Patents by Inventor Michael P. Hall
Michael P. Hall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8352193Abstract: Methods and apparatuses for deriving the sequence of an oligomer. In one exemplary method for deriving the sequence of a polypeptide, a predetermined set of mass/charge values for amino acid sequences is stored. An abundance value from mass spectrum data for each mass/charge value in the predetermined set is determined to produce a plurality of abundance values. A first ranking, based on the plurality of abundance values, is calculated for each sequence of a set of amino acid sequences having a first number of amino acids. A second ranking, based on the plurality of abundance values, for each sequence of a set of amino acid sequences having a second number of amino acids is calculated. A cumulative ranking, based on the first ranking and the second ranking, is calculated for each sequence of a set of amino acid sequences having at least the second number of amino acids.Type: GrantFiled: May 30, 2006Date of Patent: January 8, 2013Assignee: Target Discovery, Inc.Inventors: Luke V. Schneider, Michael P. Hall, Robert Petesch
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Patent number: 7316931Abstract: Mass tagging methods are provided that lead to mass spectrometer detection sensitivities and molecular discriminations that are improved over other methods. In particular the methods are useful for discriminating tagged molecules and fragments of molecules from chemical noise in the mass spectrum. These mass tagging methods are useful for oligomer sequencing, determining the relative abundances of molecules from different samples, and identifying individual molecules or chemical processing steps in combinatorial chemical libraries. The methods provided are useful for the simultaneous analysis of multiple molecules and reaction mixtures by mass spectrometric methods.Type: GrantFiled: August 6, 2004Date of Patent: January 8, 2008Assignee: Target Discovery, Inc.Inventors: Luke V. Schneider, Michael P. Hall, Robert Petesch
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Patent number: 7211376Abstract: The invention provides methods, compositions, apparatus, and a computer data retrieval system for conducting proteomics.Type: GrantFiled: November 21, 2003Date of Patent: May 1, 2007Assignee: Target Discovery, Inc.Inventors: Luke V. Schneider, Michael P. Hall, Robert Petesch, Jeffrey N. Peterson
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Publication number: 20060073485Abstract: Mass tagging methods are provided that lead to mass spectrometer detection sensitivities and molecular discriminations that are improved over other methods. In particular the methods are useful for discriminating tagged molecules and fragments of molecules from chemical noise in the mass spectrum. These mass tagging methods are useful for oligomer sequencing, determining the relative abundances of molecules from different samples, and identifying individual molecules or chemical processing steps in combinatorial chemical libraries. The methods provided are useful for the simultaneous analysis of multiple molecules and reaction mixtures by mass spectrometric methods.Type: ApplicationFiled: August 6, 2004Publication date: April 6, 2006Applicant: Taget Discovery, Inc.Inventors: Luke V. Schneider, Michael P. Hall, Robert Petesch
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Patent number: 6962818Abstract: Mass tagging methods are provided that lead to mass spectrometer detection sensitivities and molecular discriminations that are improved over other methods. In particular the methods are useful for discriminating tagged molecules and fragments of molecules from chemical noise in the mass spectrum. These mass tagging methods are useful for oligomer sequencing, determining the relative abundances of molecules from different samples, and identifying individual molecules or chemical processing steps in combinatorial chemical libraries. The methods provided are useful for the simultaneous analysis of multiple molecules and reaction mixtures by mass spectrometric methods.Type: GrantFiled: October 19, 2001Date of Patent: November 8, 2005Assignee: Target DiscoveryInventors: Luke V. Schneider, Michael P. Hall, Robert Petesch
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Publication number: 20040262160Abstract: The present method provides methods and apparatus for separating proteins using a series of electrophoretic methods that utilize controlled fractionation and labeling techniques to resolve mixtures of proteins. The samples for each electrophoretic method other than the initial method, contain only a subset of proteins resolved in the preceding method. The methods can be used in a variety of different applications including, creating proteomic databases, comparative expression studies, diagnostics, structure activity relationships and metabolic engineering investigations.Type: ApplicationFiled: July 26, 2004Publication date: December 30, 2004Applicant: Target Discovery, Inc.Inventors: Luke V. Schneider, Michael P. Hall, Robert Petesch
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Patent number: 6818112Abstract: The present method provides methods and apparatus for separating proteins using a series of electrophoretic methods that utilize controlled fractionation and labeling techniques to resolve mixtures of proteins. The samples for each electrophoretic method other than the initial method, contain only a subset of proteins resolved in the preceding method. The methods can be used in a variety of different applications including, creating proteomic databases, comparative expression studies, diagnostics, structure activity relationships and metabolic engineering investigations.Type: GrantFiled: January 13, 2003Date of Patent: November 16, 2004Assignee: Target Discovery, Inc.Inventors: Luke V. Schneider, Michael P. Hall, Robert Petesch
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Publication number: 20040209251Abstract: Methods and apparatuses for deriving the sequence of an oligomer. In one exemplary method for deriving the sequence of a polypeptide, a predetermined set of mass/charge values for amino acid sequences is stored. An abundance value from mass spectrum data for each mass/charge value in the predetermined set is determined to produce a plurality of abundance values. A first ranking, based on the plurality of abundance values, is calculated for each sequence of a set of amino acid sequences having a first number of amino acids. A second ranking, based on the plurality of abundance values, for each sequence of a set of amino acid sequences having a second number of amino acids is calculated. A cumulative ranking, based on the first ranking and the second ranking, is calculated for each sequence of a set of amino acid sequences having at least the second number of amino acids.Type: ApplicationFiled: October 19, 2001Publication date: October 21, 2004Inventors: Luke V. Schneider, Michael P. Hall, Robert Petesch
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Patent number: 6716636Abstract: The present invention provides a method for protein sequencing using mass spectrometry. Also provided are protein labeling agents and labeled proteins for use in conjunction with the present method.Type: GrantFiled: October 19, 2000Date of Patent: April 6, 2004Assignee: Target Discovery, Inc.Inventors: Luke V. Schneider, Michael P. Hall, Jeffrey N. Peterson
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Patent number: 6706529Abstract: The present invention provides a method for protein sequencing using mass spectrometry. Also provided are protein labeling agents and labeled proteins for use in conjunction with the present method.Type: GrantFiled: February 6, 2002Date of Patent: March 16, 2004Assignee: Target Discovery, Inc.Inventors: Luke V. Schneider, Michael P. Hall, Jeffrey N. Peterson
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Patent number: 6677114Abstract: The invention provides methods, compositions, apparatus, and a computer data retrieval system for conducting proteomics.Type: GrantFiled: February 25, 2000Date of Patent: January 13, 2004Assignee: Target Discovery, Inc.Inventors: Luke V. Schneider, Michael P. Hall, Robert Petesch, Jeffrey N. Peterson
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Publication number: 20030119069Abstract: Provided are methods of labeling multiple proteins in protein mixtures to prepare the samples for identification and analysis, and useful in developing a proteomics database.Type: ApplicationFiled: November 15, 2002Publication date: June 26, 2003Applicant: Target Discovery, Inc.Inventors: Luke V. Schneider, Michael P. Hall, Robert M. Petesch, Jeffrey N. Peterson
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Publication number: 20030106797Abstract: The present method provides methods and apparatus for separating proteins using a series of electrophoretic methods that utilize controlled fractionation and labeling techniques to resolve mixtures of proteins. The samples for each electrophoretic method other than the initial method, contain only a subset of proteins resolved in the preceding method. The methods can be used in a variety of different applications including, creating proteomic databases, comparative expression studies, diagnostics, structure activity relationships and metabolic engineering investigations.Type: ApplicationFiled: January 13, 2003Publication date: June 12, 2003Applicant: Target Discovery, Inc.Inventors: Luke V. Schneider, Michael P. Hall, Robert Petesch
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Patent number: 6537432Abstract: The present method provides methods and apparatus for separating proteins using a series of electrophoretic methods that utilize controlled fractionation and labeling techniques to resolve mixtures of proteins. The samples for each electrophoretic method other than the initial method, contain only a subset of proteins resolved in the preceding method. The methods can be used in a variety of different applications including, creating proteomic databases, comparative expression studies, diagnostics, structure activity relationships and metabolic engineering investigations.Type: GrantFiled: February 25, 2000Date of Patent: March 25, 2003Assignee: Target Discovery, Inc.Inventors: Luke V. Schneider, Michael P. Hall, Robert Petesch
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Publication number: 20020172961Abstract: Mass tagging methods are provided that lead to mass spectrometer detection sensitivities and molecular discriminations that are improved over other methods. In particular the methods are useful for discriminating tagged molecules and fragments of molecules from chemical noise in the mass spectrum. These mass tagging methods are useful for oligomer sequencing, determining the relative abundances of molecules from different samples, and identifying individual molecules or chemical processing steps in combinatorial chemical libraries. The methods provided are useful for the simultaneous analysis of multiple molecules and reaction mixtures by mass spectrometric methods.Type: ApplicationFiled: October 19, 2001Publication date: November 21, 2002Applicant: Target DiscoveryInventors: Luke V. Schneider, Michael P. Hall, Robert Petesch
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Publication number: 20020132357Abstract: The present invention provides a method for protein sequencing using mass spectrometry. Also provided are protein labeling agents and labeled proteins for use in conjunction with the present method.Type: ApplicationFiled: February 6, 2002Publication date: September 19, 2002Applicant: Target DiscoveryInventors: Luke V. Schneider, Michael P. Hall, Jeffrey N. Peterson
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Patent number: 6379971Abstract: The present invention provides a method for protein sequencing using mass spectrometry. Also provided are protein labeling agents and labeled proteins for use in conjunction with the present method.Type: GrantFiled: February 25, 2000Date of Patent: April 30, 2002Assignee: Target Discovery, Inc.Inventors: Luke V. Schneider, Michael P. Hall, Jeffrey N. Peterson