Patents by Inventor Michael Manley

Michael Manley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240166994
    Abstract: Compositions comprising a population of oligodendrocyte progenitor cells (OPCs), as well as methods of making and using the same, are provided. In one aspect, a container comprising a composition, where the composition comprises a population of cells comprising a plurality of OPCs, and where the population of cells comprises less than 15% undesirable cell types is provided. In another aspect, the population of cells comprises less than 15% undesirable epithelial lineage cells. In yet another aspect, the population of cells comprises less than 2% K7 positive cells. In an aspect, a population of cells comprising a plurality of oligodendrocyte progenitor cells is capable of forming less than one epithelial cyst per 100,000 cells in a cyst assay is provided. An even further aspect of the present disclosure is a container comprising a composition, where the composition comprising a plurality of oligodendrocyte progenitor cells is useful in treating treat stroke, spinal cord injury, and multiple sclerosis.
    Type: Application
    Filed: January 26, 2024
    Publication date: May 23, 2024
    Inventors: Erik Michael WHITELEY, Uzma SHOUKAT-MUMTAZ, Rashi SRIVASTAVA, Nathan Charles MANLEY, Casey Christopher CASE
  • Patent number: 11921041
    Abstract: Exemplified methods and systems facilitate presentation of data derived from measurements of endotoxins in fluid samples. In particular, the exemplified methods and systems facilitate presentation of such measurements in a graphical user interface and/or in a report for endotoxin concentrations in a fluid sample. The presentation facilitates a unified and intuitive graphic visualization that are presented within a single interactive interface and/or report.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: March 5, 2024
    Assignee: BL Technologies, Inc.
    Inventors: Sukmi Ledru, Krzysztof Franaszczuk, Jesse Manley, David Kremer, Vamsi Panuganti, Jeremiah Teague, Yan Le, Michael Scaer
  • Patent number: 11920155
    Abstract: Compositions comprising a population of oligodendrocyte progenitor cells (OPCs), as well as methods of making and using the same, are provided. In one aspect, a container comprising a composition, where the composition comprises a population of cells comprising a plurality of OPCs, and where the population of cells comprises less than 15% undesirable cell types is provided. In another aspect, the population of cells comprises less than 15% undesirable epithelial lineage cells. In yet another aspect, the population of cells comprises less than 2% K7 positive cells. In an aspect, a population of cells comprising a plurality of oligodendrocyte progenitor cells is capable of forming less than one epithelial cyst per 100,000 cells in a cyst assay is provided. An even further aspect of the present disclosure is a container comprising a composition, where the composition comprising a plurality of oligodendrocyte progenitor cells is useful in treating treat stroke, spinal cord injury, and multiple sclerosis.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: March 5, 2024
    Assignee: ASTERIAS BIOTHERAPEUTICS, INC.
    Inventors: Erik Michael Whiteley, Uzma Shoukat-Mumtaz, Rashi Srivastava, Nathan Charles Manley, Casey Christopher Case
  • Publication number: 20070220737
    Abstract: A chip has formed thereon integrated circuit elements, which include a main circuit and an associated non volatile memory structure. A test result associated with prior testing of a function of the main circuit is stored in the non volatile memory structure. Additional apparatus and methods are disclosed.
    Type: Application
    Filed: September 6, 2006
    Publication date: September 27, 2007
    Inventors: Anthony Stoughton, Michael Manley, Christopher Segura, Ronald Lee Koepp, Ernest Allen, Andrew E. Horch, Robert C. Collins
  • Patent number: 6219987
    Abstract: An arrangement of endcaps particularly formed and arranged for use in connection with composite deck beams particularly adapted to use on rail car running boards but is also suitable to other beam type decks such as those used on semi-trailers, in marine applications or as industrial catwalks. The endcaps close the ends of fiberglass reinforced plastic running boards, complementing the strength, economy and durability of such materials.
    Type: Grant
    Filed: May 26, 1999
    Date of Patent: April 24, 2001
    Assignee: Holland Company
    Inventors: Robert S. Trent, R. Michael Manley
  • Patent number: 6206214
    Abstract: A railcar coupler carrier wear plate is formed in an “L” shaped section for ease of insertion and replacement in a coupler carrier and for efficient manufacture, the coupler carrier wear plate being retained in the coupler carrier with a bracket arrangement that can be readily affixed to the coupler carrier as by welding and which can also be adapted to protect the coupler carrier wear plate in the event of a coupler override.
    Type: Grant
    Filed: August 20, 1998
    Date of Patent: March 27, 2001
    Assignee: Holland Company
    Inventors: Todd J. de Koning, R. Michael Manley
  • Patent number: 6068146
    Abstract: A self-lubricating plastic coupler carrier wear plate is formed in a generally T-shape having an outer flange and an inner flange conforming to said T-shape, said web being notched proximate said inner flange for adequate clearance with railcar draft gear.
    Type: Grant
    Filed: October 14, 1998
    Date of Patent: May 30, 2000
    Assignee: Holland Company
    Inventors: Robert S. Trent, R. Michael Manley, Todd J. De Koning
  • Patent number: 5948278
    Abstract: A method for enriching rare cell populations from a whole blood sample by separating rare cell fractions from whole blood sample according to the relative charge density and/or the relative binding affinity for a leukocyte depletion solid phase matrix is described. The enrichment method may be operated stand alone, or as a pre or post-processing step in conjunction with a charge-flow separation method.
    Type: Grant
    Filed: October 10, 1997
    Date of Patent: September 7, 1999
    Assignee: BioSeparations, Inc.
    Inventors: David W. Sammons, Michael Manley, Joseph G. Utermohlen, Garland E. Twitty
  • Patent number: 5676849
    Abstract: A method for enriching rare cell populations from a whole blood sample by separating rare cell fractions from whole according to the relative charge density and/or the relative binding affinity for a leukocyte depletion solid phase matrix. The enrichment method may be operated stand alone, or as a pre or post-processing step in conjunction with a charge-flow separation method.
    Type: Grant
    Filed: March 8, 1995
    Date of Patent: October 14, 1997
    Assignee: BioSeparations, Inc.
    Inventors: David W. Sammons, Michael Manley, Joseph G. Utermohlen, Garland E. Twitty
  • Patent number: 5176268
    Abstract: A railroad car having an improved draft gear assembly including a center sill structure terminating at one end in a draft center sill section having a yoke mounted therewith. The yoke includes first and second yoke members extending longitudinally. An interlocking coupler member including a head portion and a shank portion is mounted with the yoke. A connector assembly holds the interlocking coupler member in position in the yoke. The interlocking coupler member includes a rear butt portion positioned internally of the connector assembly for engaging a follower block mounted substantially between the first and second yoke members. A resilient member is mounted between the follower block assembly and the end of the yoke.
    Type: Grant
    Filed: June 11, 1991
    Date of Patent: January 5, 1993
    Assignee: Houston Industries Incorporated
    Inventor: R. Michael Manley