Abstract: The ?2-adrenergic receptor (?2AR) is a primary target in the treatment of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD). Since ?-agonist treatment of airway disease can have severe side effects, compounds that attenuate the side effects of ?-agonists have been identified via their ability to inhibit ?2AR interaction with ?-arrestins. These compounds are specific for the ?2AR and effectively protect against the desensitization observed with ?-agonist treatment in model cells and airway tissue. The present disclosure provides compounds and methods for treating airway disease, such as but not limited to COPD and/or asthma.

Abstract: A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes.

Abstract: A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes.

Abstract: A bottle capping chuck that uses serrated segments with a cap torque ramp angle to grip and torque a bottle cap combined with other segments that utilize holding segments both combining to eliminate slippage and stripping and holding of bottle caps during a bottle capping process.

Abstract: The capping industry has many variations in each cap that is placed on containers. It is very critical that a capping chuck have the ability to adapt quickly and easily to each and every cap that is available. The present invention uses the flexibility in its construction to grasp all variations to the caps without the need for expensive and time consuming shut downs. The present capping chuck meets these ever expanding changes within the industry.

Abstract: A bottle capping chuck that uses serrated segments with a cap torque ramp angle to grip and torque a bottle cap combined with other segments that utilize holding segments both combining to eliminate slippage and stripping and holding of bottle caps during a bottle capping process.

Abstract: A tool-less adjustable torque setting assembly for a bottle capping headset wherein there is a witness mark and a push button. The operator pushes in the button and a tooth on the button's inside surface of the housing disengages with the inside wall of the housing where there are a series of mating teeth. The assembly is rotated to the desired setting and released. The button, which is spring loaded, will return to the seated position in the series of teeth within the housing. No tools are required to adjust the torque setting.

Abstract: A tool-less adjustable torque setting assembly for a bottle capping headset wherein there is a witness mark and a push button. The operator pushes in the button and a tooth on the button's inside surface of the housing disengages with the inside wall of the housing where there are a series of mating teeth. The assembly is rotated to the desired setting and released. The button, which is spring loaded, will return to the seated position in the series of teeth within the housing. No tools are required to adjust the torque setting.

Abstract: The capping industry has many variations in each cap that is placed on containers. It is very critical that a capping chuck have the ability to adapt quickly and easily to each and every cap that is available. The present invention uses the flexibility in its construction to grasp all variations to the caps without the need for expensive and time consuming shut downs. The present capping chuck meets these ever expanding changes within the industry.

Abstract: Capping head assemblies that are useful for applying pre-threaded closures onto containers with improved sensitivity. The novel features of the devices are a simple and novel means of adjusting the torque in a magnetic clutch assembly. In addition, the advantage of preventing contamination by water and other liquids during the filling and capping of liquid containers, and further, have the capability of being greased without having to disassemble the device. In addition, these can be accomplished without changing the capability of being able to read the adjustment scales on the outside surface of the magnetic clutch assembly and the adjustment scales on the outside surface of the upper spring assembly for adjusting the tension in the spring.

Abstract: A clutch/brake mechanism designed for use in a power driven system which delivers relatively high braking and driving power while avoiding simultaneous engagement of the clutch and the brake includes a device for actuating the clutch and the brake such that the clutch is effectively engaged by relatively slight actuation of the actuator device and the brake is effectively engaged by relatively considerable actuation of the actuator device.