Abstract: The present disclosure features methods, cells or cell lines, and compositions for increasing the amount of products, e.g., proteins, produced by a cell or cell line by reducing the level of a non-essential endogenous protein.

Abstract: A leaf screen for an air intake of an HVAC system of a vehicle having a hood covering an engine compartment. The leaf screen includes a leaf screen body defining an air inlet opening covered by an integrally molded screen. A seal is integrally molded on a top surface of the leaf screen body in front of the air inlet opening. Bump-stops are integrally molded on the top surface that are engaged by an inner panel of the hood when closed. A method of making the leaf screen includes injecting a polymeric material into a mold to form a body portion. At least one elastomeric material is injected into the mold on one side of the body portion to form a seal and a plurality of bump-stops.

Abstract: Disclosed are genetic control circuits, cells, and methods that use a repressor polypeptide to reduce the transcription rate of an exogenous therapeutic polypeptide encoding gene in response to a change in condition.

Abstract: A leaf screen for an air intake of an HVAC system of a vehicle having a hood covering an engine compartment. The leaf screen includes a leaf screen body defining an air inlet opening covered by an integrally molded screen. A seal is integrally molded on a top surface of the leaf screen body in front of the air inlet opening. Bump-stops are integrally molded on the top surface that are engaged by an inner panel of the hood when closed. A method of making the leaf screen includes injecting a polymeric material into a mold to form a body portion. At least one elastomeric material is injected into the mold on one side of the body portion to form a seal and a plurality of bump-stops.

Abstract: The invention provides compositions and methods for treating a disease or disorder associate with vascular endothelial growth factor (VEGF). Specifically, the invention relates to an oligomerized VEGF binding domain to provide VEGF antagonism, and thereby treat diseases associated thereof.

Abstract: A vehicle cover, such as a tailgate adapted for being raised and lowered relative to the vehicle or a vehicle bumper, includes an adjustable support for supporting an object, such as a gun or fishing pole. In one embodiment, the tailgate includes a recess adapted for receiving the support in an inactive condition. The support has an active condition projecting from the recess for engaging and supporting the object. The support is actuated in various manners.

Abstract: A vehicle cover, such as a tailgate adapted for being raised and lowered relative to the vehicle or a vehicle bumper, includes an adjustable support for supporting an object, such as a gun or fishing pole. In one embodiment, the tailgate includes a recess adapted for receiving the support in an inactive condition. The support has an active condition projecting from the recess for engaging and supporting the object. Various manners of actuating the support are disclosed.

Abstract: The invention provides compositions and methods for treating a disease or disorder associate with vascular endothelial growth factor (VEGF). Specifically, the invention relates to an oligomerized VEGF binding domain to provide VEGF antagonism, and thereby treat diseases associated thereof.

Abstract: The invention provides compositions and methods for treating a disease or disorder associated with vascular endothelial growth factor (VEGF). Specifically, the invention relates to an oligomerized VEGF binding domain to provide VEGF antagonism, and thereby treat diseases associated thereof.

Abstract: The present disclosure provides methods for increasing muscle contractility in a myotubular myopathy subject following administration of fewer than 20 doses of a chimeric polypeptide that has a myotubularin protein and an internalizing moiety.

Abstract: A liquid crystal panel and method are disclosed for increasing optical efficiency in the panel by using a reflector with a high fill factor and arranging an array of transparent pixel electrodes between the reflector and a layer of liquid crystal.

Abstract: The invention provides compositions and methods for treating a disease or disorder associated with vascular endothelial growth factor (VEGF). Specifically, the invention relates to an oligomerized VEGF binding domain to provide VEGF antagonism, and thereby treat diseases associated thereof.

Abstract: A holographic data storage system that includes a write head that includes a pixellated spatial light modulator and a separate or integral phase mask that varies the phase depending on the location in the phase mask that light passes through. The phase variation can be changed over time in a random, pseudo-random, or predetermined fashion. The spatial light modulator and phase mask can be implemented in a liquid crystal SLM (nematic, ferroelectric, or other), in a DMD SLM, in a magneto-optical SLM, or in any other suitable manner.

Abstract: A spatial light modulator (SLM) having a phase mask that is provided as an internal component thereof. The phase mask can be provided as a multilevel surface of relatively higher index of refraction material on an inner surface of a transmissive cover window or as a separate transmissive window between the cover window and the pixels of the SLM. If the phase mask is to be used with a liquid crystal SLM, then it may be desirable to planarize the surface of the cover window contacting the liquid crystal by providing a layer of relatively lower index of refraction material adjacent the multilevel surface. The phase mask can also be provided on the transmissive cover window by patterned ion deposition, exposing patterned light to a photopolymeric material, or in some other suitable fashion. Arranging for the pixel electrodes to be at one of multiple levels rather than lying in an exactly planar relationship can also effectively create the phase mask.

Abstract: Apparatus for electrical stunning and killing poultry comprises a conveyor (31) and means for applying electrical voltage across the heads of the birds (3; 37; 42). In one embodiment, means are also provided for applying a voltage between the bird's head and rear by means of a further electrode (4). In this case, a two stage stun and kill process is used, with the bird being stunned by a voltage applied to it across its head and then killed by a voltage applied between its head and rear, causing fibrillation of the heart. The apparatus may also include means (5; 34) for restraining the bird's heads and/or facilitating contact of the bird's heads with the electrodes. The electrodes themselves may take a number of forms, including dry resilient foam covered by a conductive wire mesh, or a number of parallel sprung pins, or a rail along which the bird's heads slide, or a conductive endless belt. A pair of manual stunning tongs (61) is also described.

Abstract: Apparatus for electrical stunning and killing poultry comprises a conveyor (31) and means for applying electrical voltage across the heads of the birds (3; 37; 42). In one embodiment, means are also provided for applying a voltage between the bird's head and rear by means of a further electrode (4). In this case, a two stage stun and kill process is used, with the bird being stunned by a voltage applied to it across its head and then killed by a voltage applied between its head and rear, causing fibrillation of the heart. The apparatus may also include means (5; 34) for restraining the bird's heads and/or facilitating contact of the bird's heads with the electrodes. The electrodes themselves may take a number of forms, including dry resilient foam covered by a conductive wire mesh, or a number of parallel sprung pins, or a rail along which the bird's heads slide, or a conductive endless belt. A pair of manual stunning tongs (61) is also described.