Patents by Inventor Michael Munchhof

Michael Munchhof has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • QUINOLINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER
    Publication number: 20220144812
    Abstract: The present disclosure provides novel compounds, compositions comprising the compounds and methods of use thereof.
    Type: Application
    Filed: March 27, 2020
    Publication date: May 12, 2022
    Applicant: Epizyme, Inc.
    Inventors: Eamon Comer, Kenneth W. Duncan, Alexis Cocozaki, John Campbell, Darren Harvey, Michael Munchhof
  • PRMT5 INHIBITORS AND USES THEREOF
    Publication number: 20170224685
    Abstract: Described herein are methods of treating cancer using one or more PRMT5 inhibitors, for example using one or more compounds of Formulae (1-5) or (A-F), pharmaceutically acceptable salts thereof, and/or pharmaceutical compositions thereof. Described herein are methods of treating cancer using one or more PRMT5 inhibitors, for example using one or more compounds of Formulae (1-5) or (A-F), pharmaceutically acceptable salts thereof, and/or pharmaceutical compositions thereof.
    Type: Application
    Filed: August 4, 2015
    Publication date: August 10, 2017
    Applicants: Epizyme, Inc., Glaxosmithkline Intellectual Property Development Limited
    Inventors: Kenneth W. Duncan, Richard Chesworth, Paula Ann Boriack-Sjodin, Michael Munchhof, Lei Jin, Elayne Penebre, Olena I. Barbash
  • PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS
    Publication number: 20070292430
    Abstract: A compound of the formula wherein R1, R2 and R3 are as defined above, which are inhibitors of the enzyme protein kinases such as Janus Kinase 3 and as such are useful therapy as immunosuppressive agents for organ transplants, xeno transplation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases.
    Type: Application
    Filed: July 27, 2007
    Publication date: December 20, 2007
    Inventors: Todd Blumenkopf, Mark Flanagan, Michael Munchhof
  • Pyrrolo[2,3-d]pyrimidine compounds
    Publication number: 20070161666
    Abstract: A compound of the formula wherein R1, R2 and R3 are as defined above, useful as inhibitors of protein kinases, such as the enzyme Janus Kinase 3.
    Type: Application
    Filed: February 22, 2007
    Publication date: July 12, 2007
    Inventors: Todd Blumenkopf, Mark Flanagan, Michael Munchhof
  • NOVEL PYRAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS
    Publication number: 20070117850
    Abstract: Novel pyrazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)- signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer, and fibrotic diseases.
    Type: Application
    Filed: November 8, 2006
    Publication date: May 24, 2007
    Applicant: PFIZER INC.
    Inventors: Michael Munchhof, Laura Blumberg
  • NOVEL IMIDAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS
    Publication number: 20070088037
    Abstract: Novel imidazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)- signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.
    Type: Application
    Filed: November 10, 2006
    Publication date: April 19, 2007
    Applicant: PFIZER INC.
    Inventors: Michael Munchhof, Laura Blumberg
  • Pyrrolo[2,3-d]pyrimidine compounds
    Publication number: 20060241131
    Abstract: A compound of the formula wherein R1, R2 and R3 are as defined above, which are inhibitors of the enzyme protein kinases such as Janus Kinase 3 and as such are useful therapy as immunosuppressive agents for organ transplants, xeno transplation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases.
    Type: Application
    Filed: June 23, 2006
    Publication date: October 26, 2006
    Inventors: Todd Blumenkopf, Mark Flanagan, Michael Munchhof
  • Novel triazole compounds as transforming growth factor (TGF) inhibitors
    Publication number: 20060128761
    Abstract: Novel triazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)-? signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.
    Type: Application
    Filed: February 7, 2006
    Publication date: June 15, 2006
    Inventors: Michael Munchhof, Laura Blumberg
  • Novel pyrazole compounds as transforming growth factor (TGF) inhibitors
    Publication number: 20060025451
    Abstract: Novel pyrazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent; inhibitors of transforming growth factor (“TGF”)-? signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer, and fibrotic diseases.
    Type: Application
    Filed: September 23, 2005
    Publication date: February 2, 2006
    Inventors: Michael Munchhof, Laura Blumberg
  • Pyrrolo[2,3-D]pyrimidine compounds
    Publication number: 20050288313
    Abstract: A compound of the formula wherein R1, R2 and R3 are as defined above, which are inhibitors of the enzyme protein kinases such as Janus Kinase 3 and as such are useful therapy as immunosuppressive agents for organ transplants, xeno transplation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases.
    Type: Application
    Filed: August 24, 2005
    Publication date: December 29, 2005
    Inventors: Todd Blumenkopf, Mark Flanagan, Michael Munchhof
  • Pyrrolo[2,3-D]pyrimidine compounds
    Publication number: 20050197349
    Abstract: A compound of the formula wherein R1, R2 and R3 are as defined above, useful as inhibitors of protein kinases, such as the enzyme Janus Kinase 3.
    Type: Application
    Filed: April 21, 2005
    Publication date: September 8, 2005
    Inventors: Todd Blumenkopf, Mark Flanagan, Michael Munchhof