Abstract: Preparation of optionally substituted dihydroisoquinolines. The present invention relates to a process for the preparation of optionally substituted dihydroi-soquinolines of the formula I.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: A production cell includes: at least one robot arranged to handle products; at least one buffer area for intermediate storage of products inside the production cell; a vision system with cameras arranged to determine, based on images from the cameras, the identity and the location of objects in the production cell a plurality of production modules, each production module comprising at least one Hardware Module configured to process products; and a plurality of module attachment locations, each module attachment location being configured to connect with an interface section of a production module through at least a physical connection and a power connection.

Abstract: The present disclosure relates to an ophthalmological laser treatment system for treatment of tissue of an eye comprising an ophthalmological laser treatment device comprising a base station having a treatment laser source configured to generate a treatment laser beam, an arm and an application head, wherein the ophthalmological laser treatment system further comprises an ophthalmological patient interface with a cornea contacting element, and a sclera contacting element, wherein the cornea contacting element and the sclera contacting element define a rotationally asymmetric contact surface configured to contact the eye, wherein the ophthalmological patient interface comprises a through opening, which is configured to enable the treatment laser beam from the application head to pass through the ophthalmological patient interface to penetrate a target volume of tissue of the eye.

Abstract: The present disclosure relates to an ophthalmological patient interface for application to an eye of a person, the ophthalmological patient interface comprising a coupling portion configured to be arranged on an application head of an ophthalmological laser treatment system, wherein the ophthalmological patient interface further comprises an eye fixation portion configured to be arranged on the eye, wherein the eye fixation portion comprises a cornea contacting element, configured to contact at least partially the cornea of the eye, and a sclera contacting element, configured to contact at least partially the sclera of the eye, wherein the cornea contacting element and the sclera contacting element define a rotationally asymmetric contact surface configured to contact the eye.

Abstract: An optoelectronic device includes a substrate carrier and a light source arranged thereon, which has a main radiation direction. A cap with an optical element is arranged above the light source and connected to the substrate carrier. This is arranged in the main radiation direction of the light source. Furthermore, a sensor device is provided, which is designed to emit a wireless signal between the cap and the substrate carrier for detecting damage to the cap. For this purpose, the cap is designed to interact with the emitted wireless signal.

Abstract: Female fiber optic connectors having a weatherproofing collar disposed rearward of a connection port opening that receives a fiber optic plug along with cable assemblies comprising the female fiber optic connector and with methods of making the same. The female fiber optic connectors comprise an actuator such as a rocker latch arm or the like disposed under the weatherproofing collar used for releasing or securing an external fiber optic plug that may be received in the connection port. The weatherproofing collar protects the actuator such as the rocker arm latch and surrounding area from dirt, debris, moisture and the like from ingress into the connector. One or more end caps may be used with the weatherproofing collar. The weatherproofing collar allows for a ruggedized fiber optic connector having a quick connect and release mechanism for the external fiber optic plug connector mated to the female fiber optic connector.

Abstract: Methods, apparatuses, systems, and techniques relate to an extruder unit for producing preforms with a tube-like wall from a polymer melt and an associated extrusion process. The extruder unit has a receptacle for an exchangeable dispensing tool, it furthermore comprises at least two different and alternately usable profiling devices. These profiling devices have outlet-side fastening structures, which correspond in the various profiling devices and form the receptacle for the exchangeable dispensing tool, so that the profiling devices can be connected alternately to the same dispensing tool. In this way, any dispensing tool, depending on the wish of the customer, can be operated with different profiling devices, in particular, on the one hand, to carry out profiling by mandrel body movement or profiling by nozzle body movement.

Abstract: A stator segment of a stator of a generator for a wind turbine has at least one stator laminated core which has at least two stator lamination stacks, wherein adjacent stator lamination stacks of the at least two stator lamination stacks are in each case spaced parallel to one another in an axial direction and forming in each case one stator cooling duct with a stator cooling duct width through which a cooling medium can be guided, in particular in a radial direction. A rotor segment of a rotor for a wind turbine has two or a plurality of magnet units are disposed spaced apart from one another in an axial direction, wherein the magnet units disposed adjacently in the axial direction define a circumferential gap with a gap width for feeding and distributing a cooling medium.

Abstract: Methods, apparatuses, systems, and techniques relate to a tube-forming device for an extruder unit or an extrusion device and a tube-forming process. The tube-forming device comprises at least one shaping sleeve, which is designed to shape a supplied stream of polymer melt from a substantially strand-like cross section into a tubular cross section. The shaping sleeve has a guiding passage embedded in the sleeve wall, such that the guiding passage is a cavity which lies within the sleeve wall and, in the radial direction of the shaping sleeve, is enclosed in a sealed manner with respect to the outer surfaces.

Abstract: A generator module for a vehicle includes a housing with a first conical surface, a rotor assembly with a second conical surface, aligned with the first conical surface, and a spring arranged to push the second conical surface into contact with the first conical surface. In an example embodiment, the first conical surface or the second conical surface includes a plastic surface or a friction paper surface. In an example embodiment, the rotor assembly is axially displaceable within the housing to compress the spring and move the second conical surface away from the first conical surface.

Abstract: A display panel with a first panel side and a second panel side is included in a display device. The display panel displays at least one graphic display object. The display panel includes a first layer which is a pixel matrix and a second layer which includes a plurality of predetermined primary subareas. The display device includes control circuitry to enable the displaying of the graphic display object based on a predefined display alignment in one of a first orientation and a second orientation. The control circuitry adjusts a respective light transmission to a predetermined individual degree for each of the predetermined primary subareas independent of each other based on a physical environment condition.

Abstract: A method for operating an on-board water supply and distribution system of an aircraft for supplying water includes a central tank, consumer assemblies with a supply device and a buffer tank, pump operable in a supply mode and reverse mode, filter device, and high-pressure conduit system. The central tank connects to the pump's upstream side. The conduit system connects the downstream side and consumer assemblies. The pump in supply mode delivers water from the downstream side to the buffer tank. In reverse mode, the pump can convey water from the downstream side to the upstream side. The method includes operating the pump in supply mode so water from the central tank goes to a consumer assembly in a first time interval to fill the buffer tank, and operating the pump in reverse mode in a second time interval so water from the buffer tank passes through the filter device.

Abstract: The invention relates to methods for synthesizing amanitin derivatives having an amino group attached to position 6? of the central tryptophan moiety. The invention furthermore relates to an amanitin derivative having an amino group attached to position 6? of the central tryptophan moiety, conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.

Abstract: In some examples, a screen printing unit includes a screen printing forme cylinder, an impression cylinder, and at least one further rotational transport body. A fixing element of the impression cylinder includes inner and outer contact surfaces for clamping sheets. The inner contact surface has a base radius as a distance from an axis of rotation of the impression cylinder. A cylinder barrel of the impression cylinder has a supporting surface for sheets that includes an impression portion having a constant barrel radius, which extends over at least 170° about the axis of rotation of the impression cylinder and the barrel radius is larger than the base radius. A fixing element of the further rotational transport body includes an inner and an outer contact surface for clamping sheets. The inner contact surface includes the base radius as a distance from an axis of rotation of the further rotational transport body.

Abstract: The present invention relates to a method for producing a multi-layer oral thin film comprising the steps of a) providing a solution, an emulsion, a foam or a suspension comprising at least one first polymer, b) processing the solution, the emulsion, the foam or the suspension from step a) in order to obtain a polymer film, c) applying a powder comprising at least one second substance, which preferably differs from the first polymer, to the polymer film, and d) forming a composite between the polymer film and the powder applied in step c), to a multi-layer oral thin film obtainable by this method, and to the use of a multi-layer oral thin film obtainable by this method as a medicament.

Abstract: The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.

Abstract: The present invention relates to a multi-layer thin film comprising at least two layers arranged one on top of the other which each comprise at least one polymer, these at least two layers being connected to one another by at least one stitched seam using at least one thread, and to a method for producing such a thin film and to the use thereof as a medicament.

Abstract: [1-Pheny1)-5-(heteroaryl)-1H-pyrazol-3-yl)oxy] acetic acid derivatives and salts thereof, crop protection compositions comprising them, processes for preparing them, use thereof and plant protection compositions. The present invention relates to crop protection compounds and to compositions which comprise specific compounds as safeners for reducing phytotoxic effects of agrochemicals, especially herbicides. The invention relates more particularly to certain [1-(phenyl)-5-(heteroaryl)-1H-pyrazol-3-yl)oxy]acetic acid derivatives of the general formula (I) and their salts, to processes for preparing them and to their use as plant protection compounds (safeners).

Abstract: A method for operating an on-board water supply and distribution system of an aircraft for supplying water includes a central water tank, first consumer assemblies with buffer tanks each including a heater to heat up water in the buffer tank to a disinfection temperature, pump having upstream and downstream sides to operate in supply and reverse modes, and high-pressure conduit system. The central water tank connects to the pump's upstream side. The conduit system connects the downstream side with a first consumer assembly. The method includes operating the pump in supply mode where water from the central tank goes to a first consumer assembly to fill a buffer tank, operating a buffer tank heater so water heats to a predetermined disinfection temperature, and operating the pump in reverse mode so heated water passes through a part of the conduit system and the upstream side of the pump.