Patents by Inventor Michael MARKEY

Michael MARKEY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230373904
    Abstract: Various polymorphic forms of RAD1901-2HCl, including three crystalline and amorphous forms, are prepared and characterized. Uses of the various polymorphic forms of RAD1901-2HCl for cancer treatment are also disclosed.
    Type: Application
    Filed: May 31, 2023
    Publication date: November 23, 2023
    Inventors: Michael Paul Cruskie, JR., Joshua Kyle Bolger, Jonathan Blake McKenzie, Pratik Sheth, Richard Edwards, Alex Eberlin, Michael Markey
  • Patent number: 11708318
    Abstract: Various polymorphic forms of RAD1901-2HCl, including three crystalline and amorphous forms, are prepared and characterized. Uses of the various polymorphic forms of RAD1901-2HCl for cancer treatment are also disclosed.
    Type: Grant
    Filed: September 14, 2021
    Date of Patent: July 25, 2023
    Assignee: RADIUS PHARMACEUTICALS, INC.
    Inventors: Michael Paul Cruskie, Jr., Joshua Kyle Bolger, Jonathan Blake McKenzie, Pratik Sheth, Richard Edwards, Alex Eberlin, Michael Markey
  • Patent number: 11643385
    Abstract: A solid form of RAD1901-2HCl having an X-ray powder diffraction pattern comprising a peak, in terms of 2-theta, at 11.53 degrees 2?±0.2 degrees 2?, and compositions, methods, and processes thereof.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: May 9, 2023
    Assignee: Radius Pharmaceuticals, Inc.
    Inventors: Michael Paul Cruskie, Joshua Kyle Bolger, Jonathan Blake McKenzie, Pratik Sheth, Richard Edwards, Alex Eberlin, Michael Markey
  • Publication number: 20220162233
    Abstract: Useful processes of preparation and intermediates useful for the preparation of Compound 1, a selective estrogen receptor alpha (ER?) modulator/degrader (SERM/SERD), having utility for the treatment of ER+ cancers including breast cancer are described.
    Type: Application
    Filed: February 11, 2020
    Publication date: May 26, 2022
    Inventor: Michael MARKEY
  • Publication number: 20220048848
    Abstract: Various polymorphic forms of RAD1901-2HCl, including three crystalline and amorphous forms, are prepared and characterized. Uses of the various polymorphic forms of RAD1901-2HCl for cancer treatment are also disclosed.
    Type: Application
    Filed: September 14, 2021
    Publication date: February 17, 2022
    Inventors: Michael Paul Cruskie, JR., Joshua Kyle Bolger, Jonathan Blake McKenzie, Pratik Sheth, Richard Edwards, Alex Eberlin, Michael Markey
  • Patent number: 11148996
    Abstract: Various polymorphic forms of RAD1901-2HCl, including three crystalline and amorphous forms, are prepared and characterized. Uses of the various polymorphic forms of RAD1901-2HCl for cancer treatment are also disclosed.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: October 19, 2021
    Assignee: Radius Pharmaceuticals, Inc.
    Inventors: Michael Paul Cruskie, Jr., Joshua Kyle Bolger, Jonathan Blake McKenzie, Pratik Sheth, Richard Edwards, Alex Eberlin, Michael Markey
  • Publication number: 20210269389
    Abstract: Various polymorphic forms of RAD1901-2HCl, including four crystalline and amorphous forms, are prepared and characterized. Uses of the various polymorphic forms of RAD1901-2HCl for cancer treatment are also disclosed.
    Type: Application
    Filed: July 3, 2019
    Publication date: September 2, 2021
    Inventors: Michael Paul CRUSKIE, Joshua Kyle BOLGER, Jonathan Blake MCKENZIE, Pratik SHETH, Richard EDWARDS, Alex EBERLIN, Michael MARKEY
  • Publication number: 20200361853
    Abstract: Various polymorphic forms of RAD1901-2HCl, including three crystalline and amorphous forms, are prepared and characterized. Uses of the various polymorphic forms of RAD1901-2HCl for cancer treatment are also disclosed.
    Type: Application
    Filed: July 6, 2020
    Publication date: November 19, 2020
    Inventors: Michael Paul Cruskie, JR., Joshua Kyle Bolger, Jonathan Blake McKenzie, Pratik Sheth, Richard Edwards, Alex Eberlin, Michael Markey
  • Patent number: 10745343
    Abstract: Various polymorphic forms of RAD1901-2HCl, including three crystalline and amorphous forms, are prepared and characterized. Uses of the various polymorphic forms of RAD1901-2HCl for cancer treatment are also disclosed.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: August 18, 2020
    Assignee: RADIUS PHARMACEUTICALS, INC.
    Inventors: Michael Paul Cruskie, Jr., Joshua Kyle Bolger, Jonathan Blake McKenzie, Pratik Sheth, Richard Edwards, Alex Eberlin, Michael Markey
  • Publication number: 20200062694
    Abstract: Various polymorphic forms of RAD1901-2HCl, including three crystalline and amorphous forms, are prepared and characterized. Uses of the various polymorphic forms of RAD1901-2HCl for cancer treatment are also disclosed.
    Type: Application
    Filed: September 13, 2019
    Publication date: February 27, 2020
    Inventors: Michael Paul Cruskie, JR., Joshua Kyle Bolger, Jonathan Blake McKenzie, Pratik Sheth, Richard Edwards, Alex Eberlin, Michael Markey
  • Patent number: 10385008
    Abstract: Various polymorphic forms of RAD1901-2HCl, including three crystalline and amorphous forms, are prepared and characterized. Uses of the various polymorphic forms of RAD1901-2HCl for cancer treatment are also disclosed.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: August 20, 2019
    Assignee: Radius Pharmaceuticals, Inc.
    Inventors: Michael Paul Cruskie, Jr., Joshua Kyle Bolger, Jonathan Blake McKenzie, Pratik Sheth, Richard Edwards, Alex Eberlin, Michael Markey
  • Publication number: 20180186726
    Abstract: Various polymorphic forms of RAD1901-2HCl, including three crystalline and amorphous forms, are prepared and characterized. Uses of the various polymorphic forms of RAD1901-2HCl for cancer treatment are also disclosed.
    Type: Application
    Filed: January 5, 2018
    Publication date: July 5, 2018
    Inventors: Michael Paul CRUSKIE, JR., Joshua Kyle BOLGER, Jonathan Blake MCKENZIE, Pratik SHETH, Richard EDWARDS, Alex EBERLIN, Michael MARKEY
  • Patent number: 10012694
    Abstract: A technique for testing an electronic UUT by a test apparatus includes obtaining multiple DFTs of a test signal received from the UUT with the test apparatus configured differently for obtaining each DFT. The resulting DFTs include both valid content representing the test signal and invalid content introduced by the test apparatus. The improved technique suppresses the invalid content by generating a corrected DFT, which provides minimum magnitude values for corresponding frequencies relative to the test signal across the multiple DFTs.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: July 3, 2018
    Assignee: AAI Corporation
    Inventors: James Joseph Jaklitsch, Jay Michael Markey
  • Publication number: 20170315173
    Abstract: A technique for testing an electronic UUT by a test apparatus includes obtaining multiple DFTs of a test signal received from the UUT with the test apparatus configured differently for obtaining each DFT. The resulting DFTs include both valid content representing the test signal and invalid content introduced by the test apparatus. The improved technique suppresses the invalid content by generating a corrected DFT, which provides minimum magnitude values for corresponding frequencies relative to the test signal across the multiple DFTs.
    Type: Application
    Filed: April 27, 2016
    Publication date: November 2, 2017
    Inventors: James Joseph Jaklitsch, Jay Michael Markey
  • Patent number: 5953123
    Abstract: This invention relates to an improved method and mechanism by which to align closed loop interferometric fiber optic gyroscopes. Such method and means includes aligning the gyroscope periodically at fixed time intervals; providing multiplexed control of the gyroscope's internal phase rebalance control loop and gain scaling control loop, enabling one or the other, but never both simultaneously, and thereby eliminate acceleration-dependent errors; eliminating the 1 LSB phase discontinuity produced during each roll-over in the gyroscope by adding an offset to the output ramp produced by said serrodyne ramp generator; and providing a means and method to align the phase-rebalance loop gain for each production unit.
    Type: Grant
    Filed: December 31, 1997
    Date of Patent: September 14, 1999
    Assignee: AAI Corporation
    Inventors: James Joseph Jaklitsch, Jay Michael Markey
  • Patent number: 5914781
    Abstract: This invention relates to an improved method and mechanism for eliminating acceleration-dependent errors and loop interaction effects in gain-stabilized, closed-loop, interferometric fiber optic gyroscopes. Such method and mechanism include enabling the modulation gain accumulator and disabling the rate accumulator on every occurrence of ramp flyback if the gyroscope is operating below a certain velocity threshold and enabling the modulation gain accumulator and disabling the rate accumulator on one out of every N occurrences of ramp flyback if the gyroscope is operating above a certain velocity threshold. Such method and mechanism also includes use of proportional circuitry to scale the magnitude of the bias modulation component to be a percentage of the serrodyne ramp voltage and the DC component to be zero volts.
    Type: Grant
    Filed: December 31, 1997
    Date of Patent: June 22, 1999
    Assignee: AAI Corporation
    Inventors: James Joseph Jaklitsch, Jay Michael Markey