Patents by Inventor Michael Morytko

Michael Morytko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indazolones as modulators of tnf signaling
    Patent number: 10160748
    Abstract: The disclosure provides indazolone compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the disclosure may be useful for treating immunological and oncological conditions.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: December 25, 2018
    Assignee: AbbVie Inc.
    Inventors: Maria Argiriadi, Eric Breinlinger, Justin D. Dietrich, Michael Friedman, David Ihle, Michael Morytko, Kelly Mullen, Augustine Osuma, Gloria Y. LoSchiavo, Noel S. Wilson
  • INDAZOLONES AS MODULATORS OF TNF SIGNALING
    Publication number: 20180086737
    Abstract: The disclosure provides indazolone compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the disclosure may be useful for treating immunological and oncological conditions.
    Type: Application
    Filed: August 7, 2017
    Publication date: March 29, 2018
    Inventors: Maria Argiriadi, Eric Breinlinger, Justin D. Dietrich, Michael Friedman, David Ihle, Michael Morytko, Kelly Mullen, Augustine Osuma, Gloria Y. LoSchiavo, Noel S. Wilson
  • INDAZOLONES AS MODULATORS OF TNF SIGNALING
    Publication number: 20160304496
    Abstract: The disclosure provides indazolone compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the disclosure may be useful for treating immunological and oncological conditions.
    Type: Application
    Filed: April 15, 2016
    Publication date: October 20, 2016
    Inventors: Maria Argiriadi, Eric Breinlinger, Justin D. Dietrich, Michael Friedman, David Ihle, Michael Morytko, Kelly Mullen, Augustine Osuma, Glora Y. Lo Schiavo, Noel S. Wilson
  • Novel Lipopeptides as Antibacterial Agents
    Publication number: 20090011977
    Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
    Type: Application
    Filed: June 27, 2008
    Publication date: January 8, 2009
    Inventors: Jason Hill, Ian Parr, Michael Morytko, Jim Siedlecki, Xiang Yang Yu, Jared Silverman, Dennis Keith, John Finn, Dale Christensen, Tsvetelina Lazarova, Alan D. Watson, Yan Zhang
  • Novel Lipopeptides as Antibacterial Agents
    Publication number: 20080287347
    Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
    Type: Application
    Filed: June 27, 2008
    Publication date: November 20, 2008
    Inventors: Jason Hill, Ian Parr, Michael Morytko, Jim Siedlecki, Xiang Yang Yu, Jared Silverman, Dennis Keith, John Finn, Dale Christensen, Tsvetelina Lazarova, Alan D. Watson, Yan Zhang
  • Lipopeptides as antibacterial agents
    Patent number: 7408025
    Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: August 5, 2008
    Assignee: Cubist Pharmaceuticals, Inc.
    Inventors: Jason Hill, Ian Parr, Michael Morytko, Jim Siedlecki, Xiang Yang Yu, Jared Silverman, Dennis Keith, John Finn, Dale Christensen, Tsvetelina Lazarova, Alan D. Watson, Yan Zhang
  • Novel Depsipeptides and Process for Preparing Same
    Publication number: 20080119395
    Abstract: The present invention relates to novel depsipeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel depsipeptide compounds and intermediates used in producing these compounds.
    Type: Application
    Filed: January 30, 2008
    Publication date: May 22, 2008
    Inventors: John Finn, Michael Morytko, Ian Parr, Michael Jung
  • Piperazines as P2X7 antagonists
    Publication number: 20080076924
    Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, enantiomers thereof or prodrugs thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.
    Type: Application
    Filed: June 29, 2007
    Publication date: March 27, 2008
    Inventors: Patrick Betschmann, William Carroll, Anna Ericsson, Shannon Fix-Stenzel, Michael Friedman, Gavin Hirst, Nathan Josephsohn, Biqin Li, Arturo Perez-Medrano, Michael Morytko, Paul Rafferty, Haipeng Chen
  • Lipopeptides as antibacterial agents
    Patent number: 7335725
    Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: February 26, 2008
    Assignee: Cubist Pharmaceuticals, Inc.
    Inventors: Jason Hill, Ian Parr, Michael Morytko, Jim Siedlecki, Xian Yang Yu, Jared Silverman, Dennis Keith, John Finn, Dale Christensen, Tsvetelina Lazarova, Alan D. Watson, Yan Zhang
  • Lipopeptide stereoisomers, methods for preparing same and useful intermediates
    Patent number: 7335726
    Abstract: The present invention provides daptomycin stereoisomeric compounds, methods and intermediates for preparing daptomycin and daptomycin stereoisomoeric compounds, as well as pharmaceutical compositions of these compounds and methods of using these compositions as antibacterial agents.
    Type: Grant
    Filed: June 6, 2006
    Date of Patent: February 26, 2008
    Assignee: Cubist Pharmaceuticals, Inc.
    Inventors: Michael Morytko, Yanzhi Zhang, Michael Jung, John Finn
  • Lipopeptide stereoisomers, methods for preparing same, and useful intermediates
    Patent number: 7262268
    Abstract: The present invention provides daptomycin stereoisomeric compounds, methods and intermediates for preparing daptomycin and daptomycin stereoisomoeric compounds, as well as pharmaceutical compositions of these compounds and methods of using these compositions as antibacterial agents.
    Type: Grant
    Filed: August 6, 2002
    Date of Patent: August 28, 2007
    Assignee: Cubist Pharmaceuticals, Inc.
    Inventors: Michael Morytko, Yanzhi Zhang, Michael Jung, John Finn
  • Novel imidazo based heterocycles
    Publication number: 20070099925
    Abstract: The present invention is directed to novel imidazopyrazine and imidazopyrimidine compounds of formula (I) wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
    Type: Application
    Filed: September 1, 2006
    Publication date: May 3, 2007
    Inventors: David Calderwood, Kristine Frank, Patrick Betschmann, Gavin Hirst, Eric Brieinlinger, Michael Morytko, Richard Dixon
  • Lipopeptide stereoisomers, methods for preparing same and useful intermediates
    Publication number: 20060223983
    Abstract: The present invention provides daptomycin stereoisomeric compounds, methods and intermediates for preparing daptomycin and daptomycin stereoisomoeric compounds, as well as pharmaceutical compositions of these compounds and methods of using these compositions as antibacterial agents.
    Type: Application
    Filed: June 6, 2006
    Publication date: October 5, 2006
    Inventors: Michael Morytko, Yanzhi Zhang, Michael Jung, John Finn
  • Novel depsipeptides and process for preparing same
    Publication number: 20060194714
    Abstract: The present invention relates to novel depsipeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel depsipeptide compounds and intermediates used in producing these compounds.
    Type: Application
    Filed: April 28, 2006
    Publication date: August 31, 2006
    Inventors: John Finn, Michael Morytko, Ian Parr, Michael Jung
  • Novel lipopeptides as antibacterial agents
    Publication number: 20050203006
    Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
    Type: Application
    Filed: May 4, 2005
    Publication date: September 15, 2005
    Inventors: Jason Hill, Ian Parr, Michael Morytko, Jim Siedlecki, Xian Yu, Jared Silverman, Dennis Keith, John Finn, Dale Christensen, Tsvetelina Lazarova, Alan Watson, Yan Zhang
  • Lipopeptides as antibacterial agents
    Patent number: 6911525
    Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: June 28, 2005
    Assignee: Cubist Pharmaceuticals, Inc.
    Inventors: Jason Hill, Ian Parr, Michael Morytko, Jim Siedlecki, Xian Yang Yu, Jared Silverman, Dennis Keith, John Finn, Dale Christensen, Tsvetelina Lazarova, Alan D. Watson, Yan Zhang
  • Lipopeptides as antibacterial agents
    Patent number: 6794490
    Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: September 21, 2004
    Assignee: Cubist Pharmaceuticals, Inc.
    Inventors: Jason Hill, Ian Parr, Michael Morytko, Jim Siedlecki, Xian Yang Yu, Jared Silverman, Dennis Keith, John Finn, Dale Christensen, Tsvetelina Lazarova, Alan D. Watson, Yan Zhang
  • Novel lipopeptides as antibacterial agents
    Publication number: 20040067878
    Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
    Type: Application
    Filed: December 15, 2000
    Publication date: April 8, 2004
    Inventors: Jason Hill, Ian Parr, Michael Morytko, Jim Siedlecki, Xiang Yang Yu, Jared Silverman, Dennis Keith, John Finn, Dale Christensen, Tsvetelina Lazarova, Alan D. Watson, Yan Zhang
  • Prolines as antimicrobial agents
    Patent number: 6579894
    Abstract: Transfer ribonucleic acid (tRNA) synthetase inhibitors, salts, and pharmaceutically acceptable compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; L is —C(O)N(Q)CH2—, or —CR10R11OCR12R13—; Q is hydrido, —(CH2)mCO2H and —(CH2)mCO2CH3, m is 1, 2, 3, and 4; R1, R2, R9, R10, R11, R12 and R13 are hydrido or lower alkyl; wherein Het is a heterocyclic moiety, the inhibitors are suitable for use as antimicrobial agents.
    Type: Grant
    Filed: June 17, 2002
    Date of Patent: June 17, 2003
    Assignees: Merck & Co., Inc., Cubist Pharmaceuticals, Inc.
    Inventors: Milton L. Hammond, Aaron H. Leeman, Milana Maletic, Gina M. Santorelli, Sherman T. Waddell, John Finn, Michael Morytko, Siya Ram, Dennis Keith
  • Lipopeptide stereoisomers, methods for preparing same, and useful intermediates
    Publication number: 20030096948
    Abstract: The present invention provides daptomycin stereoisomeric compounds, methods and intermediates for preparing daptomycin and daptomycin stereoisomoeric compounds, as well as pharmaceutical compositions of these compounds and methods of using these compositions as antibacterial agents.
    Type: Application
    Filed: August 6, 2002
    Publication date: May 22, 2003
    Inventors: Michael Morytko, Yanzhi Zhang, Michael Jung, John Finn, Mario Bouchard