Abstract: The example systems, methods, and/or computer-readable media described herein help with design treatment plans for orthodontic treatments. Treatment templates expressed according to treatment domain-specific protocols may be processed to provide treatment planning software, including automated or real-time treatment planning software, that accommodates treatment preferences of a practitioner and/or patient data relevant to a treatment plan. These methods and systems may be also be useful for planning, designing and producing as series of dental appliances (e.g., aligners).

Abstract: Techniques for providing contextual forensic data based on user activities. A first method includes identifying a user action in user activity data, wherein the user action is a discrete event initiated by a user, wherein the user action is performed with respect to a portion of a system; and correlating the identified user action with at least one system change, wherein the at least one system change is related to the portion of the system, wherein the at least one system change occurred after the user action. A second method includes taking a first snapshot before a user action occurs, wherein the user action is a discrete event initiated by a user, wherein the first snapshot is taken of at least a portion of a system; and taking a second snapshot after the user action occurs, wherein the second snapshot is taken of the at least a portion of the system.

Abstract: Described herein are method of generating and uses of polypeptides with dual binding specificity, wherein the polypeptides contain a first binding-site for a first antigen and a second binding-site for a second antigen. The second binding-site comprises amino acid variants of native amino acid sequences of polypeptides that bind to the first antigen, wherein the variants do not abrogate binding to said first antigen. In one embodiment, polypeptides with dual binding specificity to PD1 and OX40 are disclosed herein. In another embodiment, polypeptides with dual binding specificity to PD1 and GITR are disclosed herein.

Abstract: Disclosed are engineered multicellular organisms. Also disclosed are systems and methods for designing, preparing, and utilizing the engineered multicellular organisms including methods of modulating tissue formulation and healing.

Abstract: Described herein are engineered anti-IL-2 antibodies with modified amino acid sequences. The engineered antibodies would confer modified receptor binding specificity to an IL-2-anti-IL2 antibody complex, inhibiting the binding of IL-2 to CD25. The engineered anti-IL-2 antibodies would facilitate expansion of subsets of effector immune cells and decrease undesirable effects caused by IL-2. Thus, the engineered anti-IL-2 antibodies would be useful in treating disease such as cancer and infection.

Abstract: Systems and methods are provided for storing a first data object comprising a first set of immutable components, the first data object being associated with a corresponding second data object stored by a remote replication system. A difference is determined between the first set of immutable components of the first data object and a second set of immutable components of the corresponding second data object. A subset of immutable components is identified from the first set of immutable components based on the difference. The subset of immutable components from the first set of immutable components is provided to the remote replication system over a communication network.

Abstract: The present disclosure relates in some aspects to methods and compositions for processes for inverting oligonucleotide molecules in an in situ synthesized array, including reversing the orientation of the oligonucleotide molecules with respect to the array substrate from 3?-immobilized to 5?-immobilized.

Abstract: A plurality of control-signal generators are configured to generate respective control signals having respective control-signal amplitudes and different respective control-signal frequencies, and a plurality of signal adders are configured to produce respective composite signals for application to a subject, by adding the control signals to respective ablation signals having respective ablation-signal amplitudes. The control-signal generators are configured to generate the control signals such that respective ratios between the control-signal amplitudes and the ablation-signal amplitudes are constant during the application of the composite signals to the subject.

Abstract: Systems and methods are provided for storing a first data object comprising a first set of immutable components, the first data object being associated with a corresponding second data object stored by a remote replication system. A difference is determined between the first set of immutable components of the first data object and a second set of immutable components of the corresponding second data object. A subset of immutable components is identified from the first set of immutable components based on the difference. The subset of immutable components from the first set of immutable components is provided to the remote replication system over a communication network.

Abstract: The present application relates to processor-implemented methods for determining a diagnostic outcome comprising receiving signals generated by an array of electro-chemical sensors in solution with a biological sample from a subject, each sensor of the array of electro-chemical sensors configured to generate a signal in response to one or more amplification reactions occurring in the solution, the one or more amplification reactions being indicative of the presence of an RNA host-response; processing the signals received from the array of electro-chemical sensors; based on the processing, assigning at least one value to the sample, the at least one value being indicative of a likelihood of the diagnostic outcome; based on the at least one assigned value, determining the diagnostic outcome.

Abstract: An apparatus includes two or more medical systems and a low impedance path. The two or more medical systems have respective electrical outputs and respective separate isolation grounds each isolated from power lines and from earth ground, wherein the two or more medical systems are electrically coupled one with the other via the patient. The low impedance path connects the separate isolation grounds of the medical systems to one another, causing one or more leakage currents to flow via the low impedance path instead of via the patient.

Abstract: A power line interference (PLI) suppression method includes receiving an input analog signal superimposed with PLI, and digitally estimating one or more harmonics of the PLI in real-time. Responsively to the one or more digitally estimated harmonics, one or more analog harmonic waveforms are outputted, that match the respective one or more harmonics of the PLI. The input analog signal and the one or more analog harmonic waveforms are received, and the superimposed PLI in the input analog signal is suppressed using the one or more analog harmonic waveforms. An analog output signal is outputted, that corresponds to the input analog signal having the suppressed PLI.

Abstract: An ablation system includes multiple electrodes configured to contact body tissue of a patient, including two or more ablation electrodes for contacting respective locations in a target organ and a return electrode. A signal-generating unit includes multiple signal generators, which are configured to apply respective composite signals to respective ones of the ablation electrodes. The composite signals include multiple, respective signal components, including respective ablation signals, having different, respective ablation-signal amplitudes and phases at a common ablation-signal frequency, and respective probe signals having respective probe-signal amplitudes and different respective probe-signal frequencies. A processor is coupled to measure the probe signals received by each of the multiple electrodes, and responsively to the measured probe signals, to control the ablation-signal amplitudes and phases.

Abstract: Disclosed are engineered multicellular organisms. Also disclosed are systems and methods for designing, preparing, and utilizing the engineered multicellular organisms.

Abstract: A method and system are directed to designing a low-dropout regulator (LDO) circuit and using the LDO circuit to detect recycled counterfeit integrated circuits. The LDO circuit includes, in part, a reference path circuit and a stressed path circuit. Each of the reference path circuit and the stressed path circuit is coupled to a control signal that can enable the corresponding path circuit for the LDO. LDO parameters can then be measured while the reference path circuit and the stressed path circuit is enabled respectively. The difference between the LDO parameters measured while the reference path circuit is enabled and while the stressed path circuit is enabled is used to determine if an integrated circuit comprising the LDO circuit is a recycled counterfeit.

Abstract: Provided herein are methods for promoting biostasis or preservation of a cell, tissue or organ during cancer treatment or for transplantation comprising contacting the cell, tissue or organ with an agonist of the ?-opioid receptor, SNC-80, an or Donepezil. Further provided herein is a method of treating a hematological neoplastic disease.

Abstract: Methods and systems are provided for regulating the temperature of rear axle lubrication oil. In one example, a rear axle coolant system may include a coolant loop with a plurality of valves and sensors, regulating the coolant flow in heat exchange relationship with an exhaust gas heat recovery and storage system to deliver warm coolant to a rear axle heat exchanger to warm the rear axle lubrication oil. The method may regulate the components of the rear axle coolant system through a controller, receiving sensor input from the components of the coolant system.

Abstract: An auto-injector is provided which includes a housing with a syringe slidably received therein. The syringe has a barrel with a piston movable therein and a needle extending therefrom. The piston is releasably secured to one end of a plunger which is slidably secured within a body in the housing and is operable through a bias provided by a motive source. In use, the plunger moves under the bias from a loaded condition to a discharged condition to move the syringe so that the needle extends from a tip at an injection end of the housing and to slide the piston within the barrel to expel the contents of the syringe. The plunger is held in the loaded condition against the bias by a detent extending from the body and which can be selectively released by operation of an actuator when pressure is applied to the tip.

Abstract: Disclosed are apparatus, compositions, and methods for promoting regeneration of tissue on a subject such as a wounded, damaged, or injured appendage, or within a subject such as a wounded, damaged, or injured organ. The disclosed apparatus, composition, and methods include or utilize wearable sleeves and regenerative compositions.

Abstract: A system includes a signal generator, configured to pass a generated signal, which has two different generated frequencies, through a circuit including an intrabody electrode. The system further includes a processor, configured to identify, while the generated signal is passed through the circuit, a derived frequency, which is derived from the generated frequencies, on the circuit, and to generate, in response to identifying the derived frequency, an output indicating a flaw in the electrode. Other embodiments are also described.