrantFiled: May 20, 2014Date of Patent: October 9, 2018Assignee: CRS Holdings Inc.Inventors: David E. Wert, Timothy R. Armstrong, David A. Helmick, Michael L. Schmidt
-
Publication number: 20170185759Abstract: Various systems and methods for implementing EMG-based liveness detection are described herein. An EMG-based liveness detection system incorporated into a wearable device includes a plurality of electrodes to sense EMG signal data of a user; an amplifier to amplify the EMG signal data; a filter to remove signal noise from the EMG signal data; an analog-to-digital converter to analyze the EMG signal data and convert it to digital data; and a controller to: authenticate the user; perform an EMG-based liveness test of the user based on the digital data; and disable the wearable device when the EMG-based liveness test fails.Type: ApplicationFiled: December 23, 2015Publication date: June 29, 2017Inventors: Michael L. Schmidt, Indira Negi, Alberto Vidal
-
Publication number: 20160319406Abstract: A precipitation hardenable, martensitic stainless steel alloy is disclosed. The alloy has the following composition in weight percent, about C 0.03 max Mn 1.0 max Si 0.75 max P 0.040 max S 0.020 max Cr 10-13 Ni 10.5-11.6 Mo 0.25-1.5? Co 0.5-1.5 Cu 0.75 max Ti 1.5-1.8 Al 0.3-0.8 Nb 0.3-0.8 B 0.010 max N 0.030 max The balance is iron and usual impurities. The disclosed alloy provides a unique combination of corrosion resistance, strength, and toughness.Type: ApplicationFiled: July 14, 2016Publication date: November 3, 2016Inventors: David E. Wert, Michael L. Schmidt
-
Patent number: 9267192Abstract: A corrosion resistant, neutron absorbing, austenitic alloy powder is disclosed having the following composition in weight percent. C 0.08 max. Mn up to 3 Si up to 2 P 0.05 max. S 0.03 max. Cr 17-27 Ni 11-20 Mo + (W/1.92) ??up to 5.2 BEq 0.78-13.0 O ?0.1 max. N ??up to 0.2 Y less than 0.005 The alloy contains at least about 0.25% B, at least about 0.05% Gd, and the balance of the alloy composition is iron and usual impurities. BEq is defined as % B+4.35×(% Gd). An article of manufacture made from consolidated alloy powder is also disclosed which is characterized by a plurality of boride and gadolinide particles dispersed within a matrix. The boride and gadolinide particles are predominantly M2B, M3B2, M3X, and M5X in form, where X is gadolinium or a combination of gadolinium and boron and M is one or more of the elements silicon, chromium, nickel, molybdenum, iron.Type: GrantFiled: August 25, 2011Date of Patent: February 23, 2016Assignee: CRS HOLDINGS, INC.Inventors: Michael L. Schmidt, Gregory J. Del Corso, Patrick C. Ray, Ning Ma
-
Publication number: 20150118095Abstract: A method of manufacturing a ferrous alloy article is disclosed and includes the steps of melting a ferrous alloy composition into a liquid, atomizing and solidifying of the liquid into powder particles, outgassing to remove oxygen from the surface of the powder particles, and consolidating the powder particles into a monolithic article.Type: ApplicationFiled: May 20, 2014Publication date: April 30, 2015Applicant: CRS HOLDINGS INC.Inventors: David E. Wert, Timothy R. Armstrong, David A. Helmick, Michael L. Schmidt
-
Publication number: 20140161658Abstract: A precipitation hardenable, martensitic stainless steel alloy is disclosed. The alloy has the following composition in weight percent, about C ?0.03 max Mn ?1.0 max Si ?0.75 max P 0.040 max S 0.020 max Cr 10-13 Ni 10.5-11.6 Mo 0.25-1.5? Co 0.5-1.5 Cu ?0.75 max Ti 1.5-1.8 Al 0.3-0.8 Nb 0.3-0.8 B 0.010 max N 0.030 max The balance is iron and usual impurities. The disclosed alloy provides a unique combination of corrosion resistance, strength, and toughness.Type: ApplicationFiled: December 6, 2012Publication date: June 12, 2014Applicant: CRS HOLDINGS, INC.Inventors: David E. Wert, Michael L. Schmidt