Abstract: Provided herein are methods of treating and/or managing cancers, which comprise administering to a patient Compound A. Provided herein are also methods of treating and/or managing cancers, which comprise administering to a patient Compound A in combination with nivolumab. Additionally, provided herein are methods of treating and/or managing cancers, which comprise administering to a patient Compound A in combination with chemotherapy.

Abstract: The present invention generally relates to a multipurpose tool for angling. In particular, the invention relates to a threading device for threading or affixing, respectively, a fishing hook to a fishing line. Furthermore, the Invention relates to a method of manufacturing the threading device for threading or affixing, respectively, a fishing hook to a fishing line, the use of the device as well as a threading set. The present invention further relates to a multipurpose tool for stunning and eviscerating fish. In particular, the invention is concerned with a multipurpose tool of the type of a pocket knife, which is suitable for stunning and eviscerating fish and whose posterior end is formed as a stunning tool.

Abstract: The present invention generally relates to a multipurpose tool for angling. In particular, the invention relates to a threading device for threading or affixing, respectively, a fishing hook to a fishing line. Furthermore, the Invention relates to a method of manufacturing the threading device for threading or affixing, respectively, a fishing hook to a fishing line, the use of the device as well as a threading set. The present invention further relates to a multipurpose tool for stunning and eviscerating fish. In particular, the invention is concerned with a multipurpose tool of the type of a pocket knife, which is suitable for stunning and eviscerating fish and whose posterior end is formed as a stunning tool.