Abstract: Provided herein is an antifolate predictive response signature for use in determining the response of a subject suffering from cancer to antifolate therapy. Also provided are methods and compositions for determining proliferation in a sample obtained from a subject suffering from cancer through the use of a proliferation gene signature as well as methods for predicting response of a subject suffering from cancer based on an assessment of proliferation in a sample obtained from the subject.

Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: Systems and methods for secure updating of allocations to user accounts are provided. In one aspect, a system includes one or more computer readable storage mediums having program instructions embodied therewith, and one or more processors configured to cause the system to identify an external institution associated with the future transfers, and initiate, based on the identified external institution, a proxy instance of a software application of the external institution to determine a set of endpoints and a set of the future transfers to the endpoints. The system is further configured to receive a request from a user to change at least one of the set of the endpoints and the set of the further transfers to the endpoints, and use the proxy instance, executing the requested change to at least one of the set of the endpoints or the set of the future transfers to the endpoints.

Abstract: The present disclosure relates to a ground connection terminal for fastening a ground connection cable to a field device of process and automation technology. The ground connection terminal comprises a connection element for connecting the ground connection terminal to the field device, and a clamping body for clamping the ground connection cable.

Abstract: Systems and methods are disclosed for automated lateral transfer and elevation of sortation shuttles. An example system may include a track having a first portion arranged in a first direction, a shuttle configured to move along the track, and a shuttle carriage system configured to move in a second direction transverse to the first direction, where the shuttle is configured to move from the track to the shuttle carriage system. The shuttle carriage system may include a first frame configured to support the shuttle, a first electromagnet configured to propel the first frame, and a second electromagnet coupled to the first frame, the second electromagnet configured to propel the shuttle off the first frame.

Abstract: A telepresence robot may include a drive system, a control system, an imaging system, and a mapping module. The mapping module may access a plan view map of an area and tags associated with the area. In various embodiments, each tag may include tag coordinates and tag information, which may include a tag annotation. A tag identification system may identify tags within a predetermined range of the current position and the control system may execute an action based on an identified tag whose tag information comprises a telepresence robot action modifier. The telepresence robot may rotate an upper portion independent from a lower portion. A remote terminal may allow an operator to control the telepresence robot using any combination of control methods, including by selecting a destination in a live video feed, by selecting a destination on a plan view map, or by using a joystick or other peripheral device.

Abstract: The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.

Abstract: Systems and methods for secure updating of allocations to user accounts are provided. In one aspect, a system includes one or more computer readable storage mediums having program instructions embodied therewith, and one or more processors configured to cause the system to identify an external institution associated with the future transfers, and initiate, based on the identified external institution, a proxy instance of a software application of the external institution to determine a set of endpoints and a set of the future transfers to the endpoints. The system is further configured to receive a request from a user to change at least one of the set of the endpoints and the set of the further transfers to the endpoints, and use the proxy instance, executing the requested change to at least one of the set of the endpoints or the set of the future transfers to the endpoints.

Abstract: A method for compacting data includes storing a first plurality of files at a first datacenter and storing a second plurality of files at a second datacenter. The method also includes generating a parity file that includes parity calculations of the first plurality of files and the second plurality of files. The method includes storing the parity file at a third datacenter. The method also includes receiving a request to delete a first file of the first plurality of files stored at the first datacenter and, in response to the request to delete the first file, compacting the parity file stored at the third datacenter. After compacting the parity file, the method includes determining whether a data compaction cost threshold is satisfied. When the data compaction cost threshold is satisfied, the method includes compacting the first plurality of files stored at the first datacenter.

Abstract: The present disclosure relates to a connecting element for electrical connecting two electrical modules arranged in a transmitter housing of a field device, into which transmitter housing the connecting element is insertable, the connecting element including: at least two essentially rod-shaped metal conductor elements, each with two opposing end sections, wherein the conductor elements are arranged in a defined separation relative to one another; and surrounding the conductor elements and electrically insulating them from one another, a multi-membered insulating body including two insulating body end segments of at least a first synthetic material and an insulating body intermediate segment of a second synthetic material different from the first synthetic material, wherein the first synthetic material has a modulus of elasticity greater than a modulus of elasticity of the second synthetic material.

Abstract: Systems and methods for secure updating of allocations to user accounts are provided. In one aspect, a system includes one or more computer readable storage mediums having program instructions embodied therewith, and one or more processors configured to cause the system to identify an external institution associated with the future transfers, and initiate, based on the identified external institution, a proxy instance of a software application of the external institution to determine a set of endpoints and a set of the future transfers to the endpoints. The system is further configured to receive a request from a user to change at least one of the set of the endpoints and the set of the further transfers to the endpoints, and use the proxy instance, executing the requested change to at least one of the set of the endpoints or the set of the future transfers to the endpoints.

Abstract: The present disclosure relates to a field device of automation technology, comprising a housing and a sensor unit sensitive for a process variable of a medium. The housing has a passageway to accommodate the sensor unit and the sensor unit protrudes from the housing through a terminal opening of the passageway. A clamping angle and a screw are introduced into the housing in a region of the housing adjoining the opening of the passageway. By means of the screw the clamping angle is shiftable in the housing a predeterminable distance in the direction of the sensor unit, and the clamping angle shifted in the direction of the sensor unit is embodied to press with a first clamping angle section of the clamping angle radially on a clamping region of the sensor unit arranged in the housing and facing the opening of the passageway.

Abstract: The present invention relates to an arrangement for fastening a capacitor cup within which a capacitor is accommodated. The arrangement is for fastening a capacitor cup onto an opening of a mid-plate, wherein the capacitor cup comprises a cylindrical body having an opening end and an opposite end. The arrangement comprises: a collar provided on an outer surface of the cylindrical body, closely around the opening end; at least one first engagement feature formed at the outer surface of the cylindrical body and adjacent to the collar; and, at least one second engagement feature, corresponding to the first engagement feature, formed at an edge of the opening of the mid-plate; wherein, an engagement between the first and second engagement features fastens the capacitor cup onto the opening of the mid-plate.

Abstract: Embodiments described herein are generally directed towards systems and methods relating to a crowd-sourced digital assistant system and related methods. In particular, embodiments facilitate techniques to crowdsource the training of a language model of the crowd-sourced digital assistant system. The digital assistant device can generate new action datasets based on manual inputs detected by the digital assistant device. The manual inputs can be recorded as a set of instructions, which can be interpreted by another digital assistant device to reproduce the detected manual inputs based on a command received by the other digital assistant device. The digital assistant server can receive action datasets, maintain action datasets, and distribute action datasets to one or more digital assistant devices. In various embodiments, the digital assistant device or server can also determine whether received action datasets are related.

Abstract: The present disclosure relates to a field device of automation technology, comprising a housing and a sensor unit sensitive for a process variable of a medium. The housing has a passageway to accommodate the sensor unit and the sensor unit protrudes from the housing through a terminal opening of the passageway. A clamping angle and a screw are introduced into the housing in a region of the housing adjoining the opening of the passageway. By means of the screw the clamping angle is shiftable in the housing a predeterminable distance in the direction of the sensor unit, and the clamping angle shifted in the direction of the sensor unit is embodied to press with a first clamping angle section of the clamping angle radially on a clamping region of the sensor unit arranged in the housing and facing the opening of the passageway.

Abstract: The present disclosure relates to a connecting element for electrical connecting two electrical modules arranged in a transmitter housing of a field device, into which transmitter housing the connecting element is insertable, the connecting element including: at least two essentially rod-shaped metal conductor elements, each with two opposing end sections, wherein the conductor elements are arranged in a defined separation relative to one another; and surrounding the conductor elements and electrically insulating them from one another, a multi-membered insulating body including two insulating body end segments of at least a first synthetic material and an insulating body intermediate segment of a second synthetic material different from the first synthetic material, wherein the first synthetic material has a modulus of elasticity greater than a modulus of elasticity of the second synthetic material.

Abstract: The present invention relates to an arrangement for fastening a capacitor cup within which a capacitor is accommodated. The arrangement is for fastening a capacitor cup onto an opening of a mid-plate, wherein the capacitor cup comprises a cylindrical body having an opening end and an opposite end. The arrangement comprises: a collar provided on an outer surface of the cylindrical body, closely around the opening end; at least one first engagement feature formed at the outer surface of the cylindrical body and adjacent to the collar; and, at least one second engagement feature, corresponding to the first engagement feature, formed at an edge of the opening of the mid-plate; wherein, an engagement between the first and second engagement features fastens the capacitor cup onto the opening of the mid-plate.

Abstract: A system and method for optimizing multiple invocations of a graphics processing unit (GPU) program in Java. In one embodiment, the system includes: (1) a frontend component in a computer system and configured to compile Java bytecode associated with the a class object that implements a functional interface into Intermediate Representation (IR) code and store the IR code with the associated jogArray and (2) a collector/composer component in the computer system, associated with the frontend and configured to traverse a tree containing the multiple invocations from the result to collect the IR code and compose the IR code collected in the traversing into aggregate IR code when a result of the GPU program is explicitly requested to be transferred to a host.

Abstract: A measuring transducer for metrological registering of a pressure to be measured as relative pressure referenced to a reference pressure reigning in the environment of the measuring transducer, comprising: a housing; a relative pressure sensor arranged in the housing; a pressure supply, via which the pressure to be measured is fed to the relative pressure sensor, and a reference pressure supply, via which the reference pressure is fed to the relative pressure sensor. An entrance of and to the reference pressure supply communicates with an opening in a housing outer wall, on whose exterior the reference pressure acts, characterized in that a pressure equalizing element is applied in the entrance of the reference pressure supply, and the pressure equalizing element has a securement element, a filter element and a protective cap.

Abstract: Embodiments described herein are generally directed towards systems and methods relating to a crowd-sourced digital assistant system and related methods. In particular, embodiments facilitate techniques to crowdsource the training of a language model of the crowd-sourced digital assistant system. The digital assistant device can generate new action datasets based on manual inputs detected by the digital assistant device. The manual inputs can be recorded as a set of instructions, which can be interpreted by another digital assistant device to reproduce the detected manual inputs based on a command received by the other digital assistant device. The digital assistant server can receive action datasets, maintain action datasets, and distribute action datasets to one or more digital assistant devices. In various embodiments, the digital assistant device or server can also determine whether received action datasets are related.