Patents by Inventor Michael P. Mittmann
Michael P. Mittmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8697334Abstract: An encoded microparticle having a spatial code is provided; and a set of encoded microparticles possessing subsets each provided with a distinguishable spatial code, wherein the codes comply with a pre-determined coding scheme. Presented are also methods of using the encoded microparticles in various biological assays, such as various multiplex assays and visualizing them by creating a digital image of the encoded microparticles and determining whether false positives are present. Further are provided methods of manufacture of the encoded microparticles which employ ferromagnetic nanoparticles applied using spin-on-glass techniques.Type: GrantFiled: December 23, 2011Date of Patent: April 15, 2014Assignee: Affymetrix, Inc.Inventors: Randall J. True, Martin J. Goldberg, Michael Ru, Michael P. Mittmann
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Publication number: 20120196381Abstract: An encoded microparticle having a spatial code is provided; and a set of encoded microparticles possessing subsets each provided with a distinguishable spatial code, wherein the codes comply with a pre-determined coding scheme. Presented are also methods of using the encoded microparticles in various biological assays, such as various multiplex assays and visualizing them by creating a digital image of the encoded microparticles and determining whether false positives are present. Further are provided methods of manufacture of the encoded microparticles which employ ferromagnetic nanoparticles applied using spin-on-glass techniques.Type: ApplicationFiled: December 23, 2011Publication date: August 2, 2012Applicant: Affymetrix, Inc.Inventors: Randall J. True, Martin J. Goldberg, Michael Ru, Michael P. Mittmann
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Publication number: 20120151746Abstract: Disclosed are apparatuses, systems and methods for attachment of substrates to supports. Disclosed are integrated pick-and-place curing apparatuses and systems and methods for using them. Integration of pick-and-place and curing functionalities provides higher efficiency and effectiveness compared to approaches which separate the two functions. Also disclosed are systems and methods for simultaneous attachment of a plurality of substrates to a support. Substrates include, within certain embodiments, arrays of biological polymers which are unaffected by the disclosed pick-and-place curing approaches.Type: ApplicationFiled: December 16, 2011Publication date: June 21, 2012Applicant: AFFYMETRIX, INC.Inventors: John Mundaden, Chi Sou Yu, Michael P. Mittmann
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Patent number: 6949638Abstract: Systems, methods, and products are described for synthesizing probe arrays of polymers. A mask is used that includes reticle areas, each of which includes a number of reticles associated with a same synthesis area on a substrate. A method includes (a) aligning the mask with respect to the substrate so that a first reticle of a first reticle area is aligned with a first synthesis area and so that a second reticle of the first reticle area is aligned with a first discard area on the substrate; (b) coupling monomers on the first synthesis area at locations determined by the first reticle; (c) re-aligning the mask with respect to the substrate so that the second reticle is aligned with the first synthesis area; and (d) coupling monomers on the first synthesis area at locations determined by the second reticle. The monomers may be, for example, nucleotides, amino acids or saccharides.Type: GrantFiled: April 3, 2001Date of Patent: September 27, 2005Assignee: Affymetrix, Inc.Inventors: Michael P. Mittmann, Earl A. Hubbell
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Patent number: 6826296Abstract: Systems and method for organizing information relating to the design of polymer probe array chips including oligonucleotide array chips. A database model is provided which organizes information interrelating probes on a chip, genomic items investigated by the chip, and sequence information relating to the design of the chip. The model is readily translatable into database languages such as SQL. The database model scales to permit storage of information about large numbers of chips having complex designs.Type: GrantFiled: December 14, 2000Date of Patent: November 30, 2004Assignee: Affymetrix, Inc.Inventors: David J. Balaban, Earl Hubbell, Michael P. Mittmann, Gloria Cheung, Josie Dai
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Publication number: 20040146901Abstract: Methods of selecting tag nucleic acids and VLSIPS™ arrays and the arrays made by the methods are used to label and track compositions, including cells and viruses, e.g., in libraries of cells or viruses. In addition to providing a way of tracking compositions in mixtures, the tags facilitate analysis of cell and viral phenotypes.Type: ApplicationFiled: November 5, 2003Publication date: July 29, 2004Applicant: AFFYMETRIX, INC.Inventors: MacDonald S. Morris, Daniel D. Shoemaker, Ronald W. Davis, Michael P. Mittmann
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Publication number: 20030220748Abstract: Computer-aided techniques for analyzing biological sequences like nucleic acids are provided. The computer system may analyze hybridization intensities indicating hybridization affinity between nucleic acid probes and a sample nucleic acid sequence in order to call bases in the sample sequence. Multiple base calls may be combined to form a single base call. Additionally, the computer system may analyze hybridization intensities in order to monitor gene expression or the change in gene expression as compared to a baseline.Type: ApplicationFiled: May 15, 2003Publication date: November 27, 2003Applicant: AFFYMETRIX, INC., a California corporationInventors: Teresa A. Webster, MacDonald S. Morris, Michael P. Mittmann, David J. Lockhart, Ming-Hsiu Ho, Derek Bernhart, Luis C. Jevons
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Patent number: 6600996Abstract: Computer-aided techniques for analyzing biological sequences like nucleic acids are provided. The computer system may analyze hybridization intensities indicating hybridization affinity between nucleic acid probes and a sample nucleic acid sequence in order to call bases in the sample sequence. Multiple base calls may be combined to form a single base call. Additionally, the computer system may analyze hybridization intensities in order to monitor gene expression or the change in gene expression as compared to a baseline.Type: GrantFiled: March 28, 1997Date of Patent: July 29, 2003Assignee: Affymetrix, Inc.Inventors: Teresa A. Webster, MacDonald S. Morris, Michael P. Mittmann, David J. Lockhart, Ming-Hsiu Ho, Derek Bernhart, Luis C. Jevons
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Publication number: 20030104410Abstract: Nucleic acid sequences are provided that are complementary, in one embodiment, to a wide variety of human genes. The sequences are provided in such a way as to make them available for a variety of analyses. As such, they are related to diverse fields impacted by the nature of molecular interaction, including chemistry, biology, medicine, and medical diagnostics.Type: ApplicationFiled: March 15, 2002Publication date: June 5, 2003Applicant: Affymetrix, Inc.Inventor: Michael P. Mittmann
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Publication number: 20030104436Abstract: Methods of selecting tag nucleic acids and VLSIPS™ arrays and the arrays made by the methods are used to label and track compositions, including cells and viruses, e.g., in libraries of cells or viruses. In addition to providing a way of tracking compositions in mixtures, the tags facilitate analysis of cell and viral phenotypes.Type: ApplicationFiled: August 23, 2002Publication date: June 5, 2003Applicant: AFFYMETRIX, INC.Inventors: MacDonald S. Morris, Daniel D. Shoemaker, Ronald W. Davis, Michael P. Mittmann
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Publication number: 20020183933Abstract: Computer-aided techniques for analyzing biological sequences like nucleic acids are provided. The computer system may analyze hybridization intensities indicating hybridization affinity between nucleic acid probes and a sample nucleic acid sequence in order to call bases in the sample sequence. Multiple base calls may be combined to form a single base call. Additionally, the computer system may analyze hybridization intensities in order to monitor gene expression or the change in gene expression as compared to a baseline.Type: ApplicationFiled: March 28, 1997Publication date: December 5, 2002Inventors: TERESA A. WEBSTER, MACDONALD S. MORRIS, MICHAEL P. MITTMANN, DAVID J. LOCKHART, DEREK BERNHART, LUIS C. JEVONS
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Patent number: 6458530Abstract: Methods of selecting tag nucleic acids and VLSIPS™ arrays and the arrays made by the methods are used to label and track compositions, including cells and viruses, e.g., in libraries of cells or viruses. In addition to providing a way of tracking compositions in mixtures, the tags facilitate analysis of cell and viral phenotypes.Type: GrantFiled: April 4, 1996Date of Patent: October 1, 2002Assignee: Affymetrix Inc.Inventors: Macdonald S. Morris, Daniel D. Shoemaker, Ronald W. Davis, Michael P. Mittmann
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Publication number: 20020102564Abstract: Systems, methods, and products are described for synthesizing probe arrays of polymers. A mask is used that includes reticle areas, each of which includes a number of reticles associated with a same synthesis area on a substrate. A method includes (a) aligning the mask with respect to the substrate so that a first reticle of a first reticle area is aligned with a first synthesis area and so that a second reticle of the first reticle area is aligned with a first discard area on the substrate; (b) coupling monomers on the first synthesis area at locations determined by the first reticle; (c) re-aligning the mask with respect to the substrate so that the second reticle is aligned with the first synthesis area; and (d) coupling monomers on the first synthesis area at locations determined by the second reticle. The monomers may be, for example, nucleotides, amino acids or saccharides.Type: ApplicationFiled: April 3, 2001Publication date: August 1, 2002Inventors: Michael P. Mittmann, Earl A. Hubbell
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Patent number: 6188783Abstract: Systems and method for organizing information relating to the design of polymer probe array chips including oligonucleotide array chips. A database model is provided which organizes information interrelating probes on a chip, genomic items investigated by the chip, and sequence information relating to the design of the chip. The model is readily translatable into database languages such as SQL. The database model scales to permit storage of information about large numbers of chips having complex designs.Type: GrantFiled: July 24, 1998Date of Patent: February 13, 2001Assignee: Affymetrix, Inc.Inventors: David J. Balaban, Earl A. Hubbell, Michael P. Mittmann, Gloria Cheung, Josie Dai