Patents by Inventor Michael P. Gustafson
Michael P. Gustafson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240159761Abstract: Methods and materials for identifying mammals having cancer as being likely to respond to treatment with a checkpoint inhibitor are provided herein. For example, materials and methods for using immune profiling with particular biomarkers on circulating patient immune cells to predict patient response to checkpoint inhibitors (e.g., pembrolizumab) are provided herein.Type: ApplicationFiled: March 9, 2022Publication date: May 16, 2024Inventors: Svetlana Bornschlegl, Allan B. Dietz, Michael P. Gustafson
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Publication number: 20210405049Abstract: This document provides methods and materials involved in assessing immune system profiles. For example, methods and materials for performing flow cytometry to determine the number of CD4+ lymphocytes, CD8+ lymphocytes, regulatory T cells, B cells, NK cells, granulocytes, CD14+HLA-DRlo/neg monocytes, and/or CD86+ monocytes per unit volume (e.g., cells per ?L or mL) of whole blood (e.g., fresh, un-manipulated whole blood) obtained from a mammal (e.g., a human) are provided.Type: ApplicationFiled: September 10, 2021Publication date: December 30, 2021Applicant: Mayo Foundation for Medical Education and ResearchInventors: Allan B. Dietz, Michael P. Gustafson
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Patent number: 11143653Abstract: This document provides methods and materials involved in assessing immune system profiles. For example, methods and materials for performing flow cytometry to determine the number of CD4+ lymphocytes, CD8+ lymphocytes, regulatory T cells, B cells, NK cells, granulocytes, CD14+HLA-DRlo/neg g monocytes, and/or CD86+ monocytes per unit volume (e.g., cells per ?L or mL) of whole blood (e.g., fresh, un-manipulated whole blood) obtained from a mammal (e.g., a human) are provided.Type: GrantFiled: April 13, 2018Date of Patent: October 12, 2021Assignee: Mayo Foundation for Medical Education and ResearchInventors: Allan B. Dietz, Michael P. Gustafson
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Publication number: 20210154234Abstract: This document provides methods and materials relating to platelet lysates. For example, methods and materials for using platelet lysate compositions to grow adult stem cells, to differentiate adult stem cells, to grow primary cell cultures, to grow tumor stem cells, and to identify effective growth factors are provided.Type: ApplicationFiled: January 12, 2021Publication date: May 27, 2021Inventors: Allan B. Dietz, Michael P. Gustafson, Greg W. Butler
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Patent number: 10925901Abstract: This document provides methods and materials relating to platelet lysates. For example, methods and materials for using platelet lysate compositions to grow adult stem cells, to differentiate adult stem cells, to grow primary cell cultures, to grow tumor stem cells, and to identify effective growth factors are provided.Type: GrantFiled: December 28, 2018Date of Patent: February 23, 2021Assignee: Mayo Foundation for Medical Education and ResearchInventors: Allan B. Dietz, Michael P. Gustafson, Greg W. Butler
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Publication number: 20190209617Abstract: This document provides methods and materials relating to platelet lysates. For example, methods and materials for using platelet lysate compositions to grow adult stem cells, to differentiate adult stem cells, to grow primary cell cultures, to grow tumor stem cells, and to identify effective growth factors are provided.Type: ApplicationFiled: December 28, 2018Publication date: July 11, 2019Inventors: Allan B. Dietz, Michael P. Gustafson, Greg W. Butler
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Publication number: 20190086415Abstract: This document provides methods and materials for treating patients following an assessment of immune subtypes such as an assessment of peripheral blood phenotypes. For example, methods and materials for treating a mammal having a medical condition after assessing a mammal's level of CD14+/DR? cells (e.g., CD14+/DR? monocytes) and level of CD4+ cells (e.g., CD4+ T cells) and classifying the mammal has being likely to experience a favorable or unfavorable medical outcome based at least in part on the mammal's level of CD14+/DR? cells and level of CD4+ cells are provided.Type: ApplicationFiled: September 21, 2018Publication date: March 21, 2019Applicant: Mayo Foundation for Medical Education and ResearchInventors: Allan B. Dietz, Michael P. Gustafson, Yi Lin
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Patent number: 10166258Abstract: This document provides methods and materials relating to platelet lysates. For example, methods and materials for using platelet lysate compositions to grow adult stem cells, to differentiate adult stem cells, to grow primary cell cultures, to grow tumor stem cells, and to identify effective growth factors are provided.Type: GrantFiled: December 3, 2015Date of Patent: January 1, 2019Assignee: Mayo Foundation for Medical Education and ResearchInventors: Allan B. Dietz, Michael P. Gustafson, Greg W. Butler
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Patent number: 10094835Abstract: This document provides methods and materials for treating patients following an assessment of immune subtypes such as an assessment of peripheral blood phenotypes. For example, methods and materials for treating a mammal having a medical condition after assessing a mammal's level of CD14+/DR? cells (e.g., CD14+/DR? monocytes) and level of CD4+ cells (e.g., CD4+ T cells) and classifying the mammal has being likely to experience a favorable or unfavorable medical outcome based at least in part on the mammal's level of CD14+/DR? cells and level of CD4+ cells are provided.Type: GrantFiled: May 7, 2014Date of Patent: October 9, 2018Assignee: Mayo Foundation for Medical Education and ResearchInventors: Allan B. Dietz, Michael P. Gustafson, Yi Lin
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Publication number: 20180238879Abstract: This document provides methods and materials involved in assessing immune system profiles. For example, methods and materials for performing flow cytometry to determine the number of CD4+ lymphocytes, CD8+ lymphocytes, regulatory T cells, B cells, NK cells, granulocytes, CD14+HLA-DRlo/neg g monocytes, and/or CD86+ monocytes per unit volume (e.g., cells per ?L or mL) of whole blood (e.g., fresh, un-manipulated whole blood) obtained from a mammal (e.g., a human) are provided.Type: ApplicationFiled: April 13, 2018Publication date: August 23, 2018Applicant: Mayo Foundation for Medical Education and ResearchInventors: Allan B. Dietz, Michael P. Gustafson
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Patent number: 9970936Abstract: This document provides methods and materials involved in assessing immune system profiles. For example, methods and materials for performing flow cytometry to determine the number of CD4+ lymphocytes, CD8+ lymphocytes, regulatory T cells, B cells, NK cells, granulocytes, CD14+HLA-DRlo/neg monocytes, and/or CD86+ monocytes per unit volume (e.g., cells per ?L or mL) of whole blood (e.g., fresh, un-manipulated whole blood) obtained from a mammal (e.g., a human) are provided.Type: GrantFiled: November 12, 2013Date of Patent: May 15, 2018Assignee: Mayo Foundation for Medical Education and ResearchInventors: Michael P. Gustafson, Allan B. Dietz
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Publication number: 20160266115Abstract: This document provides methods and materials involved in assessing immune system profiles. For example, methods and materials for performing flow cytometry to determine the number of CD4+ lymphocytes, CD8+ lymphocytes, regulatory T cells, B cells, NK cells, granulocytes, CD14+HLA-DRlo/neg monocytes, and/or CD86+ monocytes per unit volume (e.g., cells per ?L or mL) of whole blood (e.g., fresh, un-manipulated whole blood) obtained from a mammal (e.g., a human) are provided.Type: ApplicationFiled: November 12, 2013Publication date: September 15, 2016Inventors: Michael P. Gustafson, Allan B. Dietz
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Publication number: 20160082047Abstract: This document provides methods and materials relating to platelet lysates. For example, methods and materials for using platelet lysate compositions to grow adult stem cells, to differentiate adult stem cells, to grow primary cell cultures, to grow tumor stem cells, and to identify effective growth factors are provided.Type: ApplicationFiled: December 3, 2015Publication date: March 24, 2016Inventors: Allan B. Dietz, Michael P. Gustafson, Greg W. Butler
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Publication number: 20160077096Abstract: This document provides methods and materials for treating patients following an assessment of immune subtypes such as an assessment of peripheral blood phenotypes. For example, methods and materials for treating a mammal having a medical condition after assessing a mammal's level of CD14+/DR? cells (e.g., CD14+/DR? monocytes) and level of CD4+ cells (e.g., CD4+ T cells) and classifying the mammal has being likely to experience a favorable or unfavorable medical outcome based at least in part on the mammal's level of CD14+/DR? cells and level of CD4+ cells are provided.Type: ApplicationFiled: May 7, 2014Publication date: March 17, 2016Inventors: Allan B. DIETZ, Michael P. GUSTAFSON, Yi LIN
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Publication number: 20110171731Abstract: This document provides methods and materials relating to platelet lysates. For example, methods and materials for using platelet lysate compositions to grow adult stem cells, to differentiate adult stem cells, to grow primary cell cultures, to grow tumor stem cells, and to identify effective growth factors are provided.Type: ApplicationFiled: September 16, 2009Publication date: July 14, 2011Inventors: Allan B. Dietz, Michael P. Gustafson, Greg W. Butler
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Patent number: 6015700Abstract: A nucleic acid and corresponding polypeptide that aids in the regulation of the cell cycle in Pneumocystis carinii is described. Antibodies generated against a unique carboxyl-terminus region of the polypeptide have specific binding affinity for P. carinii Cdc2 polypeptide and are benificial in diagnosing and monitoring P. carinii infection in patients. Expression of P. carinii Cdc2 polypeptide in cdc2-mutant yeast and other cdc2-mutant organisms provides a for model for studying the life cycle of P. carinii and for identifying novel therapeutics.Type: GrantFiled: June 8, 1998Date of Patent: January 18, 2000Assignee: Mayo Foundation for Medical Education and ResearchInventors: Andrew H. Limper, Edward B. Leof, Charles F. Thomas, Michael P. Gustafson
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Patent number: 5863741Abstract: A nucleic acid and corresponding polypeptide that aids in the regulation of the cell cycle in Pneumocystis carinii is described. Antibodies generated against a unique carboxyl-terminus region of the polypeptide have specific binding affinity for P. carinii Cdc2 polypeptide and are beneficial in diagnosing and monitoring P. carinii infection in patients. Expression of P. carinii Cdc2 polypeptide in cdc2-mutant yeast and other cdc2-mutant organisms provides a useful model for studying the life cycle of P. carinii and for identifying novel therapeutics.Type: GrantFiled: June 13, 1997Date of Patent: January 26, 1999Assignee: Mayo Foundation for Medical Education and ResearchInventors: Andrew H. Limper, Edward B. Leof, Charles F. Thomas, Michael P. Gustafson