Abstract: Described are systems, devices, and methods which related to various aspects of assays for detecting and/or determining a measure of the concentration of analyte molecules or particles in a sample fluid. In some cases, the systems employ an assay consumable comprising a plurality of assay sites. The systems, devices, and/or methods, in some cases, are automated. In some cases, the systems, devices, and/or methods relate to inserting a plurality of beads into assay sites, sealing assay sites, imaging assay sites, or the like.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A method for rotatable selection of sites for cannulation of a subcutaneous vascular access vessel comprises the step of providing a template defining an opening for a plurality of zones, each of the plurality of zones configured for receiving a plurality of simultaneous cannulations accessing the vascular access vessel. The outer surface of the template is marked, the marking defining each of the plurality of zones for use as cannulation sites along the vascular access vessel. The template is positioned on the skin of the patient adjacent the subcutaneous vascular access vessel such that the opening aligns with the vascular access vessel, and the marking is used for selecting a first zone for a cannulation site into the vascular access vessel such that the cannulation site in the first zone is spaced from and not adjacent to a second zone used for cannulation immediately previously to the first zone.

Abstract: An apparatus is provided for rotatable selection of sites for cannulation with a needle along a subcutaneous vascular access vessel. The cannulation site selection apparatus comprises a template having an inner surface and an outer surface, and a plurality of visible markings on the outer surface of the template. The template is adapted to be disposed adjacent the subcutaneous vascular access vessel such that the markings align with the cannulation sites along the vascular access vessel for selecting a site for cannulation with a needle into the vascular access vessel.

Abstract: A quantitative simulation process for producing quantitative model predictions of hydrocarbon composition. The quantitative simulation may include measuring a chemical and isotopic composition of a hydrocarbon sample from a hydrocarbon reservoir.

Abstract: A respiratory flow therapy apparatus including a sensing chamber which measures a flow of gases provided to a patient. The sensing chamber can be located after a blower and/or mixer. The sensing chamber can include an ultrasonic transducer, a temperature sensor, a heated temperature sensing element, and/or a gas concentration sensor. A flow path of gases used in conjunction with the sensor system prevents unwanted vorticity in the flow of gases that can create anomalies in measuring flow.

Abstract: A respiratory flow therapy apparatus including a sensing chamber which measures a flow of gases provided to a patient. The sensing chamber can be located after a blower and/or mixer. The sensing chamber can include an ultrasonic transducer, a temperature sensor, a heated temperature sensing element, and/or a gas concentration sensor. A flow path of gases used in conjunction with the sensor system prevents unwanted vorticity in the flow of gases that can create anomalies in measuring flow.

Abstract: A method and system for the suppression and/or modulation of absorption spectrum artifacts for the purpose of gas detection and concentration measurements using at least one magnetic, electric or electromagnetic field. A field applied selectively to at least one section of the system modulates absorption by influencing quantum energy state transitions of gas species.

Abstract: An apparatus for delivering a flow of gas, has a housing 3202? with a recess, and an outlet port 3210? for a flow of gas. The recess is defined by at least one wall 3256, 3262 that is substantially continuous, gas impermeable, and unbroken, other than a gasflow passage from the recess to the outlet port of the housing.

Abstract: An apparatus for delivering a flow of gas has a housing and a humidifier. The housing has a recess for a motor and/or sensor module, an outlet port for a flow of gas, and a removable elbow for a flow of gas. The humidifier has a heater, a chamber bay for receipt of a liquid chamber, and a lever and/or detent(s) for assisting with insertion and/or retention and/or removal of the liquid chamber in and/or from the chamber bay.

Abstract: An embodiment method for managing geographic information includes receiving, at a service portal, executed lease data for mineral rights leases on associated first land parcels, generating first map data according to the executed lease data, and sending the first map data through a network interface to a client application for display to a first user at a first remote terminal. The method further includes receiving, from the first remote terminal, data for a proposed division order boundary, determining one or more of the first land parcels having boundaries that at least partly overlap the proposed division order boundary, generating division order data related to portions of the one or more first land parcels, and sending the division order data to the first remote terminal for display to the user.

Abstract: A quantitative simulation process for producing quantitative model predictions of hydrocarbon composition may comprise: measuring a chemical and isotopic composition of a hydrocarbon sample from a hydrocarbon reservoir; measuring geochemical data, geophysical data, and/or geological data for the hydrocarbon reservoir and/or source rock; deriving temperature versus time relationships from a basin model for the hydrocarbon reservoir and/or source rock based on the geochemical data, geophysical data, and/or geological data; generating estimated source-rock maturity parameters based on the temperature versus time relationships; generating an estimated compositional yield for hydrocarbon fractions based on the temperature versus time relationships and the chemical composition of the hydrocarbon sample; and generating, using a mass-conserving isotopic fraction (MCIF) simulator, an estimated isotopic composition of the hydrocarbon fractions based on the estimated compositional yield and the isotopic composition of t

Abstract: Described herein are methods and techniques for determining one or more characteristics of a hydrocarbon source. The method comprises obtaining a hydrocarbon fluid sample, determining at least one measured clumped isotope signature or measured position specific isotope signature for at least one hydrocarbon species of interest in the hydrocarbon fluid sample, determining at least one expected clumped isotope signature or expected position specific isotope signature for the hydrocarbon species of interest, comparing the measured clumped isotope signature or measured position specific isotope signature with the expected clumped isotope signature or expected position specific isotope signature, and determining at least one characteristic of the source of the hydrocarbon sample based on the comparison.

Abstract: A system and method is provided for enhancing hydrocarbon production. The method and system involve geochemistry analysis and include multiply substituted isotopologue and position specific isotope geochemistry. The method and system involve using clumped isotope and position-specific isotope signatures to enhance reservoir surveillance operations.

Abstract: An apparatus is provided for subcutaneous implantation in a patient using a tunneling instrument. The implantation apparatus comprises a vascular graft and a connector adapted to couple a distal end of the tunneling instrument and a proximal end of the graft. The connector comprises a tip, a first end of the tip configured to be received within the proximal end of the graft, a clip for securing the graft to the tip, and a coupler for a rotatable connection of the tip to the tunneling instrument such that the tip is rotatable about its longitudinal axis relative to the coupler to facilitate attachment of the graft to the tunneling instrument. The implantation apparatus may further comprise a removable sheath configured to substantially cover the length of the graft.

Abstract: An aircraft landing gear includes a shock strut with a rod slidably received within a cylinder. A beam is rotatably mounted to the rod, and wheels are mounted to the beam. The landing gear further includes a link assembly with an upper link and a lower link. The upper link has a first end rotatably connected to the cylinder, and the lower link has a first end rotatably connected to the beam. The second ends of the upper and lower links are rotatably coupled to each other by a limiter joint. The limiter joint includes a first stop associated with the upper link and a second stop associated with the lower link. The stops are configured such that the first stop engages the second stop to limit rotation of the upper link relative to the lower link.

Abstract: A foldable, elevating walker chair is disclosed having a height adjustment mechanism and a height limiter. The elevating walker chair has a unique lifting mechanism that allows the chair to be readily raised and lowered without motors. The weight of the elevating walker chair may be optimized by use of innovative bracing struts. The folding mechanism allows the elevating walker chair to achieve a compact configuration. Innovative components such as a swivel seat, hinges, seatbelt, telescoping wheel mounts, height adjustment devices and safety mechanisms may be included in the elevating walker chair.

Abstract: An apparatus is provided for subcutaneous implantation in a patient using a tunneling instrument. The implantation apparatus comprises a vascular graft and a connector adapted to couple a distal end of the tunneling instrument and a proximal end of the graft. The connector comprises a tip, a first end of the tip configured to be received within the proximal end of the graft, a clip for securing the graft to the tip, and a coupler for a rotatable connection of the tip to the tunneling instrument such that the tip is rotatable about its longitudinal axis relative to the coupler to facilitate attachment of the graft to the tunneling instrument. The implantation apparatus may further comprise a removable sheath configured to substantially cover the length of the graft.

Abstract: An aircraft landing gear includes a shock strut with a rod slidably received within a cylinder. A beam is rotatably mounted to the rod, and wheels are mounted to the beam. The landing gear further includes a link assembly with an upper link and a lower link. The upper link has a first end rotatably connected to the cylinder, and the lower link has a first end rotatably connected to the beam. The second ends of the upper and lower links are rotatably coupled to each other by a limiter joint. The limiter joint includes a first stop associated the upper link and a second stop associated with the lower link. The stops are configured such that the first stop engages the second stop to limit rotation of the upper link relative to the lower link.

Abstract: A method for rotatable selection of sites for cannulation of a subcutaneous vascular access vessel comprises the step of providing a template defining an opening for a plurality of zones, each of the plurality of zones configured for receiving a plurality of simultaneous cannulations accessing the vascular access vessel. The outer surface of the template is marked, the marking defining each of the plurality of zones for use as cannulation sites along the vascular access vessel. The template is positioned on the skin of the patient adjacent the subcutaneous vascular access vessel such that the opening aligns with the vascular access vessel, and the marking is used for selecting a first zone for a cannulation site into the vascular access vessel such that the cannulation site in the first zone is spaced from and not adjacent to a second zone used for cannulation immediately previously to the first zone.