Abstract: The invention relates to the in vivo transduction of hematopoietic stem and progenitor cells (HSPCs) in a subject, such as a human subject, and to the treatment of subjects suffering from various pathologies, such as blood diseases, metabolic disorders, cancers, and autoimmune diseases, among others.

Abstract: Described herein are compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a subject, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use. In accordance with the composition and methods described herein, mobilized hematopoietic stem and progenitor cells can be withdrawn from a donor and administered to a patient for the treatment of various disorders, including hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others.

Abstract: The invention provides compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a donor, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use. In accordance with the compositions and methods described herein, mobilized hematopoietic stem and progenitor cells can be withdrawn from a donor and administered to a patient for the treatment of various stem cell disorders, including hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others.

Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.

Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.

Abstract: The invention provides compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a donor, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use. In accordance with the compositions and methods described herein, mobilized hematopoietic stem and progenitor cells can be withdrawn from a donor and administered to a patient for the treatment of various stem cell disorders, including hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others. In certain embodiments, the compositions and methods described herein lead to the mobilization of a population of CD34dim cells that have immunosuppressive effects and that can reduce the incidence of graft vs. host disease.

Abstract: The invention provides compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a donor, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use. In accordance with the compositions and methods described herein, mobilized hematopoietic stem and progenitor cells can be withdrawn from a donor and administered to a patient for the treatment of various stem cell disorders, including hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others. In certain embodiments, the compositions and methods described herein lead to the mobilization of a population of CD34dim cells that have immunosuppressive effects and that can reduce the incidence of graft vs. host disease.

Abstract: The invention provides compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a donor, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use. In accordance with the compositions and methods described herein, mobilized hematopoietic stem and progenitor cells can be withdrawn from a donor and administered to a patient for the treatment of various stem cell disorders, including hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others. In certain embodiments, the compositions and methods described herein lead to the mobilization of a population of CD34dim cells that have immunosuppressive effects and that can reduce the incidence of graft vs. host disease.

Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.

Abstract: The invention provides compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a donor, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use. In accordance with the compositions and methods described herein, mobilized hematopoietic stem and progenitor cells can be withdrawn from a donor and administered to a patient for the treatment of various stem cell disorders, including hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others. In certain embodiments, the compositions and methods described herein lead to the mobilization of a population of CD34dim cells that have immunosuppressive effects and that can reduce the incidence of graft vs. host disease.

Abstract: Described herein are compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a subject, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use. In accordance with the composition and methods described herein, mobilized hematopoietic stem and progenitor cells can be withdrawn from a donor and administered to a patient for the treatment of various disorders, including hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others.

Abstract: Described herein are compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a subject, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use. In accordance with the composition and methods described herein, mobilized hematopoietic stem and progenitor cells can be withdrawn from a donor and administered to a patient for the treatment of various disorders, including hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others.

Abstract: The invention provides a method and apparatus for scanning a read/write head of a hard disk drive during manufacture. The method comprises: providing a magnetic sensor; moving the magnetic sensor relative to and in close proximity to the read/write head under test; obtaining measurements from the head under test or the sensor, representing a two-dimensional magnetic map; processing the map to obtain an accurate map of the head sensitivity of the head under test from which the key performance characteristics of the head can be obtained.

Abstract: A pump is provided for pumping a liquid. The pump includes an inlet, an outlet, and a pumping chamber for receiving the liquid from the inlet. An actuator arrangement is also included and is operable between a first position and a second position to pump the liquid from the pumping chamber into the outlet and includes a solenoid actuator having a solenoid coil, a pole element, and a coil former to carry the solenoid coil. The inlet and the pumping chamber are in fluid communication with a supply passage when the actuator arrangement is in the first position. The supply passage extends into or around the solenoid coil and is defined between the coil former and the pole element to allow transfer of heat from the actuator arrangement.

Abstract: The invention provides a method and apparatus for scanning a read/write head of a hard disk drive during manufacture. The method comprises: providing a magnetic sensor; moving the magnetic sensor relative to and in close proximity to the read/write head under test; obtaining measurements from the head under test or the sensor, representing a two-dimensional magnetic map; processing the map to obtain an accurate map of the head sensitivity of the head under test from which the key performance characteristics of the head can be obtained.

Abstract: A method and apparatus for scanning a read/write head of a hard disk drive during manufacture are presented. The method includes: providing a magnetic sensor; moving the magnetic sensor relative to and in close proximity to the read/write head under test; obtaining measurements from the head under test or the sensor, representing a two-dimensional magnetic map; processing the map to obtain an accurate map of the head sensitivity of the head under test from which the key performance characteristics of the head can be obtained.

Abstract: A casing for encapsulation of an electrical component, for example a piezoelectric actuator, comprising an outer layer of a semipermeable material and an inner layer comprising a chemically active, hydrophilic substance that chemically combines with water to form a compound.

Abstract: A dosing device is provided that is suitable for administering a reagent into an exhaust chamber of an internal combustion engine. The device comprises a nozzle body and an insulating jacket wherein the jacket is mounted to the nozzle body at one or more mounting points, and wherein the dosing device is adapted to engage with a port located in the wall of an exhaust chamber. The insulating jacket defines a compartment, which can comprise an insulating material or can be substantially evacuated. The dosing device of the invention is advantageously insulated from the elevated temperatures in the surrounding environment, thereby allowing for the reagent to be maintained at an optimal working temperature range.

Abstract: A fuel injector for use in an internal combustion engine, the fuel injector comprising: a valve needle which is engageable with a valve needle seat to control fuel injection through an injector outlet; an actuator arrangement arranged to control fuel pressure within a control chamber, a surface associated with the valve needle being exposed to fuel pressure within the control chamber such that fuel pressure variations within the control chamber control movement of the valve needle relative to the valve needle seat; damping means for damping opening movement of the valve member, the damping means comprising a damper chamber and the damping means being arranged such that fuel pressure variations within the damper chamber damp opening movement of the valve member wherein the damping means is arranged such that in use there is a through flow of fuel through the damper chamber.

Abstract: The invention relates to a fuel injection valve for internal combustion engines, comprising a valve body (1), with a drilling (3) embodied therein and defined at the combustion chamber end thereof by a conical valve seat (18) from which at least one injection opening (20) leads. A hollow valve needle (8) is arranged in the drilling (3) such as to be displaced longitudinally, comprising a valve sealing surface (35) at the end thereof facing the valve seat (18). A first sealing region (31; 34) and a second sealing region (32; 46; 48) are embodied on the valve sealing surface (35), whereby, on contact of the hollow valve needle (8) on the valve seat (18), the first sealing region (31; 34) provides a seal upstream of the at least one injection opening (20) and the second sealing region (32; 46; 48) downstream thereof.