Patents by Inventor Michael Mendez

Michael Mendez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11920166
    Abstract: Described herein are variant, novel cannabinoid synthases, nucleic acids encoding same, and various uses thereof.
    Type: Grant
    Filed: July 20, 2022
    Date of Patent: March 5, 2024
    Assignee: RENEW BIOPHARMA, INC.
    Inventors: Kyle Botsch, Craig Behnke, Karla Gonzalez, Matthew Saunders, Michael Mendez
  • Publication number: 20230203455
    Abstract: Described herein are variant, novel cannabinoid synthases, nucleic acids encoding same, and various uses thereof.
    Type: Application
    Filed: July 20, 2022
    Publication date: June 29, 2023
    Inventors: Kyle BOTSCH, Craig BEHNKE, Karla GONZALEZ, Matthew SAUNDERS, Michael MENDEZ
  • Publication number: 20230029027
    Abstract: The disclosure relates to the biosynthesis of cannabinoids and related prenylated phenolic compounds using recombinant enzymes. In particular, the disclosure provides recombinant prenyltransferase enzymes engineered to produce a greater amount of a desired product, or to have a greater ability to catalyze a reaction using a desired substrate, as compared to the wild type prenyltransferase. The disclosure also provides methods of preparing such recombinant enzymes; as well as methods of use thereof in improving the biosynthesis of cannabinoids and related prenylated phenolic compounds.
    Type: Application
    Filed: April 13, 2020
    Publication date: January 26, 2023
    Inventors: Michael MENDEZ, Joseph NOEL, Michael BURKART, Jeremy LANOISELEE, Kyle BOTSCH, Matthew SAUNDERS
  • Publication number: 20210301267
    Abstract: The disclosure relates to the biosynthesis of cannabinoids and related prenylated phenolic compounds using recombinant enzymes. In particular, the disclosure provides recombinant mutant ORF2 enzymes engineered to produce a greater amount of a desired product, or to have a greater ability to catalyze a reaction using a desired substrate, as compared to WT ORF2. The disclosure also provides methods of preparing such ORF2 mutant enzymes; as well as methods of use thereof in improving the biosynthesis of cannabinoids and related prenylated phenolic compounds.
    Type: Application
    Filed: October 27, 2020
    Publication date: September 30, 2021
    Inventors: Michael MENDEZ, Joseph NOEL, Michael BURKART, Jeremy LANOISELEE, Kyle BOTSCH, Matthew SAUNDERS
  • Publication number: 20210238561
    Abstract: Described herein are variant, novel cannabinoid synthases, nucleic acids encoding same, and various uses thereof.
    Type: Application
    Filed: April 23, 2019
    Publication date: August 5, 2021
    Inventors: Kyle BOTSCH, Craig BEHNKE, Karla GONZALEZ, Matthew SAUNDERS, Michael MENDEZ
  • Patent number: 10894952
    Abstract: The disclosure relates to the biosynthesis of cannabinoids and related prenylated phenolic compounds using recombinant enzymes. In particular, the disclosure provides recombinant mutant ORF2 enzymes engineered to produce a greater amount of a desired product, or to have a greater ability to catalyze a reaction using a desired substrate, as compared to WT ORF2. The disclosure also provides methods of preparing such ORF2 mutant enzymes; as well as methods of use thereof in improving the biosynthesis of cannabinoids and related prenylated phenolic compounds.
    Type: Grant
    Filed: November 13, 2019
    Date of Patent: January 19, 2021
    Assignee: RENEW BIOPHARMA, INC.
    Inventors: Michael Mendez, Joseph Noel, Michael Burkart, Jeremy Lanoiselee, Kyle Botsch, Matthew Saunders
  • Publication number: 20200123511
    Abstract: The disclosure relates to the biosynthesis of cannabinoids and related prenylated phenolic compounds using recombinant enzymes. In particular, the disclosure provides recombinant mutant ORF2 enzymes engineered to produce a greater amount of a desired product, or to have a greater ability to catalyze a reaction using a desired substrate, as compared to WT ORF2. The disclosure also provides methods of preparing such ORF2 mutant enzymes; as well as methods of use thereof in improving the biosynthesis of cannabinoids and related prenylated phenolic compounds.
    Type: Application
    Filed: November 13, 2019
    Publication date: April 23, 2020
    Inventors: Michael MENDEZ, Joseph NOEL, Michael BURKART, Jeremy LANOISELEE, Kyle BOTSCH, Matthew SAUNDERS
  • Publication number: 20180251800
    Abstract: The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.
    Type: Application
    Filed: January 29, 2018
    Publication date: September 6, 2018
    Inventors: Joshua A. Silverman, Sol M. Resnick, Michael Mendez, Renee M. Saville, Sungwon Lee, Luan Nguyen
  • Patent number: 9970032
    Abstract: The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: May 15, 2018
    Assignee: Calysta, Inc.
    Inventors: Joshua A. Silverman, Sol M. Resnick, Michael Mendez
  • Publication number: 20170009250
    Abstract: The present disclosure relates to methods of expressing therapeutic proteins in photosynthetic organisms and the therapeutic proteins produced by the methods. The therapeutic proteins include high-mobility group box 1 (HMGB1) protein, fibronectin domain (10) (10FN3), fibronectin domain (14) (14FN3), interferon beta (IFN?), proinsulin and vascular endothelial growth factor (VEGF). The photosynthetic organisms include prokaryotes such as cyanobacteria and eukaryotes such as alga and plants. Transformation of eukaryotes is preferably the plastid genome, more preferably the chloroplast genome.
    Type: Application
    Filed: January 28, 2016
    Publication date: January 12, 2017
    Applicants: Sapphire Energy, Inc., The Scripps Research Institute
    Inventors: Beth A. Rasala, Rosa M. F. Cardoso, Machiko Muto, Stephen P. Mayfield, Philip A. Lee, Craig A. Behnke, Michael Mendez
  • Publication number: 20160289714
    Abstract: The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.
    Type: Application
    Filed: June 20, 2016
    Publication date: October 6, 2016
    Inventors: Joshua A. Silverman, Sol M. Resnick, Michael Mendez, Renee M. Saville, Sungwon Lee, Luan Nguyen
  • Publication number: 20160289782
    Abstract: The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.
    Type: Application
    Filed: June 20, 2016
    Publication date: October 6, 2016
    Inventors: Joshua A. Silverman, Sol M. Resnick, Michael Mendez, Renee M. Saville, Sungwon Lee, Luan Nguyen
  • Patent number: 9428779
    Abstract: The present disclosure provides novel proteins that when over expressed in algae result in an increase or change in fatty acid and/or glycerol lipid production and/or accumulation, without a substantial decrease in the growth rate of the alga or the break down of algal components, such as chlorophyll. The present disclosure also describes methods of using the novel proteins to increase or change the production and/or accumulation of fatty acids and/or glycerol lipids in algae. In addition, these proteins are useful tools in obtaining information about the fatty acid and triacyglyceride (TAG) synthetic pathways in algae.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: August 30, 2016
    Assignee: SAPPHIRE ENERGY, INC.
    Inventors: Christopher Yohn, April Brand, Michael Mendez, Craig A. Behnke
  • Patent number: 9410168
    Abstract: The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: August 9, 2016
    Assignee: Calysta, Inc.
    Inventors: Joshua A. Silverman, Sol M. Resnick, Michael Mendez, Renee M. Saville, Sungwon Lee, Luan Nguyen
  • Patent number: 9371549
    Abstract: The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: June 21, 2016
    Assignee: Calysta, Inc.
    Inventors: Joshua Silverman, Sol M. Resnick, Michael Mendez, Renee Saville, Sungwon Lee, Luan Nguyen
  • Publication number: 20160040198
    Abstract: The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.
    Type: Application
    Filed: October 19, 2015
    Publication date: February 11, 2016
    Inventors: Joshua A. Silverman, Sol M. Resnick, Michael Mendez
  • Publication number: 20150353971
    Abstract: The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.
    Type: Application
    Filed: July 30, 2015
    Publication date: December 10, 2015
    Inventors: Joshua A. Silverman, Sol M. Resnick, Michael Mendez, Renee M. Saville, Sungwon Lee, Luan Nguyen
  • Publication number: 20150218508
    Abstract: The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.
    Type: Application
    Filed: March 27, 2015
    Publication date: August 6, 2015
    Inventors: Joshua A. Silverman, Sol M. Resnick, Michael Mendez, Renee M. Saville, Sungwon Lee, Luan Nguyen
  • Publication number: 20150132829
    Abstract: The present invention provides compositions and methods for producing flocculation moieties in photosynthetic organisms. The photosynthetic organisms are genetically modified to effect production, secretion, or both, of the flocculation moieties. Also provided are methods of flocculating organisms.
    Type: Application
    Filed: January 23, 2015
    Publication date: May 14, 2015
    Applicant: SAPPHIRE ENERGY, INC.
    Inventors: Michael MENDEZ, Craig BEHNKE, Yan POON, Philip LEE
  • Patent number: 8987433
    Abstract: This disclosure provides methods of designing and generating polypeptide variants that have altered properties compared to a parent polypeptide. The present disclosure provides methods of generating polypeptide variants, for example, variant isoprenoid synthases and/or variant prenyl transferases that have at least one desired property not present in the parent polypeptide. The present disclosure further provides polypeptides and polynucleotides encoding variant polypeptides, as well as vectors and host cells comprising the polynucleotides that encode the variant polypeptides. In other embodiments, the present disclosure provides methods of using the variant polypeptides to generate useful products, such as isoprenoid compounds and/or isoprenoid products.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: March 24, 2015
    Assignee: Sapphire Energy, Inc.
    Inventors: Michael Mendez, Craig A. Behnke, Nicole A. Heaps