Patents by Inventor Michael P. Murphy
Michael P. Murphy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240065763Abstract: A system and method for preoperative surgical planning includes an electronic device with an interface for a user to input preoperative data, which may include an image (for example, a body part) and/or patient information (for example, medical information) and a server receiving and storing the preoperative data in a data storage. An application includes an implementation of an artificial intelligence model (for example, a neural network), which is executed using the preoperative data as input to generate a preoperative plan for a surgical procedure. The preoperative plan can include a list of medical instruments for use during the surgical procedure and/or a list of surgical steps to perform the surgical procedure Information about the surgical procedure (operative data) is captured during and/or after the surgical procedure. The operative data is stored in the data storage.Type: ApplicationFiled: August 25, 2022Publication date: February 29, 2024Inventor: Michael P. Murphy
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Publication number: 20230273109Abstract: Methods for determining a radius of gyration of a particle in solution using a light scattering detector are provided. The method may include passing the solution through a flowpath in a sample cell, determining respective angular normalization factors for first and second angles of the detector, obtaining a first scattering intensity of the particle in solution at the first angle, obtaining a second scattering intensity of the particle in solution at the second angle, obtaining a 10° scattering intensity of the particle in solution at an angle of about 10°, determining a first particle scattering factor, determining a second particle scattering factor, plotting an angular dissymmetry plot, fitting a line to the angular dissymmetry plot, determining a slope of the line at a selected location on the line, determining the radius of gyration of the particle in solution from the slope of the line, and outputting the radius of gyration.Type: ApplicationFiled: May 1, 2023Publication date: August 31, 2023Inventors: Max HANEY, Michael P. MURPHY
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Patent number: 11674880Abstract: Methods for determining a radius of gyration of a particle in solution using a light scattering detector are provided. The method may include passing the solution through a flowpath in a sample cell, determining respective angular normalization factors for first and second angles of the detector, obtaining a first scattering intensity of the particle in solution at the first angle, obtaining a second scattering intensity of the particle in solution at the second angle, obtaining a 10° scattering intensity of the particle in solution at an angle of about 10°, determining a first particle scattering factor, determining a second particle scattering factor, plotting an angular dissymmetry plot, fitting a line to the angular dissymmetry plot, determining a slope of the line at a selected location on the line, determining the radius of gyration of the particle in solution from the slope of the line, and outputting the radius of gyration.Type: GrantFiled: September 9, 2021Date of Patent: June 13, 2023Assignee: M & J Scientific, LLCInventors: Max Haney, Michael P. Murphy
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Publication number: 20220112152Abstract: Novel salicylamine derivatives are targeted directly to the mitochondria to increase effectiveness and lower required dosages in the treatment of conditions caused by inflammation or oxidative stress.Type: ApplicationFiled: January 27, 2020Publication date: April 14, 2022Inventors: Kevin Moore, Michael P. Murphy, Naji Abumrad, John Fuller, Jr.
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Publication number: 20220107270Abstract: Sample cells, light scattering detectors utilizing the sample cells, and methods for using the same are provided. The sample cell may include a body defining a flowpath extending axially therethrough. The flowpath may include a cylindrical inner section interposed between a first outer section and a second outer section. The first outer section may be frustoconical. A first end portion of the first outer section may be in direct fluid communication with the inner section and may have a cross-sectional area relatively smaller than a cross-sectional area at a second end portion thereof. The body may further define an inlet in direct fluid communication with the inner section. The inlet may be configured to direct a sample to the inner section of the flowpath.Type: ApplicationFiled: December 15, 2021Publication date: April 7, 2022Inventors: Max HANEY, Michael P. MURPHY
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Patent number: 11226287Abstract: Sample cells, light scattering detectors utilizing the sample cells, and methods for using the same are provided. The sample cell may include a body defining a flowpath extending axially therethrough. The flowpath may include a cylindrical inner section interposed between a first outer section and a second outer section. The first outer section may be frustoconical. A first end portion of the first outer section may be in direct fluid communication with the inner section and may have a cross-sectional area relatively smaller than a cross-sectional area at a second end portion thereof. The body may further define an inlet in direct fluid communication with the inner section. The inlet may be configured to direct a sample to the inner section of the flowpath.Type: GrantFiled: January 2, 2019Date of Patent: January 18, 2022Assignee: M & J Scientific, LLCInventors: Max Haney, Michael P. Murphy
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Publication number: 20210404941Abstract: Methods for determining a radius of gyration of a particle in solution using a light scattering detector are provided. The method may include passing the solution through a flowpath in a sample cell, determining respective angular normalization factors for first and second angles of the detector, obtaining a first scattering intensity of the particle in solution at the first angle, obtaining a second scattering intensity of the particle in solution at the second angle, obtaining a 10° scattering intensity of the particle in solution at an angle of about 10°, determining a first particle scattering factor, determining a second particle scattering factor, plotting an angular dissymmetry plot, fitting a line to the angular dissymmetry plot, determining a slope of the line at a selected location on the line, determining the radius of gyration of the particle in solution from the slope of the line, and outputting the radius of gyration.Type: ApplicationFiled: September 9, 2021Publication date: December 30, 2021Inventors: Max HANEY, Michael P. MURPHY
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Patent number: 11150175Abstract: Methods for determining a radius of gyration of a particle in solution using a light scattering detector are provided. The method may include passing the solution through a flowpath in a sample cell, determining respective angular normalization factors for first and second angles of the detector, obtaining a first scattering intensity of the particle in solution at the first angle, obtaining a second scattering intensity of the particle in solution at the second angle, obtaining a 10° scattering intensity of the particle in solution at an angle of about 10°, determining a first particle scattering factor, determining a second particle scattering factor, plotting an angular dissymmetry plot, fitting a line to the angular dissymmetry plot, determining a slope of the line at a selected location on the line, determining the radius of gyration of the particle in solution from the slope of the line, and outputting the radius of gyration.Type: GrantFiled: January 2, 2019Date of Patent: October 19, 2021Assignee: M & J Scientific, LLCInventors: Max Haney, Michael P. Murphy
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Publication number: 20210223172Abstract: Sample cells, light scattering detectors utilizing the sample cells, and methods for using the same are provided. The sample cell may include a body defining a flowpath extending axially therethrough. The flowpath may include a cylindrical inner section interposed between a first outer section and a second outer section. The first outer section may be frustoconical. A first end portion of the first outer section may be in direct fluid communication with the inner section and may have a cross-sectional area relatively smaller than a cross-sectional area at a second end portion thereof. The body may further define an inlet in direct fluid communication with the inner section. The inlet may be configured to direct a sample to the inner section of the flowpath.Type: ApplicationFiled: January 2, 2019Publication date: July 22, 2021Inventors: Max HANEY, Michael P. MURPHY
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Publication number: 20210223160Abstract: Methods for determining a radius of gyration of a particle in solution using a light scattering detector are provided. The method may include passing the solution through a flowpath in a sample cell, determining respective angular normalization factors for first and second angles of the detector, obtaining a first scattering intensity of the particle in solution at the first angle, obtaining a second scattering intensity of the particle in solution at the second angle, obtaining a 10° scattering intensity of the particle in solution at an angle of about 10°, determining a first particle scattering factor, determining a second particle scattering factor, plotting an angular dissymmetry plot, fitting a line to the angular dissymmetry plot, determining a slope of the line at a selected location on the line, determining the radius of gyration of the particle in solution from the slope of the line, and outputting the radius of gyration.Type: ApplicationFiled: January 2, 2019Publication date: July 22, 2021Inventors: Max HANEY, Michael P. MURPHY
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Patent number: 10551291Abstract: Viscometers and Viscometry methods are disclosed. In one general aspect a capillary bridge viscometer comprises an input port an output port a first capillary tubing arm in a first hydraulic path between the input port and a first differential detection point, a second capillary tubing arm in a second hydraulic path between the first differential detection point and the output port, a third capillary tubing arm in a third hydraulic path between the input port and a second differential detection point, a fourth capillary tubing arm in a fourth hydraulic path between the second differential detection point and the output port, an adjustable mechanical flow restrictor in one of the first, second, third, and fourth hydraulic paths, wherein the adjustable mechanical flow restrictor is operative to mechanically adjust a resistance to flow of a fluid while the fluid flows through the adjustable mechanical flow restrictor.Type: GrantFiled: September 11, 2017Date of Patent: February 4, 2020Assignee: Malvern Panalytical Inc.Inventors: Michael P. Murphy, Mark Nicholls
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Publication number: 20180106710Abstract: Viscometers and Viscometry methods are disclosed. In one general aspect a capillary bridge viscometer comprises an input port an output port a first capillary tubing arm in a first hydraulic path between the input port and a first differential detection point, a second capillary tubing arm in a second hydraulic path between the first differential detection point and the output port, a third capillary tubing arm in a third hydraulic path between the input port and a second differential detection point, a fourth capillary tubing arm in a fourth hydraulic path between the second differential detection point and the output port, an adjustable mechanical flow restrictor in one of the first, second, third, and fourth hydraulic paths, wherein the adjustable mechanical flow restrictor is operative to mechanically adjust a resistance to flow of a fluid while the fluid flows through the adjustable mechanical flow restrictor.Type: ApplicationFiled: September 11, 2017Publication date: April 19, 2018Inventors: Michael P. Murphy, Mark Nicholls
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Patent number: 9759644Abstract: A capillary bridge viscometer, comprises an input port (flow in) an output port (flow out) a first capillary tubing arm (R1) in a first hydraulic path between the input port and a first differential detection point (DP+), a second capillary tubing arm (R3) in a second hydraulic path between the first differential detection point (DP+) and the output port (flow out), a third capillary tubing arm (R2) in a third hydraulic path between the input port (flow in) and a second differential detection point (DP?), a fourth capillary tubing arm (R4) in a fourth hydraulic path between the second differential detection point (DP?) and the output port (flow out), an adjustable mechanical flow restrictor (20) in one of the first, second, third, and fourth hydraulic paths, wherein the adjustable mechanical flow restrictor (20) is operative to mechanically adjust a resistance to flow of a fluid while the fluid flows through the adjustable mechanical flow restrictor.Type: GrantFiled: September 23, 2011Date of Patent: September 12, 2017Assignee: Malvern Instruments IncorporatedInventors: Mark Nicholls, Michael P. Murphy
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Publication number: 20170167634Abstract: An ER fluid valve includes a housing and a plurality of parallel flow passages through the housing each defined by spaced electrodes at least one of which is controllable independently of other flow passages electrodes. A controller is configured to selectively establish electrical fields for all of the independently controllable electrodes to close all of the flow passages to ER fluid flowing through the housing. By removing the fields from all of the independently controllable electrodes, all the flow passages are open to the ER fluid flowing through the housing. By establishing fields for select independently controllable electrodes to close their associated flow passages and by leaving other flow passages open, restricted flow of the ER fluid through the housing is accomplished to vary the flow rate through the housing.Type: ApplicationFiled: February 28, 2017Publication date: June 15, 2017Inventors: Michael P. Murphy, Robert Playter
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Patent number: 9612183Abstract: A capillary bridge viscometer (120), comprises at least two at least generally balanced bridge arm conduits (R1, R2) a bulkhead supporting structure (122,134) supporting removable connection portions for each of a plurality of the arms in a bridge configuration, a bridge supporting structure (124,136) supporting the bridge arm conduits (R1,R2) and supporting two further removable connection portions (132) for each of the bridge arm conduits, wherein each of the further removable connection portions (132) supported by the bridge supporting structure are positioned to mate with a corresponding one of the removable connection portions (130) supported by the bulkhead supporting structure concurrently to hydraulically connect the bridge arm conduits in the bridge configuration; and a balance detector having hydraulic connections for connection between first and second differential detection points in the bridge when the removable connection portions on the bridge are mated to corresponding ones of the removable coType: GrantFiled: September 23, 2011Date of Patent: April 4, 2017Assignee: Malvern Instruments IncorporatedInventors: Paul G. Clarke, Michael P. Murphy
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Publication number: 20160245413Abstract: An ER fluid valve includes a housing and a plurality of parallel flow passages through the housing each defined by spaced electrodes at least one of which is controllable independently of other flow passages electrodes. A controller is configured to selectively establish electrical fields for all of the independently controllable electrodes to close all of the flow passages to ER fluid flowing through the housing. By removing the fields from all of the independently controllable electrodes, all the flow passages are open to the ER fluid flowing through the housing. By establishing fields for select independently controllable electrodes to close their associated flow passages and by leaving other flow passages open, restricted flow of the ER fluid through the housing is accomplished to vary the flow rate through the housing.Type: ApplicationFiled: February 10, 2015Publication date: August 25, 2016Inventors: Michael P. Murphy, Robert Playter
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Patent number: 8973613Abstract: An ER fluid valve includes a housing and a plurality of parallel flow passages through the housing each defined by spaced electrodes at least one of which is controllable independently of other flow passages electrodes. A controller is configured to selectively establish electrical fields for all of the independently controllable electrodes to close all of the flow passages to ER fluid flowing through the housing. By removing the fields from all of the independently controllable electrodes, all the flow passages are open to the ER fluid flowing through the housing. By establishing fields for select independently controllable electrodes to close their associated flow passages and by leaving other flow passages open, restricted flow of the ER fluid through the housing is accomplished to vary the flow rate through the housing.Type: GrantFiled: April 27, 2011Date of Patent: March 10, 2015Assignee: Google Inc.Inventors: Michael P. Murphy, Robert Playter
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Publication number: 20140144214Abstract: A capillary bridge viscometer, comprises an input port (flow in) an output port (flow out) a first capillary tubing arm (R1) in a first hydraulic path between the input port and a first differential detection point (DP+), a second capillary tubing arm (R3) in a second hydraulic path between the first differential detection point (DP+) and the output port (flow out), a third capillary tubing arm (R2) in a third hydraulic path between the input port (flow in) and a second differential detection point (DP?), a fourth capillary tubing arm (R4) in a fourth hydraulic path between the second differential detection point (DP?) and the output port (flow out), an adjustable mechanical flow restrictor (20) in one of the first, second, third, and fourth hydraulic paths, wherein the adjustable mechanical flow restrictor (20) is operative to mechanically adjust a resistance to flow of a fluid while the fluid flows through the adjustable mechanical flow restrictor.Type: ApplicationFiled: September 23, 2011Publication date: May 29, 2014Inventors: Mark Nicholls, Michael P. Murphy
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Patent number: 8667844Abstract: Presented is a system and method for testing the adhesion of coatings to substrates using an ultrasonic scalar. The system comprises a body, a flexible scalpel extending from said body, and a source of ultrasonic waves. The flexible scalpel applies pressure and ultrasonic waves to a coating that is removed when the adhesion of the coating to the substrate is substandard. The method comprises applying an flexible scalpel extending from an ultrasonic adhesion test device to a coating, applying ultrasonic waves through the flexible scalpel to the coating while moving across the coating, removing the coating if there is less than an acceptable adhesion of the coating to the substrate, and inspecting the coating to determine if coating was removed from the substrate.Type: GrantFiled: January 28, 2011Date of Patent: March 11, 2014Assignee: The Boeing CompanyInventors: Christopher L. Broadbent, Michael P. Murphy, Randall Jahren
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Publication number: 20140060162Abstract: A capillary bridge viscometer (120), comprises at least two at least generally balanced bridge arm conduits (R1, R2) a bulkhead supporting structure (122,134) supporting removable connection portions for each of a plurality of the arms in a bridge configuration, a bridge supporting structure (124,136) supporting the bridge arm conduits (R1,R2) and supporting two further removable connection portions (132) for each of the bridge arm conduits, wherein each of the further removable connection portions (132) supported by the bridge supporting structure are positioned to mate with a corresponding one of the removable connection portions (130) supported by the bulkhead supporting structure concurrently to hydraulically connect the bridge arm conduits in the bridge configuration; and a balance detector having hydraulic connections for connection between first and second differential detection points in the bridge when the removable connection portions on the bridge are mated to corresponding ones of the removable coType: ApplicationFiled: September 23, 2011Publication date: March 6, 2014Inventors: Paul G. Clarke, Michael P. Murphy