Abstract: A method for controlling computerized operations related to a wellbore comprises drilling the wellbore in a subsurface formation with a drill string including a drill bit. The method comprises acquiring a plurality of drilling parameters while drilling the wellbore. The method comprises determining, based on the plurality of drilling parameters, solids properties for solids forming a cutting plug up hole of the drill bit. The method comprises determining a length of the cutting plug based on the solids properties. The method comprises determining a cutting plug friction force based on the cutting plug length and a pressure differential across the cutting plug. The method comprises performing a drilling operation based on the cutting plug friction force.

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.

Abstract: Methods and systems are provided for small molecule analyte detection using digital signals, key encryption, and communications protocols. The methods provide detection of a large numbers of proteins, peptides, RNA molecules, and DNA molecules in a single optical or electrical detection assay within a large dynamic range.

Abstract: Described herein are topical cream formulations that include a C7-20 alkane, a metal chelating agent, and a buffer.

Abstract: The technology relates to partially redundant equipment architectures for vehicles able to operate in an autonomous driving mode. Aspects of the technology employ fallback configurations, such as two or more fallback sensor configurations that provide some minimum amount of field of view (FOV) around the vehicle. For instance, different sensor arrangements are logically associated with different operating domains of the vehicle. Fallback configurations for computing resources and/or power resources are also provided. Each fallback configuration may have different reasons for being triggered, and may result in different types of fallback modes of operation. Triggering conditions may relate, e.g., to a type of failure, fault or other reduction in component capability, the current driving mode, environmental conditions in the vicinity of vehicle or along a planned route, or other factors.

Abstract: This disclosure features herbicidal compositions including one or more indole auxins and methods of making and using the same.

Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for the treatment of cancer characterized by TERT and BRAF mutations. In a specific embodiment, a method for treating a mutant telomerase reverse trancriptase (TERT) enzyme-associated cancer in a subject comprises the step of administering to the subject an anti-cancer agent that inhibits one or more of FOS, GABPB, the formation of the GABPA-GABPB complex or the binding of the GABPA-GABPB complex to a mutant TERT promoter.

Abstract: Described herein are formulations including pharmaceutical agents comprising ester and/or lactone ring structures, and methods of using the same. The invention is also directed to a method and ophthalmic pharmaceutical compositions including solution and semisolid dosage forms (i.e. ophthalmic creams, gels, lotions, serums, and/or ointments) of treating a patient with various ocular diseases including presbyopia and dry eyes. The method comprising instructing a patient to apply one strip of the ophthalmic composition to the eyelids that includes pilocarpine or other active pharmaceutical ingredients containing ester and/or lactone ring structures with and without the buffering system.

Abstract: An ophthalmic therapeutic treatment composition includes a topical cream containing a crosslinked acrylic acid polymer, an acrylamide/sodium acryloyldimethyl taurate copolymer, and an effective amount of an active pharmaceutical ingredient (API) dispersed in the topical cream. The ophthalmic therapeutic treatment composition and API are formulated for topical application and treatment of various disorders such as dry eye, presbyopia, intraocular pressure and blepharitis.

Abstract: A three-phase digital power inverter system controlled by a MCU thereof is provided, wherein during a constant current power source for accelerator control in combination with a three-wire potentiometer are inputted to a MCU for qualification and calculation base on a computation algorithm to obtain data, an accelerator line state and a brake line state are detected simultaneously for whether they are working well individually, so as to effectively prevent any electrical failure due to mechanical failure of the accelerator or the brake or open circuit/short circuit of the accelerator line or the brake line that may cause accident due to out of control of the accelerator or brake respectively. These are the potential risk factors of electric motor vehicles while the present invention can substantially eliminate such potential factor and provide a more reliable performance of electric motor vehicles.

Abstract: An ophthalmic topical cream composition includes a topical cream comprising at least one zwitterion; and an active pharmaceutical ingredient (API) dispersed in the topical cream. The ophthalmic topical cream composition and API are formulated for topical application and treatment of various disorders such as dry eye, presbyopia, intraocular pressure and blepharitis.

Abstract: A three-phase digital power inverter system controlled by a MCU thereof is provided, wherein during a constant current power source for accelerator control in combination with a three-wire potentiometer are inputted to a MCU for qualification and calculation base on a computation algorithm to obtain data, an accelerator line state and a brake line state are detected simultaneously for whether they are working well individually, so as to effectively prevent any electrical failure due to mechanical failure of the accelerator or the brake or open circuit/short circuit of the accelerator line or the brake line that may cause accident due to out of control of the accelerator or brake respectively. These are the potential risk factors of electric motor vehicles while the present invention can substantially eliminate such potential factor and provide a more reliable performance of electric motor vehicles.

Abstract: The present disclosure relates to the technical field of medical instrument and provides a passage establishment device for posterior spinal fusion minimally invasive surgery. The device includes: a tube, an interior of the tube includes a through hole penetrating through both axial ends of the tube, and a wall of the tube includes an opening portion. The tube of the passage establishment device of the present disclosure can be inserted between the vertebral bodies and can also be removed from between the vertebral bodies. The through hole of the tube forms a surgical passage for the fusion device to penetrate, which can safely protect human tissues and is convenient for doctors to perform follow-up operations. The tube can be installed quickly, and thus the operation time is shortened. It is easy to disassemble, clean, and disinfect the tube.

Abstract: The present invention relates to a method of and an apparatus for extending the shelf life of an initiated monomer mixture, the method comprising the prevention of premature free radical polymerisation by introducing oxygen or oxygen-containing gas into a container of the initiated monomer mixture and providing mechanical agitation to the container, wherein said introduction and agitation are performed in a temperature and pressure controlled environment.

Abstract: Described herein are formulations including pharmaceutical agents comprising ester and/or lactone ring structures, and methods of using the same. The invention is also directed to a method and ophthalmic pharmaceutical compositions including solution and semisolid dosage forms (i.e. ophthalmic creams, gels, lotions, serums, and/or ointments) of treating a patient with various ocular diseases including presbyopia and dry eyes. The method comprising instructing a patient to apply one strip of the ophthalmic composition to the eyelids that includes pilocarpine or other active pharmaceutical ingredients containing ester and/or lactone ring structures with and without the buffering system.

Abstract: Disclosed are systems and methods for profiling a plurality of companies. The companies are profiled by receiving HTML files on the world wide web that contain hyperlinks to a domain name of one or more of the plurality of companies; determining an ingress of each of the plurality of companies based on a number of hyperlinks to the domain name of that company in the HTML files; receiving industry categories and industry embedding values for each of the plurality of companies; and designating a first company and a second company of the plurality of companies as similar based at least in part on one or more of the ingress of the first company, the ingress of the second company, a semantic distance between the industry embedding values of the first company and the industry embedding values of the second company, and a number of industry categories common between the first company and the second company.

Abstract: A cradle apparatus detects spatial distances from target objects positioned in adjacency to the cradle apparatus, and communicates with a mobile communications device for selectively powering off/on the visual display of the mobile communications device based on its distance from a target object. The cradle apparatus includes a cradle assembly, at least one distance sensor, and sensor support circuitry. The cradle assembly is configured for cradling the communications device and displaying a visual display of the communications device as cradled by the cradle assembly, optionally at an oblique angle relative to a support surface. Each distance sensor is positioned by the cradle assembly for detecting the relative distance of select objects positioned in adjacency to the visual display. The sensor support circuitry communicates each distance sensor to a switch or circuit board for powering off or powering on the visual display depending on its distance from the target object.

Abstract: A casing or case assembly for a mobile communications device case provides a primary device-receiving body formation. At the posterior portions of the primary device-receiving body formation is an accessory access window. The accessory access window is configured to allow a user to interface a charging device with the mobile communications device as received in the primary device-receiving body formation in anterior adjacency to an optional posterior panel portion. The accessory access window is of sufficient dimension to receive a charger device with a device diameter that fits within the window. A number of accessories, in addition to a charger device, are attachable to the mobile communications device via the accessory access window. Certain exemplary accessories include a cover panel, a wallet accessory, and a vehicular mount mechanism. At least one secondary body formation may be affixed to the primary device-receiving body formation as an outer skin thereof.

Abstract: A cradle apparatus detects spatial distances from target objects positioned in adjacency to the cradle apparatus, and communicates with a mobile communications device for selectively powering off/on the visual display of the mobile communications device based on its distance from a target object. The cradle apparatus includes a cradle assembly, at least one distance sensor, and sensor support circuitry. The cradle assembly is configured for cradling the communications device and displaying a visual display of the communications device as cradled by the cradle assembly, optionally at an oblique angle relative to a support surface. Each distance sensor is positioned by the cradle assembly for detecting the relative distance of select objects positioned in adjacency to the visual display. The sensor support circuitry communicates each distance sensor to a switch or circuit board for powering off or powering on the visual display depending on its distance from the target object.

Abstract: A cradle apparatus cradles a mobile communications device, detects spatial distances from target objects positioned in adjacency to the cradle apparatus, and communicates with the mobile communications device for selectively powering off or powering on the visual display of the mobile communications device based on its distance from a target object. The cradle apparatus includes a cradle assembly, at least one distance sensor, and sensor support circuitry. The cradle assembly is configured for receiving and cradling the communications device and displaying a visual display of the communications device as cradled by the cradle assembly. Each distance sensor is positioned by the cradle assembly for detecting the relative distance of select objects positioned in adjacency to the visual display. The sensor support circuitry communicates each distance sensor to a switch or circuit board for powering off or powering on the visual display depending on its distance from the target object.