Abstract: A package that is configured to store and dispense fluids. The package includes a container and a dosing dispenser for closing an opening to the container. The dosing dispenser includes a closure removably coupled to the container and an anti-suction valve fixed to the container that is configured to minimize formation of a complete seal between a user's mouth and an upper surface of the anti-suction valve so that sufficient suction to remove fluid from the container is blocked.

Abstract: An electric machine with a low profile retention assembly for retention of a stator core is disclosed. A first housing houses the stator core. The first housing has an axial end face with a circumferentially extending, shaped profile having recessed portions that project axially inward alternating with non-recessed portions. A portion of the stator core extends axially out from the recessed portions. A core retention spring is disposed circumferentially at the axial end face of the first housing. The core retention spring has direct contact with the portion of the stator core that extends axially out from the recessed portions of the first housing and the shaped profile of the housing. The core retention spring pushes against the portion of the stator core that extends that extends axially out from the first housing, imparting one or more of an axial load and radial load into the stator core.

Abstract: Proposed is a system and method for measuring relative risk measurands of living individuals. The relative risk measurands provides a measure for the frequency of occurrences of specific medical events having impacting consequences in specified ranges to the living individual within a defined cohort of living individuals relative to a randomized cohort of living individuals. The system provides automation of the risk assessment and measuring process with a high efficiency and accuracy.

Abstract: A compound of formula (I) or formula (II) including tautomeric or stereochemically isomeric forms thereof, wherein: R1 represents C1-20 alkyl, C2-20 alkenyl, C6-20 aryl, or C4-20 heterocyclyl, each optionally substituted with one or more Y groups, R2a to R2l each independently represents H, C1-10 alkyl, C2-10 alkenyl, C6-12 aryl, or C4-12 heterocyclyl, each optionally substituted with one or more Y groups, R3 represents H, C1-10 alkyl, C2-10 alkenyl, C6-12 aryl, or C4-12 heterocyclyl, each optionally substituted with one or more Y groups, X represents NH, S or O, each Y independently represents cyano, halogen, N3, —C(O)RZ, —C(0)0Rz, —0C(0)Rz, —C(0)NHZ, —NHC(O)Rz, —NHC(0)NHRZ, —NHC(NH)NHRZ, —NCH(0)0Rz, -0C(0)NHRz, -0S(0)2RZ, —S(0)2NHRZ, —NHS(0)2RZ, —SRZ, —NRZZ or —ORz and each Rz independently represents H, C1-10 alkyl, C2-10 alkenyl, C6-10 aryl, or C4-10 heterocyclyl; or an N-oxide thereof or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof; and wherein formula (I) e

Abstract: Intra-cardiac voltage data display systems display a plurality of data sets derived at least from intra-cardiac voltage data sampled by an electrode. In some embodiments, at least some of the data sets are derived from a portion of the intra-cardiac voltage data that excludes an excludable portion of the intra-cardiac voltage data having a relationship with an occurrence of a particular cardiac event to facilitate identification of the existence of a transmural lesion in tissue adjacent the electrode. In some embodiments, the particular cardiac event is the occurrence of an R wave in the cardiac cycle, and the excludable portion is a V wave in the cardiac cycle.

Abstract: A delivery system may include a pallet wrapper system having a turntable, a camera directed toward an area above the turntable, and a stretch wrap dispenser adjacent the turntable. A computer receives images from the camera of multiple sides of a pallet loaded with packages on the turntable. The computer stitches images from different sides of the stack of packages that correspond to the same package. At least one machine learning model may be used to infer SKUs of each package. Optical character recognition may be performed in parallel on the images. The determination of the SKU of each package may be based upon the inferred SKUs and on the OCR.

Abstract: A holder is described. The holder is for a sample vial and includes a base and a cap, where the holder and cap include one or more materials that are opaque or optically black. The holder includes an interior space for placement of the vial in a light-tight environment, where the holder cap includes an opening for insertion of a probe therethrough and into the sample vial. The disclosure also includes systems and methods using the holder.

Abstract: A method can include establishing, by a computing system, a secure electronic network connection to an electronic agent running configured to access the dataset to dynamically generate the metadata related to the dataset on a client computing system. A method can include receiving, by the computing system, from the electronic agent via the secure electronic network connection, metadata related to a dataset, the metadata comprising a plurality of attributes of the dataset and a summary of the dataset. A method can include applying a valuation model to the metadata to determine an estimated value of the dataset, the valuation model comprising a machine learning model trained using marketplace data comprising sales prices and attributes of one or more datasets, wherein the model is trained to output the sales prices of the one or more datasets. A method can include determining, an estimated value of the dataset.

Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Abstract: The disclosed technology generally relates dielectric materials and methods of forming the same, and more particularly to a combination of co-fireable dielectric materials that can be attached to each other without the use of adhesives. In an aspect, a composite article comprises a magnetic portion comprising a nickel zinc ferrite. The composite article additionally comprises a non-magnetic portion contacting the magnetic portion, the non-magnetic portion comprising a spinel-structured oxide comprising Mg2-xAl2xTi1-xO4 and having a dielectric constant between about 7 and 14, wherein 0<x?1.

Abstract: An approach for facilitating mechanical and electrical connection of electric machines and electrical components in an electrical system using connectors with quick connect/disconnect electrical connectors is disclosed. Each quick connect/disconnect electrical connector can be placed on the end of an electrical power distribution cable that connects with an electric machine or electrical component. The electric machines and electrical components and the electrical power distribution cables can have hollow coolant passages formed therein to receive cooling fluid from a cooling device for direct cooling of the electric machines, electrical components and the electrical power distribution cables.

Abstract: Audio signals are obtained and filtered. First and second audio processing tools are selected, and priorities associated with the first and second audio processing tools are assigned. In response to a higher priority associated with the first audio processing tool, the audio signal is encoded using the first audio processing tool. A multi-channel audio format for decoding the encoded may be selected and the encoded audio signal is decoded to the selected multi-channel audio format. Further, metadata associated with audio objects may be obtained. A gain level for each audio object may be determined based on the metadata and the gain level may be adjusted using the second audio processing tool. Another multi-channel audio format may be selected, and the gain level adjusted audio signal may be encoded based on the other selected multi-channel audio format. The gain level adjusted audio signal is output to be rendered via playback devices.

Abstract: Disclosed herein are embodiments of low temperature co-fireable barium tungstate materials which can be used in combination with high dielectric materials, such as nickel zinc ferrite, to form composite structures, in particular for isolators and circulators for radiofrequency components. Embodiments of the material can include flux, such as bismuth vanadate, to reduce co-firing temperatures.

Abstract: A method monitors the state of a device having a first drive cylinder for receiving hydraulic fluid and a first drive piston which is movably arranged in the first drive cylinder. The method determines a speed of the first drive piston, establishes a difference between the determined speed of the first drive piston and an expected speed of the first drive piston, and determines a faulty state as a function of the difference established between the determined speed of the first drive piston and the expected speed of the first drive piston.

Abstract: The present invention discloses a process for engineering a host cell comprising the steps of; a) integrating a first polynucleotide cassette including a first selection marker flanked by a first pair of recombination sites; b) removing the first selection marker by the action of a recombinase which recognises the first pair of recombination sites; c) integrating a second polynucleotide cassette including a second selection marker flanked by a second pair of recombination sites; and d) removing the second selection marker by the action of a recombinase which recognises the second pair of recombination sites. Also disclosed is a host cell genome polynucleotide comprising a first recombinantly engineered region and a second recombinantly engineered region, wherein a first single recombination site is adjacent to the first recombinantly engineered region, and a second single recombination site is adjacent to the second recombinantly engineered region.

Abstract: A device for sealing an aperture in a tissue includes: a foot including a distal portion configured to be disposed distal to the tissue when the device is implanted in a position to seal the aperture; and a flexible wing positionable against a distal surface of the tissue adjacent the aperture such that the flexible wing is disposed between the distal portion of the foot and the distal surface adjacent the aperture.

Abstract: A system may include a laser source, an acousto-optic modulator (AOM) coupled to the laser source, an atom trap, and at least one optical medium coupled between the AOM and the atom trap. Furthermore, at least one piezoelectric transducer may be coupled to the at least one optical medium, and a beam polarization controller may be coupled to the at least one piezoelectric transducer.

Abstract: A panel mounting system and associated components and methods. The panel mounting system includes a panel system comprising a plurality of panels. The panel mounting system also includes a plurality of panel accessories selectively mountable on the panel system at desired locations. The panel accessories can include a panel mount and an object support. The panel mounting system provides several advantages compared to conventional peg board mounting systems.

Abstract: A circuit assembly may include a substrate and a pattern of contact points formed from deformable conductive material supported by the substrate. The assembly may further include an electric component supported by the substrate and having terminals arranged in a pattern corresponding to the pattern of contacts points. The one or more of the terminals of the electric component may contact one or more of the corresponding contact points to form one or more electrical connections between the electric component and the contact points.