Abstract: A liquid transfer device for use in combination with a container and a syringe to facilitate removal of liquid from a container by the syringe includes an obstruction member positioned in an outlet of the container. The obstruction member has a concave inner surface facing the container interior to direct liquid to a passageway in the obstruction member when the container is inverted. A seal is formed between the obstruction member and the syringe spout and the spout is positioned by the obstruction member with the distal end of the spout located either in the passageway or projecting from the passageway toward the container interior and disposed closely adjacent to the inner surface of the obstruction member.