Abstract: Provided herein are T cell receptor (TCR) fusion proteins (TFPs) having specificity for more than one tumor cell associated antigen, T cells engineered to express one or more TFP, and methods of use thereof for the treatment of diseases, including cancer.

Abstract: A method of measuring the state or condition of spatially spaced apart machine parts subject to wear and emitting an acoustic signature.

Abstract: Exercise device using rotating hand pedals against a variable resistance for the purpose of exercising the upper-body on an upper-body spinning cycle and incorporating a seating mechanism providing for placement of the operator's body to permit the conditioning of the upper portions of the operator's body including abdominal muscles, hip flexors, back, arms, wrists and hands by pedaling against a resistance to the accompaniment of music or instruction in a class type setting or at home without instruction. The embodiment of the invention allows for adjustment of the resistance to provide both aerobic and anaerobic exercise providing both muscle development and cardio-vascular conditioning. The embodiment of the invention allows the cranks to be rotated in an opposed or reciprocating position similar to conventional bicycles or the cranks can be rotated instantly and freely to be side by side in tandem or any orientation between opposed or tandem.

Abstract: A three-wheeled vehicle having a front body member carrying front wheel seat, hand pedals and leg supports pivotally connected to a rear body member carrying the rear wheels and handlebar. The front body member includes a seat for the operator and pedals to be operated by the rider's hands. The seat, pedals, front wheel and leg supports are maintained in a fixed relationship whereby pivoting of the front frame portion simultaneously pivots the seat, pedals, drive line and front wheel to maintain said fixed relationship while turning and supplying power to the front wheel. A stabilizing dampener between front and rear frame sections provides smooth steering and inhibits undesired, inadvertent, side to side movement of the rider's body and thereby repetitive back and forth turning of the vehicle.